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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	504-60-9
Chemical Name	Penta-1,3-diene
Substance ID	25B0056
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2010
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It was classified in Category 2 from a flash point of -29 deg C (closed-cup) (HSDB (Access on December (2013))) and a boiling point of 42 deg C (ICSC (2008)).
7	Flammable solid	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is a chemical group associated with self-reactive properties (unsaturated bond) present in the molecule, but the classification is not possible due to no data. Besides, the one which is added a stabilizer, BHT (SIDS (2002)) is defined as Type G.
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available.
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to low-temperature-boiling liquids are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	It was classified as "Not classified" (Category 5 in UN GHS classification) because it is described in SIDS (2002) that an LD50 value was < 5,000 mg/kg for rats (OECD TG 401), but from > 1,000 mg/kg of a preliminary test result, an LD50 value was estimated to be > 2,000 mg/kg.
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" based on a report on an LD50 value of > 3,200 mg/kg for rabbits (OECD TG 402) (SIDS (2002)). Besides, no death was observed after the application of 3,200 mg/kg (SIDS (2002)).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not classified	- -	-	-	It was classified as "Not classified" based on a report on an LC50 value (4 hours) of > 20,917 ppm (= 58.2 mg/L) for rats (OECD TG 403) (SIDS (2002)). Besides, because the test concentration (20,917 ppm) was lower than 90% of the saturated vapour pressure concentration (526,159 ppm), a reference value in the unit of ppm was applied as a vapour without mist.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, it is described in SIDS (2002) that moderate irritation was observed in an acute dermal toxicity test in which 3,200 mg/kg was applied to rabbits for 24 hours, but it was not adopted because of using a high application amount and long application time.
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, it is described in SIDS (2002) that this substance is not expected to be a severe eye irritant from data on related compounds.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in micronucleus tests with bone marrow cells of mice and rats (SIDS (2002)), and as for in vitro, it was negative in a bacterial reverse mutation test, a mouse lymphoma test and a chromosomal aberration test with cultured mammalian cells (SIDS (2002), IUCLID (2000)).
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, isoprene, the isomer, was not carcinogenic at doses up to 7,000 ppm in an inhalation administration test with rats (SIDS (2002)).
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, it is reported in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats (OECD TG 422), no evidence of reproductive toxicity in parent animals was found, and there were almost no exposure effects on the development of offspring (SIDS (2002), IUCLID (2000)). However, because the test is a screening test, and there was no sufficient information on developmental toxicity, it was classified as "Classification not possible."
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	It was classified in Category 3 (respiratory tract irritation) because it is described that it is irritating to the respiratory tract in humans, and the threshold level causing hypoxia was 850-1,000 mg/m3 for this substance (IUCLID (2000)).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	It is described that in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats, no toxicity effects were observed even after the oral administration of a limit dose (1,000 mg/kg/day) (SIDS (2002)), therefore it corresponds to "Not classified" in the oral route. However, because of no toxicity information on the other routes, the classification is not possible due to lack of data.
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Not classified	- -	-	-	It was classified as "Not classified" froom 96-hour ErC50 = 174.6 mg/L for algae (Pseudokirchneriella subcapitata), 48-hour EC50 = 221.5 mg/L for crustacea (Daphnia magna), and 96-hour LC50 = 139.9 mg/L for fish (Pimephales promelas) (all SIDS, 2002).
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	Reliable chronic toxicity data were not obtained. It was classified as "Not classified" because it is not water-insoluble (water solubility = 0.069 g/100 mL, ICSC, 2008), and it was classified as "Not classified" in acute toxicity.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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