GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 7631-90-5
Chemical Name Sodium hydrogen sulfite (34% aqueous solution)
Substance ID 25B0042
Classification year (FY) FY2013
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Not classified
-
-
- - It is an aqueous solution.
7 Flammable solid Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- - It is an aqueous solution.
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- - It is an aqueous solution.
13 Oxidizing liquids Not classified
-
-
- - It is a reducing agent (ICSC (2006)).
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - It is an inorganic substance.
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, there is a report on an oral LD50 value of 1,400-2,000 mg/kg for rats on a 39% aqueous solution (GESTIS (Access on September 2013)). The average LD50 value of 1,310 mg/kg in the previous classification was based on reports in SIDS (2004), ACGIH (7th, 2001), RTECS (2004), but it was not adopted because they were reports on disodium disulfite (solid).
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Classification not possible due to lack of data.
[Refer to the classification for this hazard class for disodium disulfite (CAS: 7681-57-4).]
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, this substance was not irritating in animal tests (IUCLID (2000)), but there is the information that concentrated solutions are irritating in humans (HSDB (Access on September 2013)), and it is classified in Class 8 in UNRTDG.
3 Serious eye damage/eye irritation Category 2B
-
Warning
H320 P305+P351+P338
P337+P313
P264
As cases in humans, it is described that mild eye and respiratory responses are reported for this substance in the medical literature (ACGIH (7th, 2001)). As for animal experiments, there is the information that a test on an aqueous solution resulted in no irritation (IUCLID (2000)), but it is described in ACGIH (7th, 2001) that this substance was irritating to the eye (the intensity is not described). Because ACGIH is the information source in List 1, and IUCLID is the information source in List 2, the information in ACGIH was adopted, and the classification was revised to Category 2B.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data. There are no epidemiological information or case reports on this substance in humans, and no animal test reports, and it is described in the summary of ACGIH (2001) that sufficient data were not available to recommend a SEN notation for this substance.
[Refer to the classification for this hazard class for disodium disulfite (CAS: 7681-57-4).]
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data. There are no epidemiological information or case reports on this substance in humans, and no animal test reports, and it is described in the summary of ACGIH (2001) that sufficient data were not available to recommend a SEN notation for this substance.
[Refer to the classification for this hazard class for disodium disulfite (CAS: 7681-57-4).]
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data. There is no information on this substance. Besides, as information on sulfites, as for in vivo, they were negative in a dominant lethal test and a chromosomal aberration test with mice (ACGIH (7th, 2001)), and as for in vitro, there are positive results in a bacterial reverse mutation test and a gene mutation test with cultured mammalian cells (ACGIH (7th, 2001)), but this was not sufficient information on mutagenicity.
6 Carcinogenicity Classification not possible
-
-
- - This substance was assessed as A4 in ACGIH (1995). And bisulfites were assessed as Group 3 in IARC (1992). Therefore, this substance was classified as "Classification not possible" because the category was changed according to the revised GHS classification guidance for the Japanese government.
7 Reproductive toxicity Classification not possible
-
-
- - There are no reproductive or developmental toxicity data on this substance.
[Refer to the classification for this hazard class for disodium disulfite (CAS: 7681-57-4).]
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation)


Warning
H335 P304+P340
P403+P233
P261
P271
P312
P405
P501
It was classified in Category 3 (respiratory tract irritation) because it is described that it was irritating to the mucous membranes in animals, and there were mild respiratory responses in humans (ACGIH (7th, 2001)). The information used in the previous classification was deleted because it was from the information source in List 3 (GESTIS Access on September 2013), and the classification was newly conducted.
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, one death from neurologic degeneration was observed in persons with a genetic defect in sulfite oxidase (ACGIH (7th, 2001)), and a case of a pancreatitis patient who developed hypersensitivity reactions and a case of an asthmatic patient whose symptoms were exacerbated are reported (HSDB (Access on September 2013)), but all was a report on only one case, and the association with this substance exposure was unclear. Besides, the previous classification was conducted by using the asthma cases due to occupational exposure and consumer exposure as the rationale, but it was confirmed that they were not the cases from exposure to this substance (but the cases from exposure to disodium disulfite).
[Refer to the classification for this hazard class for disodium disulfite (CAS: 7681-57-4).]
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- - The classification is not possible because appropriate data are not obtained.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- - No data available.
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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