GHS Classification Result

日本語で表示



GENERAL INFORMATION
Item Information
CAS RN 7446-08-4
Chemical Name Selenium dioxide
Substance ID H26-B-055, -
Classification year (FY) FY2014
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive properties.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Solid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Solid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Solid (GHS definition)
6 Flammable liquids Not applicable
-
-
- - Solid (GHS definition)
7 Flammable solids Not classified
-
-
- - It is not combustible (ICSC (2000)).
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- - Solid (GHS definition)
10 Pyrophoric solids Not classified
-
-
- - It is not combustible (ICSC (2000)).
11 Self-heating substances and mixtures Not classified
-
-
- - It is not combustible (ICSC (2000)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- - Because data of water solubility of 40 g/100 mL (20 deg C) (ICSC (2000)) were obtained, it is estimated that it does not react vigorously with water.
13 Oxidizing liquids Not applicable
-
-
- - Solid (GHS definition)
14 Oxidizing solids Classification not possible
-
-
- - It is an inorganic compound containing oxygen (but not halogen), but the classification is not possible due to no data.
15 Organic peroxides Not applicable
-
-
- - It is an inorganic compound.
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 3


Danger
H301 P301+P310
P361+P364
P264
P270
P321
P330
P405
P501
Based on a report of an LD50 value for rats of 48 mg Se/kg (a converted value equivalent to SeO2: 67.5 mg/kg) (ATSDR (2003)), it was classified in Category 3. The LD50 value as selenium was converted to a value equivalent to this substance, and the category was revised.
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- - There is a description that this substance was irritating in contact with the skin (HSDB (Access on July 2014)). In addition, there is a report that skin irritation was observed by occupational exposure (EHC 58 (1986)). On the other hand, there is a description that this substance (powder form) did not damage the skin, but selenious acid produced by reaction with this substance and water or sweat was irritating (EHC 58 (1986)). However, it was determined that metabolite information wan not used for classification. From the above, it was classified as "Classification not possible."
3 Serious eye damage/eye irritation Category 2


Warning
H319 P305+P351+P338
P337+P313
P264
P280
There is a report of eye irritation by this substance in occupational exposure (EHC 58 (1986), PATTY (6th, 2012)). From the above result, it was classified in Category 2.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, there is a report that allergic rash was observed in occupational exposure to this substance (EHC 58 (1986)), but these data were judged to be insufficient for use in the classification since the details are unknown.
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data. There are no in vivo data. As for in vitro, it was positive in a bacterial reverse mutation test and a chromosomal aberration test with human leukocytes (ATSDR (2003), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)).
6 Carcinogenicity Classification not possible
-
-
- - Since selenium and its compounds were classified in Group 3 by IARC (suppl 7, 1987) and in D by EPA (1991), it was classified as "Classification not possible."
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, respiratory organs, heart, haemal system, kidney)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
This substance is irritating (ATSDR (2003)). In humans, there are reports of chills, fever, headache, burning sensation of the nose, dizziness, dyspnea, bronchial spasms, asphyxiation, persistent bronchitis, pneumonia, shock symptoms including hypotension and elevated pulse rate, acute pulmonary edema, mucosal damage in the oral cavity, esophagus and stomach, nausea, vomiting, stomach pain and hematemesis by inhalation exposure. In oral ingestion, there are reports of hematemesis, hypotension, toxic cardiomyopathy, pulmonary edema, seizures and coma. In the case of suicides by ingestion, congestion of the lung and kidney, diffuse swelling of the heart and cerebral edema were observed at necropsy. The most characteristic finding of those suicide cases was an orange-brown discoloration of the skin and whole viscera, which is considered to be due to the hemolysis and pigmentation related to this substance (ATSDR (2003), PATTY (6th, 2012), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), HSDB (Access on August 2014)).
Besides, ataxia, dyspnea and other neurological symptoms as acute effects of selenium, in addition, severe gastrointestinal disorder, neuropathy, respiratory insufficiency syndrome, myocardial infarction and renal failure by ingestion of selenium at the gram scale are reported (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (2003)). In experimental animals tests, there is a description that the primary injury sites by acute inhalation exposure to elemental selenium and selenium compounds were the respiratory organs (ATSDR (2003)).
From the above, this substance is considered to affect the central nervous system, respiratory organs, heart, hemal system and kidney in humans, and it was classified in Category 1 (central nervous system, respiratory organs, heart, hemal system, kidney).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, respiratory organs), Category 2 (liver)


Danger
Warning
H372
H373
P260
P264
P270
P314
P501
On inhalation of selenium dioxide, over half of 62 occupationally exposed workers complained of sleeplessness, loss of appetite or nausea, 26 workers complained of headaches and 3 workers complained of cramp-like pains. Mucosal irritation, conjunctivitis and bronchitis were observed in 9 workers according to the diagnosis (EHC 58 (1986), ATSDR (2003), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). In addition, there is a report that rhinitis, nasal bleeding, headaches, loss of weight, irritability and pain in the extremities were observed in workers exposed to a aerosol mix of metallic selenium and this substance for prolonged periods (EHC 58 (1986)).
On the other hand, there is no toxicity information by repeated administration of this substance to experimental animals.
From the above, based on findings observed in occupational exposures by inhalation in humans, the target organs are considered to be the nervous system, respiratory organs and gastrointestinal tract. However, it was also considered that gastrointestinal symptoms may be indefinite complaints due to irritation of the respiratory organs, etc., and it was considered there is limited objective evidence to determine a specific target organ by exposure to this substance. In addition, it is described in the report on the occupational exposure to selenium dioxide in the opening paragraph that liver dysfunctions were observed in some cases without correlation with blood selenium levels (EHC 58 (1986)). There are no test results for exposure of experimental animals to this substance, and there is little evidence to adopt the "liver" as the target organ. However, it is assumed that this substance also may act like other selenium compounds after taken into the body, so the "liver" was also added to the target organ (category was determined to be "2" because of lack of evidence data in experimental animals) in consideration of consistency with the classification results for other selenium compounds. Therefore, it was classified in Category 1 (nervous system, respiratory organs), Category 2 (liver). Besides, in the previous classification, the "kidney" was adopted as the target organ according to an information source which is not listed in the GHS classification guidance for the Japanese government, but in the data collected for the classification of multiple selenium compounds subject to this survey, there is no information in List 1available. Therefore, it was judged that there is no reason to regard the kidney as a common target organ, therefore, the "kidney" was deleted from the target organ.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) -
-
-
- - -
11 Hazardous to the aquatic environment (Long-term) -
-
-
- - -
12 Hazardous to the ozone layer -
-
-
- - -


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

To GHS Information