NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	618-85-9
Chemical Name	3,5-Dinitrotoluene
Substance ID	25B0039
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not classified	- -	-	-	There is a chemical group associated with explosive properties (nitro group) in the molecule, and the calculated oxygen balance is -114, but data on the onset temperature and decomposition energy were not obtained. Because it is classified in Division 6.1 (UN3454) in UNRTDG, it is estimated that it does not correspond to the hazards of the highest precedence.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solid	Classification not possible	- -	-	-	No data available.
8	Self-reactive substances and mixtures	Type G	- -	-	-	There is a chemical group associated with explosive properties (nitro group) in the molecule, but because it is classified in Division 6.1 (UN3454) in UNRTDG, it is estimated that it is not classified as the hazards of the highest precedence, self-reactive substances and mixtures.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	- -	-	-	Because it is classified in Division 6.1 (UN3454) in UNRTDG, it is estimated that it is not classified as the hazards of the highest precedence, pyrophoric solids.
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Classification not possible	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the element other than carbon or hydrogen (N). However, the classification is not possible due to no data.
15	Organic peroxides	Not applicable	- -	-	-	There is no no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	There are reports on three oral LD50 values for rats (216 mg/kg (Environmental Risk Assessment for Chemical Substances vol. 5 (Ministry of the Environment, 2006)), 216 mg/kg (females) (DFGOT vol. 6 (1994)), and 309 mg/kg (males) (DFGOT vol. 6 (1994))). Two corresponded to Category 3, one corresponded to Category 4, and it was classified in Category 3 to which most data corresponded.
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. [Refer to the classification for this hazard class for dinitrotoluene (CAS: 25321-14-6).]
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. [Refer to the classification for this hazard class for dinitrotoluene (CAS: 25321-14-6).]
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. As for in vivo, it was negative in a dominant lethal test with mice (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), Environmental Risk Assessment for Chemical Substances vol. 5 (Ministry of the Environment, 2006), IARC (1996), DFGOT vol. 6 (1994)). As for in vitro, there are positive and negative data in bacterial reverse mutation tests (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), Environmental Risk Assessment for Chemical Substances vol. 5 (Ministry of the Environment, 2006), IARC (1996), DFGOT vol. 6 (1994), HSDB (Access on September 2013)), and it was negative in a gene mutation test (hprt) with cultured mammalian cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), Environmental Risk Assessment for Chemical Substances vol. 5 (Ministry of the Environment, 2006), IARC (1996)).
6	Carcinogenicity	Classification not possible	- -	-	-	This substance is classified in "Carc. Cat. 2; R45" in EU DSD classification and "Carc. 1B H350" in EU CLP classification, and these were information sources in List 3. On the other hand, it is classified in Group 3 in IARC (1996), which is the information source in List 1. Therefore, IARC (1996) was adopted based on the precedence of information sources, and it was classified as "Classification not possible." [Refer to the classification for this hazard class for dinitrotoluene (CAS: 25321-14-6).]
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. [Refer to the classification for this hazard class for dinitrotoluene (CAS: 25321-14-6).]
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	It was classified in Category 3 (narcotic effects) because it is described that effects on the nervous system: ataxia and respiratory depression were observed after oral administration to experimental animals, but these disappeared later (RTECS (2013), the original article: Harry V. (1980)).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. [Refer to the classification for this hazard class for dinitrotoluene (CAS: 25321-14-6).]
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 3	- -	H402	P273 P501	It was classified in Category 3 from 96-hour LC50 = 22 mg/L for fish (Pimephales promelas) (Initial Risk Assessment (NITE, CERI, NEDO, 2005); Environmental Risk Assessment for Chemical Substances Vol. 5 (Ministry of the Environment, 2006)).
11	Hazardous to the aquatic environment (Long-term)	Category 3	- -	H412	P273 P501	Reliable chronic toxicity data were not obtained. It was classified in Category 3 because it is not rapidly degradable (BIOWIN), and it was classified in Category 3 in acute toxicity.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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