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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	10102-44-0
Chemical Name	Nitrogen dioxide
Substance ID	25B0048
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	Gas (GHS definition)
2	Flammable gases (including chemically unstable gases)	Not classified	- -	-	-	Not combustible (HSDB (Access on September 2013)).
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Category 1	Danger	H270	P370+P376 P220 P244 P403	This substance is an oxidizing gas listed in ISO 10156-2010. It is classified in Division 2.3 (Subsidiary Risk 5.1, 8) (UN1067) in UNRTDG.
5	Gases under pressure	Liquefied gas	Warning	H280	P410+P403	From a critical temperature (157.8 deg C (HSDB (Access on September 2013))) above +65 deg C, it was classified as liquefied gas (low pressure liquefied gas).
6	Flammable liquids	Not applicable	- -	-	-	Gas (GHS definition)
7	Flammable solid	Not applicable	- -	-	-	Gas (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	Gas (GHS definition)
9	Pyrophoric liquids	Not applicable	- -	-	-	Gas (GHS definition)
10	Pyrophoric solids	Not applicable	- -	-	-	Gas (GHS definition)
11	Self-heating substances and mixtures	Not applicable	- -	-	-	Gas (GHS definition)
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	Gas (GHS definition)
13	Oxidizing liquids	Not applicable	- -	-	-	Gas (GHS definition)
14	Oxidizing solids	Not applicable	- -	-	-	Gas (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	It is an inorganic compound.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to gas substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not applicable	- -	-	-	Gas (GHS definition)
1	Acute toxicity (Dermal)	Not applicable	- -	-	-	Gas (GHS definition)
1	Acute toxicity (Inhalation: Gases)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	It was classified in Category 1 based on a report on an LC50 value (1 hour) for rats of 115 mL/m3 (converted 4-hour equivalent value 57.5 ppm) (DFGOT vol. 21 (2005)) and an LC50 value (4 hours) for rats of 88 ppm (HSDB (Access on September 2013)).
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Gas (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Not applicable	- -	-	-	Gas (GHS definition)
2	Skin corrosion/irritation	Classification not possible	- -	-	-	It is described in ACGIH (7th, 2012) that available data were not available to recommend a SKIN notation for this substance. And this substance is classified in "C; R34" in EU DSD classification and "Skin Corr. 1B H314" in EU CLP classification. Among the above information, by prioritizing the information in ACGIH (7th, 2012), the information source in List 1, it was classified as "Classification not possible." ACGIH, EU DSD classification, and EU CLP classification obtained in this investigation were added, and the classification was reviewed.
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	It is described in DFGOT vol. 21 (2005) that this substance was irritating to the eye in rats and rabbits (no description on details). And it is described in HSDB (Access on September 2013) that this substance of 10-20 ppm can cause eye irritation in humans, and this substance of higher concentrations (described as vapour in HSDB) can cause eye injury. It was classified in Category 2 from the above information. Besides, it was classified in "C; R34" in EU DSD classification and "Skin Corr. 1B H314" EU CLP classification. DFGOT, HSDB, EU DSD classification, and EU CLP classification obtained in this investigation were added, and the classification was reviewed.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a chromosomal aberration test with mouse spermatocytes, a chromosomal aberration test with mouse peripheral blood lymphocytes, and a micronucleus test with mouse bone marrow cells (EHC 188 (1997), ACGIH (7th, 2012)). On the other hand, it was positive in a DNA damage test (DNA strand break) with mouse lung cells (EHC 188 (1997)), but the in-vivo effect was considered to be limited to the respiratory tract (DFGOT Vol. 21 (2005)). As for in vitro, it was negative in a gene mutation test with cultured mammalian cells (EHC 188 (1997)) and a micronucleus test with cultured human nasal epithelial cells (HSDB (Access on September 2013)), but there are positive results in a bacterial reverse mutation test, a chromosomal aberration test with cultured cells (EHC 188 (1997)), and a DNA damage test (comet assay) with cultured human nasal epithelial cells (HSDB (Access on September 2013)), and it was judged to be positive in vitro in DFGOT and ACGIH.
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was classified in A4 in ACGIH (7th, 2012). The category was changed according to the revised GHS classification guidance for the Japanese government.
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	It was classified in Category 2 because it is described in EHC 188 (1997), DFGOT vol. 21 (2005) that clear reproductive toxicity (an increase in post-implantation lethality) was observed at the dose where general toxicity was seen in maternal animals in an inhalation test with rats exposed during gestation.
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs), Category 3 (narcotic effects)	Danger Warning	H370 H336	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	In cases of humans exposed to this substance, it is described that effects on lung function and the respiratory organs were observed (ACGIH (7th, 2012), PATTY (6th, 2012), EHC 188 (1997)), and lung injury was permanent (ACGIH (7th, 2012)). Therefore, it was classified in Category 1 (respiratory system). And it was classified in Category 3 (narcotic effects) because somnolence and vertigo were found in humans (PATTY (6th, 2012)). As a result of investigating the updated information, effects were seen in the respiratory tract, larynx, bronchus, etc. in addition to the lung, therefore the target organs were changed to the respiratory system. And Category 3 (narcotic effects) was added because somnolence and vertigo were observed.
9	Specific target organ toxicity - Repeated exposure	Category 1 (lung, immune system)	Danger	H372	P260 P264 P270 P314 P501	It was classified in Category 1 (lung) because it is described that long-tern exposure causes lung disease in humans (ACGIH (7th, 2001), EHC 188 (1997), PATTY (6th, 2012)), and the expansion of the alveoli was observed at the concentration (0.5 ppm) within the guidance value range for Category 1 after repeated inhalation exposure in mice for 3-12 months (ACGIH (7th, 2001)). Furthermore, from the description that in a test in which monkeys were exposed by inhalation at 5 ppm for 2 months or at 10 ppm for 1 month, mortality from infection of bacteria (Klebsiella pneumoniae) or influenza virus increased in the exposed groups, and a marked decrease in resistance to infections was found (the original article (Henry, M.C. et al. (1970)) quoted in ACGIH (7th, 2001) was obtained, and the content was confirmed), and the description that in a 6-month inhalation test with rats exposed at 1 ppm, decreased levels of all serum immunoglobulins and complements were observed (EHC 188 (1997)), it is pointed out that long-term inhalation exposure to this substance may cause a decrease in host defenses in the respiratory system or immunosuppression in humans (PATTY (6th, 2012), EHC 188 (1997)). Therefore, Category 1 (immune system) was added from the animal test results.
10	Aspiration hazard	Not applicable	- -	-	-	Gas (GHS definition)

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Classification not possible	- -	-	-	The classification is not possible because appropriate data are not obtained.
11	Hazardous to the aquatic environment (Long-term)	Classification not possible	- -	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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