GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 944-22-9
Chemical Name O-Ethyl S-phenyl ethylphosphonothiolothionate (fonofos)
Substance ID H26-B-014, -
Classification year (FY) FY2014
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - From an initial melting point lower than 20 deg C, it is a liquid (GHS definition).
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Not classified
-
-
- - It was classified as "Not classified" from a flash point of 94 deg C (closed cup) above 93 deg C (ICSC (1997)).
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties (P-O of phosphoric acid is not self-reactive).
9 Pyrophoric liquids Classification not possible
-
-
- - No data available.
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- - From the information of water solubility: insoluble (ICSC (1997)), it is confirmed that it does not react vigorously with water.
13 Oxidizing liquids Classification not possible
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the element other than carbon or hydrogen (P). However, the classification is not possible due to no data.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- - No data available. Besides, it is described that is is corrosive to mild steel (HSDB (Access on Aug 2014)).

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 2


Danger
H300 P301+P310
P361+P364
P264
P270
P321
P330
P405
P501
There are three reports of LD50 values for rats, 8 mg/kg (IPCS, PIM (G001) (1998)), 3.8-8.0 mg/kg (female), 6.8-18.5 mg/kg (male) (ACGIH (7th, 2006)). According to the revised GHS classification guidance for the Japanese government, it was classified in Category 2 to which the largest number of data corresponds. Besides, since there is no description of this substance in PATTY (6th, 2012), a revised version of PATTY (5th, 2001) which was the basis of the previous classification, the data was deleted, and the category was revised.
1 Acute toxicity (Dermal) Category 1


Danger
H310 P302+P352
P262
P264
P270
P280
P310
P321
P361
P364
P405
P501
There are two reports of LD50 values for rats of 147 mg/kg (ACGIH (7th, 2006)) and for rabbits of 25 mg/kg (ACGIH (7th, 2006)). Since the numbers corresponding to Category 1 and Category 2 are the same, it was classified in Category 1 with the minimum LD50 value. The data of new information sources (ACGIH (7th, 2006)) were added and the category was revised.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition). Since inhalation in gaseous form cannot be assumed, it was classified as "Not classified"
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Category 2


Danger
H330 P304+P340
P403+P233
P260
P271
P284
P310
P320
P405
P501
Based on LC50 (4 hours) of 0.460 mg/L and LC50 (1 hour) of 0.900 mg/L (converted 4-hour equivalent value: 0.225 mg/L) for rats (ACGIH (7th, 2006)), it was classified in Category 2. Besides, since the exposure concentration is higher than the saturated vapor pressure concentration (0.005 mg/L), the reference value for the mist was applied.
2 Skin corrosion/irritation Not classified
-
-
- - Based on the description that this substance did not show skin irritation to rabbits (ACGIH (2006)), it was classified as "Not classified."
3 Serious eye damage/eye irritation Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, it is described that in a test with rabbits, eye irritation was observed but was negligible (ACGIH (2006)).
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a mouse bone marrow micronucleus test (HSDB (Access on June 2014)). As for in vitro, there are both negative and positive results in bacterial reverse mutation tests and a chromosomal aberration test with cultured mammalian cells (ACGIH (7th, 2006), HSDB (Access on June 2014)).
6 Carcinogenicity Classification not possible
-
-
- - Since it was classified in A4 in ACGIH (ACGIH (7th, 2006)) and in Group E in EPA (EPA Pesticide (1999)), the classification of ACGIH was prioritized and it was classified as "Classification not possible."
7 Reproductive toxicity Category 2


Warning
H361 P308+P313
P201
P202
P280
P405
P501
There is a report that there was no abnormality in parental reproductive performance and development of pups in a three-generation reproductive toxicity study by the oral route (feeding) with rats (ACGIH (7th, 2006)). However, in a teratogenicity test by oral gavage with rabbits, increased post-implantation loss was observed at a dose which causes mild toxicity to the maternal animals, and in a teratogenicity test by oral gavage with mice, dilated 4th brain ventricles and other visceral malformations were observed in fetuses at lower doses than those at which maternal toxicity was seen (HSDB (Access on June 2014)). Since the report that a fetus was affected is the information in List 2, there is no reliable evidence to enable classification in Category 1B. Therefore, it was classified in Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
In humans, nausea, vomiting, salivation, sweating, cardiopulmonary arrest, muscle fasciculations, low blood pressure, miosis, giddiness, blurred vision, profuse salivary and bronchial secretions were observed due to accidental ingestion of this substance and nervous system disorder was suggested (ACGIH (7th, 2006), HSDB (Access on June 2014)).
Doses of 4.6-46 mg/kg of this article administered orally to rats elicited the appearance of rapid nervous system effects such as fasciculations, tremors, salivation, exophthalmos and labored respiration, and congestion of the liver, kidney and adrenal gland was observed in dead animals. Autopsy of survivors showed no effects (ACGIH (7th, 2006)). These nervous system effects were observed in the guidance value range ​​corresponding to Category 1.
In addition, this substance causes neurological symptoms due to cholinesterase inhibition, and when administered orally in rats, this substance has a nervous system damage action due to acetylcholinesterase inhibiting action. From the above, it was classified in Category 1 (nervous system).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system), Category 2 (liver, small intestine)


Danger
Warning
H372
H373
P260
P264
P270
P314
P501
In humans, there is no finding of the harmful effects from repeated exposure to this substance, but there are concerns that many of the organophosphorus pesticides including this substance have a cholinesterase inhibiting action and cause nervous system toxicity (IPCS PMI (G001) (1998), HSDB (Access on June 2014)). In experimental animals, from the description that in a 2-year feeding study with dogs, inhibition of red blood cell cholinesterase, nervous system symptoms (tremors, salivation, lacrimation) and an increase in liver weight occurred in the 1.5 mg/kg/day dose group, and microscopic lesions of the liver and small intestines (details unknown) occurred in the 12 mg/kg/day dose group (IRIS (1991), EPA Pesticide (1999), ACGIH (7th, 2006)), it was classified in Category 1 (nervous system) and Category 2 (liver, small intestine).
Besides, the doses that affected the target organs in experimental animals are as described above, and the target organs are the same as in the previous classification, but the classification of "liver" and "small intestine" is revised from Category 1 to Category 2 in the current classification.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) -
-
-
- - -
11 Hazardous to the aquatic environment (Long-term) -
-
-
- - -
12 Hazardous to the ozone layer -
-
-
- - -


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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