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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	557-05-1
Chemical Name	Zinc stearate
Substance ID	H26-B-061, R-025
Classification year (FY)	FY2014
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	- -	-	-	No data available.
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 420 deg C (HSDB (Access on August 2014)).
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	From the result that it is insoluble in water (ICSC (2000)), it is estimated that it does not react vigorously with water.
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine), and because the oxygen is an oxygen ion ionically bonded to zinc, it does not contribute to oxidization.
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	It was classified as "Not classified" based on a report of > 5,000 mg/kg as an LD50 value for rats (EU-RAR (2009)).
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" based on a report of > 2,000 mg/kg as an LD50 value for rabbits (EU-RAR (2009)). The new information source (EU-RAR (2009)) was added, and the category was revised.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	It was classified as "Not classified" based on reports of > 200,000 mg/m3 (converted 4-hour equivalent value: > 50 mg/L) as an LC50 value (1 hour) for rats (EU-RAR (2009), ACGIH (7th, 2001)). Besides, since the LC50 value was higher than the saturated vapor concentration (9.2*10−14 mg/L), the reference value of the mist was applied.
2	Skin corrosion/irritation	Not classified	- -	-	-	There are reports that in two skin irritation tests with rabbits, no irritation was observed (EU-RAR (2009), IUCLID (2000)) and that no irritation was observed in a test (4-hour application) with rats (EU-RAR (2009)). There is a report that in humans, no irritation was observed in a patch test (EU-RAR (2009)). It was classified as "Not classified" since there are no reports of irritation in humans and animals. The data in the previous classification were deleted due to being not specific data, and the category was revised.
3	Serious eye damage/eye irritation	Not classified	- -	-	-	Since there are two reports that no irritation was observed as a result of application of undiluted liquid of this substance to rabbits (EU-RAR (2009), IUCLID (2000)), it was classified as "Not classified." Since information sources were added, and the data in the previous classification were deleted due to being not specific data, and the category was revised.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification was not possible due to lack of data. Besides, there are descriptions that as a result of applying the substance containing 10% of this substance to 202 volunteers, no sensitization was observed (EU-RAR (2009)), and that there is no skin sensitization in humans (IUCLID (2000)).
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" since it was classified in A4 by ACGIH (ACGIH (7th, 2001)).
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification was not possible due to lack of data. Besides, as for the description that "the possibility of respiratory tract irritation in humans was described" (ACGIH (7th, 2001), EU-RAR (2004)) in the previous classification, as a result of confirmation, the possibility of respiratory tract irritation in humans as stearates in general was described in ACGIH (7th, 2001). However, as for this substance, it is described in EU-RAR (2009) that "it is not corrosive nor irritating," and the finding of the previous classification was not adopted.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	There are no findings of hazards associated with repeated exposure to this substance in either humans or experimental animals. Therefore, classification was not possible due to lack of data. Besides, there is a description that humans who ingested zinc as zinc sulfate or zinc gluconate developed headaches, nausea, and gastrointestinal symptoms such as stomach discomfort as well as laboratory abnormalities indicating copper deficiency (decreased serum ceruloplasmin and SOD activity of erythrocytes (EU-RAR (2009))).
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Not classified	- -	-	-	From 48h EC50 > 100 mg/L for crustacea (Daphnia magna) and the fact that the effects were not found at the concetrations that are equal to or 3-4 orders of magnitude higher than water solubility in acute toxicity tests for fish (Danio rerio, Lepomis macrochirus) (EU-RAR, 2008), it was classified as "Not classified."
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	Reliable chronic toxicity data were not obtained. It was classified as "Not classified" in acute toxicity, and is water-insoluble (water solubility = 0.97 mg/L, EU-RAR, 2008) and not rapidly degradable (a degradation rate in a 28-day degradation test according to OECD TG 301D: 5% (EU-RAR, 2008)), but due to a low bioconcentration estimate (log Kow = 1.2 (EU-RAR, 2008)), it was classified as "Not classified."
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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