GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 600-25-9
Chemical Name 1-Chloro-1-nitropropane
Substance ID H26-B-040, -
Classification year (FY) FY2014
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Classification not possible
-
-
- - Because there is a chemical group associated with explosive properties (nitro group) present in the molecule, and oxygen balance of -84.2 is higher than the criteria of -200, it may correspond to explosives. However, the classification is not possible due to no data.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Category 4
-
Warning
H227 P370+P378
P403+P235
P210
P280
P501
It was classified in Category 4 based on a flash point of 62 deg C (closed cup) (GESTIS (Access on July 2014)).
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible
-
-
- - There is a chemical group associated with explosive properties (nitro group) present in the molecule, but the classification is not possible due to no data.
9 Pyrophoric liquids Classification not possible
-
-
- - No data available.
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Classification not possible
-
-
- - The substance is an organic compound containing chlorine and oxygen (but not fluorine), and the oxygen is chemically bonded to the element other than carbon or hydrogen (N). However, the classification is not possible due to no data.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P362+P364
P264
P270
P330
P501
Based on an LD50 value of 510 mg/kg for mice (DFGOT vol. 11 (1998)), it was classified in Category 4.
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Not classified
-
-
- - Based on an LC50 value (3 hours) of 66,000 mg/m3 (= 66 mg/L) for mice (converted 4-hour equivalent value: 49.5 mg/L) (DFGOT vol.1 (1991)), it was classified as "Not classified." Besides, the reference value of a mist was applied because the LC50 value was higher than the saturated vapor concentration (39 mg/L).
2 Skin corrosion/irritation Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, although there are reports that this substance did not show clear irritation to the skin (HSDB (Access on July 2014)) and that application of 5 mL of the undiluted liquid of this substance for 10 days (2 times/day) resulted in a slight erythema (DFGOT vol. 1 (1991)), these data were not used for classification because details of the test conditions were unknown and the data were based on a repeated dose study. Furthermore, information used in the previous classification was based on effects on the skin in a repeated dose study, and therefore, the data was not used for the classification.
3 Serious eye damage/eye irritation Category 2


Warning
H319 P305+P351+P338
P337+P313
P264
P280
Based on a description that the vapour of this substance irritated the eyes (DFGOT vol. 11 (1998), HSDB (Access on June 2014)), it was classified in Category 2. Because details of a description of "strong irritant" reported in HSDB was unknown and it was not possible to consider it as effects on the eyes, the data were not used for classification.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data. There are no in vivo data and as for in vitro, it was positive in bacterial reverse mutation tests (DFGOT vol. 11 (1998)).
6 Carcinogenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation)


Warning
H335 P304+P340
P403+P233
P261
P271
P312
P405
P501
There is no reliable information on humans.
In experimental animals, there are descriptions of respiratory tract irritation and narcotic effects on mice. Lacrimation and irritation of the nasal and bronchial mucosa were observed in rabbits and guinea pigs (ACGIH (7th, 2001), DFGOT vol. 11 (1998), HSDB (Access on June 2014), PATTY (6th, 2012)). Besides, a description of narcotic effects was not used for classification because it was described only in one information source (DFGOT vol. 11 (1998)).
From the above, it was classified in Category 3 (respiratory tract irritation).

9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - Classification not possible due to lack of data.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) -
-
-
- - -
11 Hazardous to the aquatic environment (Long-term) -
-
-
- - -
12 Hazardous to the ozone layer -
-
-
- - -


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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