Item | Information |
---|---|
CAS RN | 111-65-9 |
Chemical Name | n-Octane |
Substance ID | H26-B-025, R-009 |
Classification year (FY) | FY2014 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 2 |
Danger |
H225 |
P303+P361+P353
P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
It was classified in Category 2 based on a flash point of 13 deg C (closed cup) and a boiling point of 126 deg C (ICSC (1997)). Besides, it is classified in Class 3, PG II (UN1262) in UNRTDG. |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 220 deg C (ICSC (1997)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | Based on an LC50 value (4 hours) of 118 mg/L for rats (PATTY (6th, 2012)), this substance was classified as "Not classified." Besides, since the LC50 value was higher than the saturated vapour pressure concentration (61.3 mg/L), the reference value for a mist was applied. |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 |
P302+P352
P332+P313 P362+P364 P264 P280 P321 |
There is a report that in a test with volunteers, in which this substance was applied on the forearm for 1 hour and on the thigh for 5 hours, hyperemia, inflammation and pigmentation occurred with a burning and itching sensation at the site of application (PATTY (6th, 2012)). It is also described that after the 5-hour application, blister formation was observed but this disappeared (HSDB (Access on July 2014)). Based on the above, this substance was classified in Category 2. |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 |
P305+P351+P338
P337+P313 P264 P280 |
Although no report on the eye irritation was available, it was classified in Category 2 for the skin irritation. Besides, this substance is a hydrocarbon and it was described that mild to moderate eye irritation and reversible ocular injury may occur (HSDB (Access on July 2014)), therefore, this substance was classified in Category 2. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 3 (respiratory tract irritation, narcotic effects) |
Warning |
H335
H336 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
This substance is irritating to the nose and throat (ACGIH (7th, 2001), PATTY (6th, 2012), HSDB (Access on June 2014)). In addition, there are descriptions of narcotic effects (ACGIH (2001), PATTY (6th, 2012)) and convulsions (HSDB (Access on June 2014)) when exposed to high concentrations. There are reports of cardiac arrest, respiratory paralysis, convulsions, asphyxiation and death in rats exposed to 0.2 mL (no detailed description) of this substance by inhalation, lateral position at 31 mg/L and loss of reflex at 44 mg/L in inhalation exposure of mice, narcotic effects at 6,600–13,700 ppm in inhalation exposure of mice, and respiratory arrest at 16,000 ppm and 32,000 ppm in inhalation exposure of mice (OEL Documentations (Japan Society For Occupational Health (JSOH), 1989), PATTY (6th, 2012), ACGIH (7th, 2001), HSDB (Access on June 2014)). From the above, it is considered that this substance causes respiratory tract irritation and narcotic effects, and it was classified in Category 3 (respiratory tract irritation, narcotic effects). |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
10 | Aspiration hazard | Category 1 |
Danger |
H304 |
P301+P310
P331 P405 P501 |
Since this substance is a hydrocarbon with 0.7373 of kinematic viscosity (calculated using the viscosity and the density (at 25 deg C, respectively)) described in HSDB (Access on June 2014) and there was a description that chemical pneumonitis was caused due to aspiration, which is common in hydrocarbons, in humans (HSDB (Access on June 2014)), it was classified in Category 1. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 |
Warning |
H400 |
P273
P391 P501 |
It was classified in Category 1 from 96-hour LC50 = 0.1 mg/L for crustacea (Mysidopsis bahia) (SIDS, 2010). |
11 | Hazardous to the aquatic environment (Long-term) | Category 2 |
- |
H411 |
P273
P391 P501 |
It was classified in Category 2 due to rapid degradability (it is rapidly degradable from the test results in which 70% degradation was measured after 10 days with unacclimated sewage sludge and so on (SIDS, 2010)), and NOEC = 0.028 mg/L for fish (Oryzias latipes) in an early life stage test (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1998)). |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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