Item | Information |
---|---|
CAS RN | 944-22-9 |
Chemical Name | O-Ethyl S-phenyl ethylphosphonothiolothionate (fonofos) |
Substance ID | H26-B-014, - |
Classification year (FY) | FY2014 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | From an initial melting point lower than 20 deg C, it is a liquid (GHS definition). |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Not classified |
- |
- | - | It was classified as "Not classified" from a flash point of 94 deg C (closed cup) above 93 deg C (ICSC (1997)). |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties (P-O of phosphoric acid is not self-reactive). |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data available. |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | From the information of water solubility: insoluble (ICSC (1997)), it is confirmed that it does not react vigorously with water. |
13 | Oxidizing liquids | Classification not possible |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the element other than carbon or hydrogen (P). However, the classification is not possible due to no data. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. Besides, it is described that is is corrosive to mild steel (HSDB (Access on Aug 2014)). |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 2 |
Danger |
H300 |
P301+P310
P361+P364 P264 P270 P321 P330 P405 P501 |
There are three reports of LD50 values for rats, 8 mg/kg (IPCS, PIM (G001) (1998)), 3.8-8.0 mg/kg (female), 6.8-18.5 mg/kg (male) (ACGIH (7th, 2006)). According to the revised GHS classification guidance for the Japanese government, it was classified in Category 2 to which the largest number of data corresponds. Besides, since there is no description of this substance in PATTY (6th, 2012), a revised version of PATTY (5th, 2001) which was the basis of the previous classification, the data was deleted, and the category was revised. |
1 | Acute toxicity (Dermal) | Category 1 |
Danger |
H310 |
P302+P352
P262 P264 P270 P280 P310 P321 P361 P364 P405 P501 |
There are two reports of LD50 values for rats of 147 mg/kg (ACGIH (7th, 2006)) and for rabbits of 25 mg/kg (ACGIH (7th, 2006)). Since the numbers corresponding to Category 1 and Category 2 are the same, it was classified in Category 1 with the minimum LD50 value. The data of new information sources (ACGIH (7th, 2006)) were added and the category was revised. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition). Since inhalation in gaseous form cannot be assumed, it was classified as "Not classified" |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 2 |
Danger |
H330 |
P304+P340
P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Based on LC50 (4 hours) of 0.460 mg/L and LC50 (1 hour) of 0.900 mg/L (converted 4-hour equivalent value: 0.225 mg/L) for rats (ACGIH (7th, 2006)), it was classified in Category 2. Besides, since the exposure concentration is higher than the saturated vapor pressure concentration (0.005 mg/L), the reference value for the mist was applied. |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | Based on the description that this substance did not show skin irritation to rabbits (ACGIH (2006)), it was classified as "Not classified." |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, it is described that in a test with rabbits, eye irritation was observed but was negligible (ACGIH (2006)). |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a mouse bone marrow micronucleus test (HSDB (Access on June 2014)). As for in vitro, there are both negative and positive results in bacterial reverse mutation tests and a chromosomal aberration test with cultured mammalian cells (ACGIH (7th, 2006), HSDB (Access on June 2014)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Since it was classified in A4 in ACGIH (ACGIH (7th, 2006)) and in Group E in EPA (EPA Pesticide (1999)), the classification of ACGIH was prioritized and it was classified as "Classification not possible." |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 |
P308+P313
P201 P202 P280 P405 P501 |
There is a report that there was no abnormality in parental reproductive performance and development of pups in a three-generation reproductive toxicity study by the oral route (feeding) with rats (ACGIH (7th, 2006)). However, in a teratogenicity test by oral gavage with rabbits, increased post-implantation loss was observed at a dose which causes mild toxicity to the maternal animals, and in a teratogenicity test by oral gavage with mice, dilated 4th brain ventricles and other visceral malformations were observed in fetuses at lower doses than those at which maternal toxicity was seen (HSDB (Access on June 2014)). Since the report that a fetus was affected is the information in List 2, there is no reliable evidence to enable classification in Category 1B. Therefore, it was classified in Category 2. |
8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system) |
Danger |
H370 |
P308+P311
P260 P264 P270 P321 P405 P501 |
In humans, nausea, vomiting, salivation, sweating, cardiopulmonary arrest, muscle fasciculations, low blood pressure, miosis, giddiness, blurred vision, profuse salivary and bronchial secretions were observed due to accidental ingestion of this substance and nervous system disorder was suggested (ACGIH (7th, 2006), HSDB (Access on June 2014)). Doses of 4.6-46 mg/kg of this article administered orally to rats elicited the appearance of rapid nervous system effects such as fasciculations, tremors, salivation, exophthalmos and labored respiration, and congestion of the liver, kidney and adrenal gland was observed in dead animals. Autopsy of survivors showed no effects (ACGIH (7th, 2006)). These nervous system effects were observed in the guidance value range corresponding to Category 1. In addition, this substance causes neurological symptoms due to cholinesterase inhibition, and when administered orally in rats, this substance has a nervous system damage action due to acetylcholinesterase inhibiting action. From the above, it was classified in Category 1 (nervous system). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system), Category 2 (liver, small intestine) |
Danger Warning |
H372
H373 |
P260
P264 P270 P314 P501 |
In humans, there is no finding of the harmful effects from repeated exposure to this substance, but there are concerns that many of the organophosphorus pesticides including this substance have a cholinesterase inhibiting action and cause nervous system toxicity (IPCS PMI (G001) (1998), HSDB (Access on June 2014)). In experimental animals, from the description that in a 2-year feeding study with dogs, inhibition of red blood cell cholinesterase, nervous system symptoms (tremors, salivation, lacrimation) and an increase in liver weight occurred in the 1.5 mg/kg/day dose group, and microscopic lesions of the liver and small intestines (details unknown) occurred in the 12 mg/kg/day dose group (IRIS (1991), EPA Pesticide (1999), ACGIH (7th, 2006)), it was classified in Category 1 (nervous system) and Category 2 (liver, small intestine). Besides, the doses that affected the target organs in experimental animals are as described above, and the target organs are the same as in the previous classification, but the classification of "liver" and "small intestine" is revised from Category 1 to Category 2 in the current classification. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment (Long-term) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
|