Item | Information |
---|---|
CAS RN | 639-58-7 |
Chemical Name | Triphenyltin chloride |
Substance ID | 25B0040 |
Classification year (FY) | FY2013 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance by the Japanese Government (July, 2013) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
7 | Flammable solid | Classification not possible |
- |
- | - | No data available. |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of > 250 deg C (NITE Chemical Risk Information Platform (NITE-CHRIP) (Access on September 2013)). |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | From information on water solubility: 40 ppm (20 deg C) (HSDB (Access on September 2013)), it is recognized that it does not react vigorously with water. |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
14 | Oxidizing solids | Not applicable |
- |
- | - | It is an organic compound which does not contain fluorine or oxygen but contains chlorine, and because the chlorine is ionically bonded, it does not contribute to oxidization. |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 |
P301+P310
P264 P270 P321 P330 P405 P501 |
It was classified in Category 3 based on oral LD50 values for rats of 80 mg/kg (males) (EHC 15 (1980), HSDB (Access on September 2013)), 135 mg/kg (females) (EHC 15 (1980), HSDB (Access on September 2013)), and 190 mg/kg (HSDB (Access on September 2013)). |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 |
P302+P352
P332+P313 P362+P364 P264 P280 P321 |
This substance was classified in Category 2 because burns of the skin were observed in humans (HSDB (Access on September 2013)), and strong reactions in the skin were found in rats (RTECS (2004), the original article: NITS OTS0571949, HSDB (Access on September 2013)). |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 |
P305+P351+P338
P337+P313 P264 P280 |
This substance was classified in Category 2 because strong reactions were observed in an eye irritation test with rats (a Draize test) (RTECS (2004), the original article: NITS OTS0571949). |
4 | Respiratory sensitization | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a micronucleus test with mice (CICAD 13 (1999)) and negative in a chromosomal aberration test with Chinese hamsters (CICAD 13 (1999)). Furthermore, as the assessment result of triphenyltin compounds, it is concluded in CICAD 13 (1999) that triphenyltin does not present a genotoxic hazard. |
6 | Carcinogenicity | Classification not possible |
- |
- | - | There are no carcinogenicity data on this substance, but it is concluded that triphenyltin compounds including this substance were assessed to be not carcinogenic (CICAD 13 (1999), EHC 15 (1980)), and it is described in ACGIH that organic tin compounds are classified in A4 (Not Classifiable as a human carcinogen) (ACGIH (1995)). Therefore, it was classified as "Classification not possible." The category was changed according to the GHS classification guidance for the Japanese government. |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 |
P308+P313
P201 P202 P280 P405 P501 |
It was classified in Category 2 because implantation inhibition was observed in rats (CICAD 13 (1999)), and reproductive and developmental effects were found for triphenyltin compounds at the doses that caused maternal toxicity in experimental animals (CICAD 13 (1999)). |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, for triphenyltin hydroxide (CAS: 76-87-9), central nervous system symptoms such as emesis, tremor, and drowsiness were observed within the guidance value range for Category 1 after single oral administration to animals (CICAD 13 (1999)). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (immune system) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
It was classified in Category 1 (immune system) because, in 2-week or 4-week oral dose (feeding) tests with rats and mice, effects on the immune system such as atrophy of the thymus or spleen were observed at the doses (converted guidance value: 0.23-1.7 mg/kg/day) within the guidance value range for Category 1 (CICAD 13 (1999)), and it is described that triphenyltin compounds may affect the immune system, resulting in impaired function (CICAD 13 (1999)). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 |
Warning |
H400 |
P273
P391 P501 |
It was classified in Category 1 from 24-hour LC50 = 0.035 mg/L for crustacea (Daphnia magna) (ECETOC TR91, 2003). |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 |
Warning |
H410 |
P273
P391 P501 |
Reliable chronic toxicity data were not obtained. It was classified in Category 1 because it is not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1988)), and it was classified in Category 1 in acute toxicity. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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