GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 75-08-1
Chemical Name Ethanethiol
Substance ID H26-B-012, R-004
Classification year (FY) FY2014
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Category 1


Danger
H224 P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
It was classified in Category 1 based on a flash point of -48.3 deg C (closed cup) (HSDB (Access on July 2014)) and a boiling point of 35 deg C (ICSC (2014)). Besides, it is classified in Class 3, PG I (UN2363) in UNRTDG.
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 299 deg C (ICSC (2014)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Organic substances containing no oxygen, fluorine or chlorine
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to low-temperature-boiling liquids are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P362+P364
P264
P270
P330
P501
Based on a report of an LD50 value of 682 mg/kg for rats (PATTY (6th, 2012), SIDS (2012), DFGOT vol. 21 (2005)), it was classified in Category 4.
1 Acute toxicity (Dermal) Not classified
-
-
- - Based on reports of an LD50 value of >2,000 mg/kg for rats (SIDS (2012), PATTY (6th, 2012)) and an LD50 value of >2,000 mg/kg for rabbits (DFGOT vol. 21 (2005)), it was classified as "Not classified." New information sources (SIDS (2012), PATTY (6th, 2012), DFGOT vol. 21 (2005)) were added, and the category was revised.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 4


Warning
H332 P304+P340
P261
P271
P312
Based on reports of LC50 values (4 hours) of 2,770 ppm (ACGIH (7th, 2004)) and 4,420 ppm (PATTY (6th, 2012), SIDS (2012), DFGOT vol. 21 (2005)) for rats, it was classified in Category 4. Besides, since the LC50 values were lower than 90% of the saturated vapor concentration (5.81*106 ppm), the reference value in units of ppm was applied as a vapour without a mist.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Not classified
-
-
- - There is a report that, in a test in which rabbits were applied to this substance for 4 hours, moderate (score 2) erythema was observed and slight irritation was confirmed (SIDS (2012), PATTY (6th, 2012)). In addition, there is a report that, in a test with rats, irritation and skin discoloration were observed, but this eventually disappeared (PATTY (6th, 2012)). From the above results, it was classified as "Not classified" (Category 3 in UN GHS classification). The category was changed according to the revised GHS classification guidance for the Japanese government.
3 Serious eye damage/eye irritation Category 2B
-
Warning
H320 P305+P351+P338
P337+P313
P264
There was a report of mild irritation in a Draize test with rabbits (SIDS (2012), PATTY (6th, 2012)). From the above result, it was classified in Category 2B. The information (RTECS) in List 3 was deleted, and the category was revised.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data. There were no in vivo data. As for in vitro, there are reports that it was negative in bacterial reverse mutation tests (SIDS (2012)), and that it was equivocal or ambiguous in mouse lymphoma tests (SIDS (2012), DFGOT vol. 21 (2005)).
6 Carcinogenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system), Category 3 (respiratory tract irritation, narcotic effects)



Danger
Warning
H370
H335
H336
P308+P311
P260
P264
P270
P321
P405
P501
P304+P340
P403+P233
P261
P271
P312
In humans, in reports from an exposure study with volunteers and from an accidental exposure through the inhalation route, vomiting, headache, fatigue and irritation of mucous membranes of the mouth and nose were reported after 3-hour exposure at 4 ppm (SIDS (2012), ACGIH (7th, 2004), DFGOT vol. 21 (2005)), and additionally, weakness, fatigue, incoordination, dizziness, tremor, unconsciousness and irritation of the upper respiratory tract mucosa were observed (HSDB (Access on June 2014)).
Through the inhalation route, there are reports of transient chromodacryorrhea, nasal secretion and respiratory distress were observed in a 4-hour exposure in rats at 991 ppm, and irritation of nasal mucosal membrane, increased respiration, restlessness, uncoordinated movement, staggering gait, muscular weakness, skeletal muscle paralysis, cyanosis, sedation and death in a 4-hour exposure in rats at 2,600-5,125 ppm (SIDS (2012), DFGOT vol. 21 (2005)), and loss of the righting reflex in a 15-minute exposure in rats at 33,000 ppm (PATTY (6th, 2012)). Through the oral route, there is a report that sedation was observed by administration of 210-3,360 mg/kg (no description of dose level) (SIDS (2012)). In addition, in HSDB (Access on June 2014), there are descriptions that this substance showed narcotic effects in rats and mice, and that respiratory depression, cyanosis, central nervous system depression (muscular weakness, incoordination, coma) and death were observed.
From the above, this substance caused effects on the central nervous system, respiratory tract irritation and narcotic effects, and in addition to effects on humans, the effects on rats by both the inhalation and oral routes were observed within the guidance value range corresponding to Category 1. Therefore, it was classified in Category 1 (central nervous system), Category 3 (respiratory tract irritation, narcotic effects).
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - In humans, there is a description that when volunteers were exposed to this substance at 10 mg/m3 (4 ppm) by inhalation for 3 hours for 5 to 10 days, olfactory hypesthesia (a rise in the olfactory threshold), altered taste reaction to bitter and sweet substances, nausea, irritation of mucous membranes of the lips, mouth and nose were observed (ACGIH (7th, 2001; 2004), DFGOT vol. 21 (2005), SIDS (2012)). However, all these findings were considered to be due to mucosa irritation or respiratory tract irritation from this substance.
As for experimental animals, although there were test data by repeated inhalation exposure with rats, mice and rabbits (ACGIH (7th, 2001; 2004), DFGOT vol. 21 (2005), SIDS (2012)), no details were described, and the reliability of all these was judged invalid in SIDS (2012). Therefore, it was considered that there were no suitable data for classification.
From the above, it was not possible to identify clear target organs through the inhalation route, and there was no toxicity information by the other route. Therefore, it was classified as "Classification not possible" due to lack of data.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1


Warning
H400 P273
P391
P501
It was classified in Category 1 from 48-hour EC50 = 0.077 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1998)).
11 Hazardous to the aquatic environment (Long-term) Category 1


Warning
H410 P273
P391
P501
If chronic toxicity data are used, then it is classified in Category 1 due to not being rapidly degradable (a degradation rate by BOD = 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2002)), and 21-day NOEC = 0.009 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1998)).
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to not being rapidly degradable (a degradation rate by BOD = 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2002)), and 96-hour LC50 = 2.2 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1998), SIDS, 2010).
By drawing a comparison between the above results, it was classified in Category 1.
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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