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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	62-23-7
Chemical Name	p-Nitrobenzoic acid
Substance ID	25B0052
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2010
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Classification not possible	- -	-	-	There is a chemical group associated with explosive properties (nitro group) in the molecule, and the oxygen balance of -120 is more than the criteria of -200. However, the classification is not possible due to no data.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solid	Classification not possible	- -	-	-	No data available. Besides, it is described in ICSC (2008) that it is combustible.
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is a chemical group associated with explosive properties (nitro group) in the molecule, but the classification is not possible due to no data.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 300 deg C (ICSC (2008)).
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Classification not possible	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the element other than carbon or hydrogen (N). However, the classification is not possible due to no data.
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	It was classified in Category 4 based on a report on an LD50 value of 1,960 mg/kg for rats (NTP TR442 (1994)).
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Not classified	- -	-	-	It was classified as "Not classified" because it is reported that there was no irritation in a test with rabbits (OECD TG 404) (IUCLID (2000)).
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	It was classified in Category 2B because it is reported that there was slight irritation in a test with rabbits (OECD TG 405) (IUCLID (2000)).
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. As for in vivo, it was negative in a micronucleus test with mouse peripheral blood erythrocytes and a chromosomal aberration test with bone marrow cells of Chinese hamsters (NTP TR442 (1994), IUCLID (2000), NTP DB (Access on September 2013)), and as for in vitro, it was positive in a bacterial reverse mutation test, and a chromosomal aberration test with cultured mammalian cells (NTP TR442 (1994), IUCLID (2000), NTP DB (Access on September 2013)), and negative in an hgprt gene mutation test (IUCLID (2000)).
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, it is reported that in 2-year diet administration tests with rats and mice, there was no evidence of carcinogenicity in male rats, increases in the incidences of clitoral gland adenoma and clitoral gland adenoma or carcinoma (combined) were observed in female rats, and there was no evidence of carcinogenicity in both sex of mice (NTP TR442 (1994)).
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	In a continuous breeding test with mice by diet administration during a 7-day pre-copulation period and a 98-day copulation period, a dose-dependent impairment of both fertility and reproduction occurred, and almost all reproductive parameters were adversely affected. As a result of cross-over mating, effects on the female reproductive system were shown (NTP TR442 (1994), NTIS PB90-253766 (1990)). Because the above effects were also observed in the dose group that did not show reduced weight gain as general toxicity, it was classified in Category 1B.
8	Specific target organ toxicity - Single exposure	Category 2 (haemal system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	In an acute oral toxicity test with rats, infiltration of red blood cells in the liver and myeloid metaplasia of the red pulp of the spleen are reported in the group given 1,960 mg/kg (NTP TR442 (1994)). Furthermore, similar findings were obtained after oral administration to mice (IUCLID (2000)). And it is reported that methemoglobin formation and hematopoietic toxicity are found after the administration of aromatic nitro compounds, and this toxicity is often more severe in rats than in mice (NTP TR442 (1994)). It was classified in Category 2 (blood system) based on the above knowledge.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In 13-week diet administration tests with rats and mice, no toxicity effects were observed even after exposure to the doses within the guidance value range for Category 2. However, in rats, effects on the spleen (congestion, deposition of pigment (hemosiderin), increased weights) and kidney (deposition of pigment (hemosiderin), increased weights) were found from the high dose of 2,500 ppm (170 mg/kg/day) corresponding to "Not classified," and effects on the blood system (increases in methemoglobin, Heinz bodies, and reticulocyte counts, decreases in erythrocyte counts, hemoglobin, and hematocrit values) and testis (atrophy of the seminiferous tubules) were also seen at 10,000 ppm (660-680 mg/kg/day). And in 2-year diet administration tests, no non-neoplastic lesions were observed in rats at up to 2,500 ppm (100-125 mg/kg/day) and in mice at up to 5,000 ppm (675-905 mg/kg/day) (NTP TR442 (1994)). Therefore, it corresponds to "Not classified" in the oral route. However, because of no toxicity information on the other routes, the classification is not possible due to lack of data.
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Not classified	- -	-	-	It was classified as "Not classified" from 96-hour LC50 > 500 mg/L for fish (Danio rerio) (IUCLID, 2000).
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	Reliable chronic toxicity data were not obtained. It was classified as "Not classified" because it is not water-insoluble (water solubility = 200 mg/L, HSDB, 2013), and it was classified as "Not classified" in acute toxicity.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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