Item | Information |
---|---|
CAS RN | 600-25-9 |
Chemical Name | 1-Chloro-1-nitropropane |
Substance ID | H26-B-040, - |
Classification year (FY) | FY2014 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Classification not possible |
- |
- | - | Because there is a chemical group associated with explosive properties (nitro group) present in the molecule, and oxygen balance of -84.2 is higher than the criteria of -200, it may correspond to explosives. However, the classification is not possible due to no data. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 4 |
Warning |
H227 |
P370+P378
P403+P235 P210 P280 P501 |
It was classified in Category 4 based on a flash point of 62 deg C (closed cup) (GESTIS (Access on July 2014)). |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | There is a chemical group associated with explosive properties (nitro group) present in the molecule, but the classification is not possible due to no data. |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data available. |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Classification not possible |
- |
- | - | The substance is an organic compound containing chlorine and oxygen (but not fluorine), and the oxygen is chemically bonded to the element other than carbon or hydrogen (N). However, the classification is not possible due to no data. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 |
P301+P312
P362+P364 P264 P270 P330 P501 |
Based on an LD50 value of 510 mg/kg for mice (DFGOT vol. 11 (1998)), it was classified in Category 4. |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | Based on an LC50 value (3 hours) of 66,000 mg/m3 (= 66 mg/L) for mice (converted 4-hour equivalent value: 49.5 mg/L) (DFGOT vol.1 (1991)), it was classified as "Not classified." Besides, the reference value of a mist was applied because the LC50 value was higher than the saturated vapor concentration (39 mg/L). |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, although there are reports that this substance did not show clear irritation to the skin (HSDB (Access on July 2014)) and that application of 5 mL of the undiluted liquid of this substance for 10 days (2 times/day) resulted in a slight erythema (DFGOT vol. 1 (1991)), these data were not used for classification because details of the test conditions were unknown and the data were based on a repeated dose study. Furthermore, information used in the previous classification was based on effects on the skin in a repeated dose study, and therefore, the data was not used for the classification. |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 |
P305+P351+P338
P337+P313 P264 P280 |
Based on a description that the vapour of this substance irritated the eyes (DFGOT vol. 11 (1998), HSDB (Access on June 2014)), it was classified in Category 2. Because details of a description of "strong irritant" reported in HSDB was unknown and it was not possible to consider it as effects on the eyes, the data were not used for classification. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There are no in vivo data and as for in vitro, it was positive in bacterial reverse mutation tests (DFGOT vol. 11 (1998)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
There is no reliable information on humans. In experimental animals, there are descriptions of respiratory tract irritation and narcotic effects on mice. Lacrimation and irritation of the nasal and bronchial mucosa were observed in rabbits and guinea pigs (ACGIH (7th, 2001), DFGOT vol. 11 (1998), HSDB (Access on June 2014), PATTY (6th, 2012)). Besides, a description of narcotic effects was not used for classification because it was described only in one information source (DFGOT vol. 11 (1998)). From the above, it was classified in Category 3 (respiratory tract irritation). |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment (Long-term) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
|