GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 104-90-5
Chemical Name 5-Ethyl-2-methylpyridine
Substance ID 25B0060
Classification year (FY) FY2013
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2009  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Category 4
-
Warning
H227 P370+P378
P403+P235
P210
P280
P501
It was classified in Category 4 from a flash point of 70 deg C (closed-cup) (SIDS (1994)).
7 Flammable solid Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 939 deg F (HSDB (Access on December 2013)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Organic compounds containing no oxygen, fluorine or chlorine.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule.
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
It was classified in Category 4 based on a report on LD50 values for rats of 1,737 mg/kg, 710 mg/kg, and 918-2,295 mg/kg (SIDS (2005)).
1 Acute toxicity (Dermal) Category 3


Danger
H311 P302+P352
P361+P364
P280
P312
P321
P405
P501
It was classified in Category 3 based on a report on an LD50 value of 1,000 mg/kg for rabbits (SIDS (2005)).
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, it is reported that there were no death cases in rats at 1,700 ppm (3 hours) (converted 4-hour equivalent value: 1,472 ppm) (PATTY (6th, 2012)), and there is a report on an LC100 value (3.7 hours) for rats of 1,700 ppm (converted 4-hour equivalent value: 1,635 ppm) (SIDS (2005)). The above was judged to be tested on a vapour because the test concentrations were lower than 90% of the saturated vapour pressure concentration (1,829 ppm).
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, it is reported that there are death cases in rats at each of 12,000 ppm (1 hour and 40 minutes) (converted 4-hour equivalent value: 14.9 mg/L and 9.9 mg/L) and 4,000 ppm (4 hours and 20 minutes) (converted 4-hour equivalent value: 19.8 mg/L and 1.65 mg/L) (PATTY (6th, 2012)). Besides, because the test concentrations were higher than the saturated vapour pressure concentration (1,829 ppm), a reference value in the unit of mg/L was applied as mist.
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
It is reported in SIDS (2005) that in a test with rabbits (OECD TG404), a black discoloration was noted at all application sites one hour after the removal of wrapping, the skin became hard and indented on day 1, and the skin surrounding the application sites showed slight to moderate edema and moderate to severe erythema, therefore it was judged to be corrosive. And it is described in PATTY (6th, 2012) that this substance is a skin irritant. It was classified in Category 1 based on the above information.
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
It was classified in Category 1 because it is described in PATTY (6th, 2012) that this substance is a severe eye irritant, and it was judged as corrosive to the skin in SIDS (2005).
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, it is described in PATTY (6th, 2012) that it did not produce skin sensitization in a test with guinea pigs, but the details on the test method, the number of sensitized animals, etc. are unknown.
5 Germ cell mutagenicity Classification not possible
-
-
- - It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a micronucleus test with mouse bone marrow cells (SIDS (2005)), and as for in vitro, it was negative in a bacterial reverse mutation test, and there is a positive result in the absence of S9 mix in a chromosomal aberration test with human lymphocytes, but this is the knowledge at the dose close to the cytotoxic dose, and both two tests conducted at appropriate doses were negative (SIDS (2005)).
6 Carcinogenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
7 Reproductive toxicity Category 2


Warning
H361 P308+P313
P201
P202
P280
P405
P501
In a reproduction/developmental toxicity screening test (OECD draft TG421) with rats in the oral route (gavage), total litter loss (3 animals), lower body weights and a decrease in viability of the offspring were observed at the dose (300 mg/kg/day) where general toxicity occurred in parent animals, including reduced weight gain, salivation, and lesions in the liver, kidney, and spleen (SIDS (2005)). Therefore, it was classified in Category 2.
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects)


Warning
H336 P304+P340
P403+P233
P261
P271
P312
P405
P501
It was classified in Category 3 (narcotic effects) because lethargy, piloerection, ataxia, tachypnea, etc. are reported after oral administration (250-1,020 mg/kg) to rats (SIDS (2005)). Besides, the information in PATTY (cyanosis, emphysema of the lung, congestion, edema) in the previous classification was not described here because the details are unknown as to whether they were the findings in the surviving animals.
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - It is described that in a 28-day gavage administration test with rats, decreases in weight gain and food consumption, increase weights of the liver and kidney, and increases in blood urea nitrogen, creatinine, and AST activity were observed (no descriptions of the sex in any of the findings) at the doses (95-300 mg/kg/day; converted guidance value: 29.6-93.3 mg/kg/day) corresponding to Category 2 (SIDS (2005)). Therefore, the liver and kidney are candidates for the target organ, but as for the liver, no pathological findings were accompanied, the related findings were limited to an increase in blood AST activity (the sex and grade: unknown), and no serious toxicity changes were included. And as for the kidney, hyaline droplet nephropathy was seen in males, and because it is regarded as a phenomenon specific to male rats and not applicable to humans, it was difficult to take the kidney as the target organ. Therefore, the target organ could not be identified concerning decreased weight gain, there are no descriptions of the severity of the decrease in weight gain in SIDS, and it was estimated that there were no severe toxicity effects as a whole at up to the dose close to the upper limit for Category 2. From the above, it falls under "Not classified" in the oral route. However, because of no toxicity information on the other routes, it was classified as "Classification not possible" due to lack of data.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3
-
-
H402 P273
P501
It was classified in Category 3 from 48-hour EC50 = 39.6 mg/L for crustacea (Daphnia magna) (SIDS, 2005).
11 Hazardous to the aquatic environment (Long-term) Category 3
-
-
H412 P273
P501
If chronic toxicity data are used, then it is classified in Category 3 due to rapid degradability (a degradation rate by OECD301E: 77% (SIDS, 2005)), and 72-hour NOEC = 0.689 mg/L for algae (Pseudokirchneriella subcapitata) (SIDS, 2005).
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, there are data: 48-hour EC50 = 39.6 mg/L for crustacea (Daphnia magna) (SIDS, 2005). However, it is rapidly degradable (a degradation rate by OECD301E: 77% (SIDS, 2005)), and low bioaccumulation is estimated (log Kow = 2.27-2.52 (SIDS, 2005)). Therefore, it is classified as "Not classified."
By drawing a comparison between the above results, it was classified in Category 3.
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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