Item | Information |
---|---|
CAS RN | 7446-08-4 |
Chemical Name | Selenium dioxide |
Substance ID | H26-B-055, - |
Classification year (FY) | FY2014 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive properties. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
7 | Flammable solids | Not classified |
- |
- | - | It is not combustible (ICSC (2000)). |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is not combustible (ICSC (2000)). |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (ICSC (2000)). |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | Because data of water solubility of 40 g/100 mL (20 deg C) (ICSC (2000)) were obtained, it is estimated that it does not react vigorously with water. |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an inorganic compound containing oxygen (but not halogen), but the classification is not possible due to no data. |
15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic compound. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 |
P301+P310
P361+P364 P264 P270 P321 P330 P405 P501 |
Based on a report of an LD50 value for rats of 48 mg Se/kg (a converted value equivalent to SeO2: 67.5 mg/kg) (ATSDR (2003)), it was classified in Category 3. The LD50 value as selenium was converted to a value equivalent to this substance, and the category was revised. |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | There is a description that this substance was irritating in contact with the skin (HSDB (Access on July 2014)). In addition, there is a report that skin irritation was observed by occupational exposure (EHC 58 (1986)). On the other hand, there is a description that this substance (powder form) did not damage the skin, but selenious acid produced by reaction with this substance and water or sweat was irritating (EHC 58 (1986)). However, it was determined that metabolite information wan not used for classification. From the above, it was classified as "Classification not possible." |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 |
P305+P351+P338
P337+P313 P264 P280 |
There is a report of eye irritation by this substance in occupational exposure (EHC 58 (1986), PATTY (6th, 2012)). From the above result, it was classified in Category 2. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there is a report that allergic rash was observed in occupational exposure to this substance (EHC 58 (1986)), but these data were judged to be insufficient for use in the classification since the details are unknown. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There are no in vivo data. As for in vitro, it was positive in a bacterial reverse mutation test and a chromosomal aberration test with human leukocytes (ATSDR (2003), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Since selenium and its compounds were classified in Group 3 by IARC (suppl 7, 1987) and in D by EPA (1991), it was classified as "Classification not possible." |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system, respiratory organs, heart, haemal system, kidney) |
Danger |
H370 |
P308+P311
P260 P264 P270 P321 P405 P501 |
This substance is irritating (ATSDR (2003)). In humans, there are reports of chills, fever, headache, burning sensation of the nose, dizziness, dyspnea, bronchial spasms, asphyxiation, persistent bronchitis, pneumonia, shock symptoms including hypotension and elevated pulse rate, acute pulmonary edema, mucosal damage in the oral cavity, esophagus and stomach, nausea, vomiting, stomach pain and hematemesis by inhalation exposure. In oral ingestion, there are reports of hematemesis, hypotension, toxic cardiomyopathy, pulmonary edema, seizures and coma. In the case of suicides by ingestion, congestion of the lung and kidney, diffuse swelling of the heart and cerebral edema were observed at necropsy. The most characteristic finding of those suicide cases was an orange-brown discoloration of the skin and whole viscera, which is considered to be due to the hemolysis and pigmentation related to this substance (ATSDR (2003), PATTY (6th, 2012), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), HSDB (Access on August 2014)). Besides, ataxia, dyspnea and other neurological symptoms as acute effects of selenium, in addition, severe gastrointestinal disorder, neuropathy, respiratory insufficiency syndrome, myocardial infarction and renal failure by ingestion of selenium at the gram scale are reported (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (2003)). In experimental animals tests, there is a description that the primary injury sites by acute inhalation exposure to elemental selenium and selenium compounds were the respiratory organs (ATSDR (2003)). From the above, this substance is considered to affect the central nervous system, respiratory organs, heart, hemal system and kidney in humans, and it was classified in Category 1 (central nervous system, respiratory organs, heart, hemal system, kidney). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system, respiratory organs), Category 2 (liver) |
Danger Warning |
H372
H373 |
P260
P264 P270 P314 P501 |
On inhalation of selenium dioxide, over half of 62 occupationally exposed workers complained of sleeplessness, loss of appetite or nausea, 26 workers complained of headaches and 3 workers complained of cramp-like pains. Mucosal irritation, conjunctivitis and bronchitis were observed in 9 workers according to the diagnosis (EHC 58 (1986), ATSDR (2003), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). In addition, there is a report that rhinitis, nasal bleeding, headaches, loss of weight, irritability and pain in the extremities were observed in workers exposed to a aerosol mix of metallic selenium and this substance for prolonged periods (EHC 58 (1986)). On the other hand, there is no toxicity information by repeated administration of this substance to experimental animals. From the above, based on findings observed in occupational exposures by inhalation in humans, the target organs are considered to be the nervous system, respiratory organs and gastrointestinal tract. However, it was also considered that gastrointestinal symptoms may be indefinite complaints due to irritation of the respiratory organs, etc., and it was considered there is limited objective evidence to determine a specific target organ by exposure to this substance. In addition, it is described in the report on the occupational exposure to selenium dioxide in the opening paragraph that liver dysfunctions were observed in some cases without correlation with blood selenium levels (EHC 58 (1986)). There are no test results for exposure of experimental animals to this substance, and there is little evidence to adopt the "liver" as the target organ. However, it is assumed that this substance also may act like other selenium compounds after taken into the body, so the "liver" was also added to the target organ (category was determined to be "2" because of lack of evidence data in experimental animals) in consideration of consistency with the classification results for other selenium compounds. Therefore, it was classified in Category 1 (nervous system, respiratory organs), Category 2 (liver). Besides, in the previous classification, the "kidney" was adopted as the target organ according to an information source which is not listed in the GHS classification guidance for the Japanese government, but in the data collected for the classification of multiple selenium compounds subject to this survey, there is no information in List 1available. Therefore, it was judged that there is no reason to regard the kidney as a common target organ, therefore, the "kidney" was deleted from the target organ. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment (Long-term) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
|