GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 7783-00-8
Chemical Name Selenious acid
Substance ID H26-B-057, -
Classification year (FY) FY2014
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive properties.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Solid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Solid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Solid (GHS definition)
6 Flammable liquids Not applicable
-
-
- - Solid (GHS definition)
7 Flammable solids Not classified
-
-
- - It is not combustible (ICSC (2000)).
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- - Solid (GHS definition)
10 Pyrophoric solids Not classified
-
-
- - It is not combustible (ICSC (2000)).
11 Self-heating substances and mixtures Not classified
-
-
- - It is not combustible (ICSC (2000)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- - Because data of water solubility of 167 g/100 mL (20 deg C) (ICSC (2000)) were obtained, it is estimated that it does not react vigorously with water.
13 Oxidizing liquids Not applicable
-
-
- - Solid (GHS definition)
14 Oxidizing solids Classification not possible
-
-
- - It is an inorganic compound containing oxygen (but not halogen), but the classification is not possible due to no data.
15 Organic peroxides Not applicable
-
-
- - It is an inorganic compound.
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, there are reports of 4.8-7.0 mg/kg (ATSDR (2003), ACGIH (7th, 2001), OEL Documentations (Japan Society For Occupational Health (JSOH, 2000)), EHC 85 (1986)) as LD50 values of selenium content in selenite for rats. When these values are converted to values of this substance, they are 7.7-11.3 mg/kg, which corresponds to Category 2.
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
There is a description that this substance caused chemical burns (EHC 58 (1986), HSDB (Access on July 2014)) and since it is considered to show skin corrosivity, it was classified in Category 1.
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
There is no information on the effects on the eyes of this substance. However, since based on a description that this substance caused chemical burns (HSDB (Access on July 2014)), it was classified as Category 1 in the classification of skin corrosion/irritation, it was also classified in Category 1 for this hazard class.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
6 Carcinogenicity Classification not possible
-
-
- - Since it was classified in Group 3 by IARC (suppl 7, 1987) and as D by EPA (2005), it was classified as "Classification not possible."
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data.
Besides, as information in List 3, there is a report that no malformations developed below the doses where toxicity was manifested in parental animals in teratogenicity tests with rats, mice, rabbits, hamsters, and cynomolgus monkeys (Chemical Substance Hazard Data (CERI) 2001-39 (2), 2002). However, there are no data from List 1 and List 2 and no information on reproductive toxicity, therefore, it was classified as "Classification not possible."
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, respiratory organs, cardiovascular system, liver, kidney)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
This substance was corrosive and irritating to the respiratory tract (ATSDR (2003), HSDB (Access on August 2014)). In humans, bronchospasm, cough, nausea, vomiting, syncope, tachycardia, tachypnea, slight hypotension, chills, diarrhea, headache, fever, cyanosis, dyspnea, leukocytosis and chemical pneumonitis were observed after inhalation exposure to the fume of this substance (HSDB (Access on August 2014)). Besides, by oral exposure, there is a report of salivation, garlic odor of breath, vomiting, diarrhea, severe gastrointestinal disorders, convulsions, shallow breath, elevated blood pressure, increased heart rate, adult respiratory distress syndrome, respiratory insufficiency, severe myopathy, metabolic acidosis, leukocytosis, hyperglycemia, cardiomyopathy, cardiac arrhythmia, moderate liver, kidney and lung dysfunction, neuropathy, respiratory insufficiency syndrome, myocardial infarction, renal failure and deaths by accidental ingestion, etc. of Gun Blue (gun blue: treatment agent of oxide film containing selenious acid, nitric acid and copper nitrate) containing this substance (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (2003), HSDB (Access on August 2014), PATTY (6th, 2012)).
From the above, since effects on the central nervous system, respiratory organs and cardiovascular system were observed by inhalation exposure of humans, and by oral exposure of humans, the central nervous system, respiratory organs, cardiovascular system, liver and kidney were considered to be the target organs in multiple cases due to ingestion of Gun Blue and other cases, it was classified in Category 1 (central nervous system, respiratory organs, cardiovascular system, liver, kidney).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, respiratory organs, haemal system, liver, kidney, testis)


Danger
H372 P260
P264
P270
P314
P501
There were no adverse findings by repeated exposures to this substance in either humans or experimental animals. However, dogs or rats were exposed by inhalation to this substance and metallic selenium, and absorption rate and distribution, etc. were compared between them. As a result, based on findings of in vivo kinetics that this substance showed better absorption than metallic selenium, and the distribution and metabolic processes after absorption were almost the same (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (2003), EHC (1986)), it was considered that the toxicity of this substance is almost equivalent to that of metallic selenium. Therefore, based on metal selenium (CAS RN 7782-49-2), it was classified in Category 1 (nervous system, respiratory organs, liver).
On the other hand, there are multiple studies in which the sodium salt of this substance (sodium selenite; CAS RN 10102-18-8) was orally administered to experimental animals and toxicities were considered equivalent to those by repeated oral exposures of this substance, so these were also used for GHS classification.
In multiple studies where sodium selenite was administered by feeding to rats for 4-13 weeks, at doses corresponding to Category 1 (converted guidance value as sodium selenite: 0.0044-1.88 mg/kg/day), effects on the liver (centrilobular diffuse nodules, sinusoidal dilation, hepatocellular necrosis and portal infiltration of mononuclear cells, etc.), kidney (denaturation of renal papilla, necrosis), hemal system (decreased hemoglobin concentration, spleen enlargement), and testis (decreased weight, morphological abnormality of sperm, decreased sperm counts in the epididymis) were observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (2003)). In addition, it is reported that in a study with guinea pigs administered by feeding for 60 days, at a dose within the range of Category 1 (15 ppm=0.75 mg Se/kg/day; converted to 90-day exposure of sodium selenite: 1.09 mg/kg/day), blood toxicity (anaemia, decreased lymphocytes) were observed, and that, also in a test with rats administered by feeding for 2 years, effects on the liver (degeneration of liver parenchyma, hyperplasia) and the kidney (nephritis) were observed at a dose (0.1 mg/kg/day) corresponding to Category 1 (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (2003)).
From the above, in consideration of the classification results of metal selenium subject to this by the inhalation route and sodium selenite by the oral route, it was classified in Category 1 (nervous system, respiratory organs, hemal system, liver, kidney, testis).
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) -
-
-
- - -
11 Hazardous to the aquatic environment (Long-term) -
-
-
- - -
12 Hazardous to the ozone layer -
-
-
- - -


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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