Item | Information |
---|---|
CAS RN | 7681-57-4 |
Chemical Name | Sodium disulfite (solid) |
Substance ID | 25B0043 |
Classification year (FY) | FY2013 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance by the Japanese Government (July, 2013) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
7 | Flammable solid | Not classified |
- |
- | - | Not combustible (HSDB (Access on September 2013)). |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
10 | Pyrophoric solids | Not classified |
- |
- | - | Not combustible (HSDB (Access on September 2013)). |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | Not combustible (HSDB (Access on September 2013)). |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | From information on water solubility: 54 g/100 mL (ICSC (2002)), it is recognized that it does not react vigorously with water. |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
14 | Oxidizing solids | Not classified |
- |
- | - | It is a reducing agent (ICSC (2002)). |
15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic substance. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
It was classified in Category 4 based on an LD50 value for rats of 1,540 mg/kg (SIDS (2001), EPA Pesticides (2007)). Besides, there are other LD50 values of 1,131 mg/kg (EPA Pesticides (2007)) and 2,480 mg/kg (SIDS (2001)). |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | It was classified as "Not classified" based on an LD50 value of > 2,000 mg/kg for rats (EPA Pesticides (2007)). The category was revised based on data in EPA Pesticides (2007) obtained in this investigation. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. This substance was not irritating in a test with rabbits (SIDS (2001), IUCLID (2000)). On the other hand, sufficient information was not observed in humans. Furthermore, it is described in the summary of ACGIH (7th, 2001) that sufficient data were not available to recommend a Skin notation for this substance. |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
Because an eye irritation/corrosion test with rabbits (according to OECD TG 405) resulted in "irritating, risk of serious damage to the eye," it is concluded in SIDS (2001) that it is an eye irritant. And this substance is classified in "Xi: R41" in EU DSD classification and "Eye Dam. 1 H318" in EU CLP classification. It was classified in Category 1 based on the above information. It was impossible to track the data in ECETOC TR 66, which was used as the rationale in the previous classification. The classification was revised based on the newly obtained information. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Respiratory sensitization: Classification not possible due to lack of data. Two cases of occupational asthma in laundry workers exposed to this substance are reported, and it is reported that a 67-year-old woman who ate vinegar containing this substance as a preservative developed severe asthma (ACGIH (7th, 2001)). However, it is described in the summary of ACGIH (7th, 2001) that sufficient data were not available to recommend a SEN notation for this substance. It is described in SIDS (2001) that urticaria, asthma with itching, edema, rhinitis, and nasal congestion are reported in humans, but immunological pathogenesis of these is not clear. And it is described in SIDS (2001) that this substance is unlikely to induce respiratory sensitization but may enhance symptoms of asthma in sensitive individuals, however, given the wide-spread use, the number of cases is considered to be low. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. It is described in SIDS (2001) that no indication of skin sensitization with guinea pigs was observed in a non-guideline study. And it is described that positive patch testing and allergic contact dermatitis were observed in a few cases, but concerning wide-spread use, this substance is not considered as a skin sensitizer. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. As for in vivo, it was negative in all of a dominant lethal test with rats, micronucleus tests with mice and hamsters, chromosomal aberration tests and sister chromatid exchange tests with rats, mice, and Chinese hamsters (SIDS (2001), HSDB (Access on September 2013)). As for in vitro, negative and positive results were mixed in bacterial reverse mutation tests and chromosomal aberration tests with cultured mammalian cells (SIDS (2001), HSDB (Access on September 2013)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | It was assessed as A4 in ACGIH (1995). And disulfites were assessed as Group 3 in IARC 54 (1992). The category was changed according to the GHS classification guidance for the Japanese government. |
7 | Reproductive toxicity | Not classified |
- |
- | - | It was classified as "Not classified" because no reproductive or developmental toxicity was observed in a multi-generation test with rats (ACGIH (7th, 2001), IARC 54 (1992), SIDS (2001)) and developmental toxicity tests with rats and rabbits (SIDS (2001)). |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
It was classified in Category 3 (respiratory tract irritation) because it is described that it causes inflammation of the throat in humans (HSDB (Access on September 2013)), and irritation of the upper respiratory organ was observed in mice (ACGIH (7th, 2001)). |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, the classification result was changed from the previous classification because it was determined that asthma cases were described in respiratory sensitization and were not included in repeated exposure effects. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 3 |
- |
H402 |
P273
P501 |
It was classified in Category 3 from 72-hour EC50 = 48.1 mg/L for algae (Desmodesmus subspicatus) (SIDS, 2004). |
11 | Hazardous to the aquatic environment (Long-term) | Category 3 |
- |
H412 |
P273
P501 |
If chronic toxicity data are used, then it is classified as "Not classified" due to unknown behavior of the inorganic compound, this substance in water, and 21-day NOEC > 10 mg/L for crustacea (Daphnia magna) (SIDS, 2004). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 due to unknown behavior of the inorganic compound, this substance in water, and 72-hour EC50 = 48.1 mg/L for algae (Desmodesmus subspicatus) (SIDS, 2004). By drawing a comparison between the above results, it was classified in Category 3. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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