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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	140-11-4
Chemical Name	Benzyl acetate
Substance ID	25B0036
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P403+P235 P210 P280 P501	It was classified in Category 4 from a flash point of 90 deg C (closed cup) (HSDB (Access on September 2013)).
7	Flammable solid	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 460 deg C (HSDB (Access on September 2013)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	It was classified as "Not classified" (Category 5 in UN GHS classification) based on LD50 values for rats of 2,490 mg/kg (ACGIH (7th, 2001), PATTY (6th, 2012)) and 3,690 mg/kg (ACGIH (7th, 2001)). Besides, data in PATTY (6th, 2012) obtained in this investigation were added, and the classification was changed from Category 5 to "Not classified" according to the Classification JIS.
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" based on an LD50 value of > 5,000 mg/kg for rabbits (PATTY (6th, 2012), IUCLID (2000)).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	It was classified in Category 2 because it is described that it is irritating to the skin, eye, and respiratory tract (HSDB (Access on September 2013)), and it was moderately irritating in rabbits and humans in a GLP test according to the EC guideline (IUCLID (2000)).
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	It is described that it causes irritation to the eye (IARC (1986)), and it is irritating to the eye, and blepharospasm was observed in an eye irritation test with rabbits (HSDB (Access on September 2013)). Because there are no descriptions of reversibility, it was classified in Category 2 based on the above information.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	It is described in ACGIH (7th, 2001) that no reaction was observed at an 8% concentration of this substance in a sensitization test in volunteers, and it is described that it was negative in a Buehler test and a maximization test with guinea pigs and negative in a patch test in humans (IUCLID (2000)), but there is a description that sufficient data on sensitization were not available (ACGIH (7th, 2001)). Therefore, it was classified as "Classification not possible."
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in all of micronucleus tests with bone marrow cells and peripheral blood erythrocytes of mice (IARC (1999), JECFA TRS 909 (2002), NTP DB (Access on June 2013), IUCLID (2000)), a chromosomal aberration test with mouse bone marrow cells (IARC (1999), JECFA TRS 909 (2002), NTP DB (Access on June 2013)), a sister chromatid exchange test with mouse bone marrow cells (IARC (1999), JECFA TRS 909 (2002), NTP DB (Access on June 2013), IUCLID (2000)), an unscheduled DNA synthesis test with rat hepatocytes, and a DNA strand-break test with rat pancreas (IARC (1999), JECFA TRS 909 (2002)). As for in vitro, there are positive data in a mouse lymphoma test with cultured mammalian cells (IARC (1999), JECFA TRS 909 (2002), NTP DB (Access on June 2013)), but it was negative in a bacterial reverse mutation test (IARC (1999), ACGIH (7th, 2001), JECFA TRS 909 (2002), NTP DB (Access on June 2013), IUCLID (2000)) and a chromosomal aberration test with cultured mammalian cells (IARC (1999), JECFA TRS 909 (2002), NTP DB (Access on June 2013)).
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it is classified in A4 in ACGIH (1994) and Group 3 in IARC 71 (1999). The category was changed according to the GHS classification guidance for the Japanese government.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, as for developmental toxicity, in a developmental toxicity test with rats in the oral (gavage) route, maternal animals showed slightly reduced weight gain, and a decrease in fetal body weights was observed. No malformations were seen, but internal and skeletal variations were found, which were thought to be due to maternal toxicity and lower fetal body weights (JECFA FAS 868 (1996)). Furthermore, it is reported that in 13-week oral administration toxicity tests with rats or mice, no effects on the sperm and genetic organs were seen in males, and extension of the estrous cycle was observed in female mice, but this was associated with lower body weights (JECFA FAS 868 (1996), NTP TR431 (1993)), and it is described in PATTY (6th, 2012) that this substance was not considered to be a reproductive toxin because no compound-related effects on the genetic organs were found in subchronic toxicity tests with rats and mice. However, it was classified as "Classification not possible" because no sufficient tests on fertility effects were conducted.
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs), Category 3 (narcotic effects)	Danger Warning	H370 H336	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	It was classified in Category 1 (respiratory organs), Category 3 (narcotic effects) because it is described that it produces respiratory tract irritation and narcotic effects in humans (NTP TR250 (1986), ACGIH (7th, 2001)), and lung hyperemia, pulmonary edema (ACGIH (7th, 2001)), and central nervous system depression (NTP TR431 (1993)) were observed in mice after exposure to vapour (1.3 mg/L) within the guidance value range for Category 1.
9	Specific target organ toxicity - Repeated exposure	Category 1 (kidney), Category 2 (nasal cavity)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	It was classified in Category 1 (kidney) because it is described that continued inhalation exposure to this substance results in kidney damage in humans (NTP TR250 (1986)). On the other hand, as for experimental animals, no toxicity effects were seen even after exposure to the doses above the range for Category 2 in a 2-year diet administration test with rats (NTP TR431 (1993)), but it is described that nasal lesions (atrophy and degeneration of the olfactory epithelium, hyperplasia of the nasal submucosal glands, pigmentation of the nasal mucosal epithelium) were observed at the dose (35-40 mg/kg/day) within the guidance value range for Category 2 in a 2-year diet administration test with mice (NTP TR431 (1993)). It was classified in Category 2 (nasal cavity) from the viewpoint of assessing adverse effects while standing on the safe side.
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 2	- -	H401	P273 P501	It was classified in Category 2 from 96-hour LC50 = 4 mg/L for fish (Oryzias latipes) (ECETOC TR91, 2003).
11	Hazardous to the aquatic environment (Long-term)	Category 3	- -	H412	P273 P501	It was classified in Category 3 due to rapid degradability (a 28-day degradation rate by BOD = 95% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1989)), and 28-day NOEC = 0.92 mg/L for fish (Oryzias latipes) (ECETOC TR91, 2003).
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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