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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	2698-41-1
Chemical Name	2-Chlorobenzylidenemalononitrile
Substance ID	25B0041
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solid	Classification not possible	- -	-	-	No data available.
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	- -	-	-	The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen.
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	It was classified in Category 4 based on LD50 values for rats of 1,284 mg/kg (females) and 1,366 mg/kg (males) (ACGIH (7th, 2001)).
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	It was classified in Category 2 based on a report on a median lethal dose value of 88,480 mg-min/m3 (converted 4-hour equivalent LC50 value 0.37 mg/L) for rats (males) exposed to aerosol (ACGIH (7th, 2001), the original article: Ballantyne, B. et al. (1978)).
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	It was classified in Category 1 because it is described in ACGIH (7th, 2001) that this substance is an incapacitating agent used for riot control, and running nose, dizziness, nausea, vomiting, intense eye and skin irritation, coughing, difficulty in breathing, chest tightness, etc. occur when in contact with this substance.
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	It was classified in Category 1 because it is described in ACGIH (7th, 2001) that this substance is an incapacitating agent used for riot control, and running nose, dizziness, nausea, vomiting, intense eye and skin irritation, coughing, difficulty in breathing, chest tightness, etc. occur when in contact with this substance.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	It is reported that a skin sensitizing potential was observed in workers in the place where this substance was manufactured (ACGIH (7th, 2001)), but it is concluded in ACGIH (7th, 2001) that sufficient data were not available to recommend a SEN notation for this substance. Therefore, it was classified as "Classification not possible."
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. As for in vivo, it was negative in micronucleus tests with bone marrow cells of mice by oral or intraperitoneal administration (ACGIH (7th, 2001)). As for in vitro, bacterial reverse mutation tests were negative as a whole, but there were equivocal or weakly positive results (ACGIH (7th, 2001), NTP DB (Access on June 2013)), and it was reported to be positive in a mouse lymphoma test and a chromosomal aberration test with cultured mammalian cells (ACGIH (7th, 2001), NTP DB (Access on June 2013)).
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was judged as A4 in ACGIH (1995). Besides, it was negative in both males and females of mice and rats in inhalation carcinogenicity tests reported in NTP TR-377.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. No malformations or developmental effects were observed after inhalation exposure in pregnant rats and rabbits (ACGIH (7th, 2001)), but there are no fertility data.
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	In experiments in human volunteers on this substance (ACGIH (7th, 2001)), transient effects on the respiratory system such as coughing, difficulty in breathing, and chest tightness are reported in addition to incapacitation. Therefore, it was classified in Category 3 (respiratory tract irritation).
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	No adverse effects were observed after short-term (2 weeks) exposure to lower concentrations of this substance in human volunteers (ACGIH (7th, 2001)). In 13-week and 2-year inhalation exposure tests (dust) with rats and mice, damage of the nasal cavity (rats: metaplasia of the olfactory epithelium, etc. at or above 0.00025 mg/L, mice: suppurative inflammation, etc. at or above 0.00075 mg/L), larynx (rats: epithelial hyperplasia, etc. at or above 0.003 mg/L), trachea (rats: epithelial hyperplasia, etc. at or above 0.0015 mg/L), and lung (rats: chronic inflammation, etc. at 0.00075 mg/L) was found at the doses within the guidance value range for Category 1 (NTP TR377 (1990)). Therefore, it was classified in Category 1 (respiratory system).
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 96-hour LC50 = 0.22 mg/L for fish (Oncorhynchus mykiss) (AQUIRE, 2013).
11	Hazardous to the aquatic environment (Long-term)	Category 1	Warning	H410	P273 P391 P501	Reliable chronic toxicity data were not obtained. It was classified in Category 1 because it is not rapidly degradable (BIOWIN), and it was classified in Category 1 in acute toxicity.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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