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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	124-40-3
Chemical Name	Dimethylamine
Substance ID	25B0033
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	Gas (GHS definition)
2	Flammable gases (including chemically unstable gases)	Category 1	Danger	H220	P210 P377 P381 P403	It was classified in Category 1 from explosion limit (2.8-14.4 (ICSC (2003))). Besides, it is classified in Division 2.1 (UN1032) in UNRTDG.
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not classified	- -	-	-	It is a flammable gas classified in Division 2.1 in UNRTDG.
5	Gases under pressure	Liquefied gas	Warning	H280	P410+P403	From a critical temperature (437.22 K (HSDB (Access on September 2013))) above 65 deg C, it was classified as liquefied gas (low pressure liquefied gas).
6	Flammable liquids	Not applicable	- -	-	-	Gas (GHS definition)
7	Flammable solid	Not applicable	- -	-	-	Gas (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	Gas (GHS definition)
9	Pyrophoric liquids	Not applicable	- -	-	-	Gas (GHS definition)
10	Pyrophoric solids	Not applicable	- -	-	-	Gas (GHS definition)
11	Self-heating substances and mixtures	Not applicable	- -	-	-	Gas (GHS definition)
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	Gas (GHS definition)
13	Oxidizing liquids	Not applicable	- -	-	-	Gas (GHS definition)
14	Oxidizing solids	Not applicable	- -	-	-	Gas (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Gas (GHS definition)
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to gas substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not applicable	- -	-	-	Gas (GHS definition) Besides, there are reports on an LD50 value for rats of 698 mg/kg (ACGIH (7th, 2001), DFGOT vol. 7 (1996), PATTY (6th, 2012)) in a test on an aqueous solution of this substance.
1	Acute toxicity (Dermal)	Not applicable	- -	-	-	Gas (GHS definition)
1	Acute toxicity (Inhalation: Gases)	Category 4	Warning	H332	P304+P340 P261 P271 P312	It was classified in Category 4 based on an LC50 value (4 hours) of 4,700 mL/m3 for rats (ACGIH (7th, 2001), DFGOT vol. 7 (1996)).
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Gas (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Not applicable	- -	-	-	Gas (GHS definition)
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	It is described that erythema, swelling, and finally ulceration of the skin were observed in a test in which aqueous solutions of this substance were applied to the rabbit skin (DFGOT vol. 7 (1996), ACGIH (7th, 2001)) and that sharply defined hyperemia with subsequent tissue necrosis was found in a test in which a tip of the mouse tail was dipped into a solution of this substance for 2 hours (DFGOT vol. 7 (1996), ACGIH (7th, 2001)). Furthermore, it is classified in "C; R34" in EU DSD classification and "Skin Corr. 1B H314" in EU CLP classification. It was classified in Category 1 based on the above information. Besides, sub-categorization was not conducted because the details are unknown.
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	In an eye irritation test with rabbits, the application of a 1% solution of this substance caused conjunctivitis, conjunctival edema, keratitis, and clouding of the cornea, and the application of a 5% solution of this substance caused hemorrhage in the conjunctiva, corneal edema, opacities, and vascularization, which persisted for 28 days (DFGOT vol. 7 (1996), ACGIH (7th, 2001)). And as for higher-concentration solutions of this substance (concentration: unknown), the cornea turned translucent and whitish-blue a few seconds after the application (DFGOT vol. 7 (1996), ACGIH (7th, 2001)). Furthermore, it is classified in "C; R34" in EU DSD classification and "Skin Corr. 1B H319" in EU CLP classification. It was classified in Category 1 based on the above information.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	It was classified in Category 1 because it is described that it was positive (positive rate: 100%) in a maximization test with guinea pigs (occlusive application) (DFGOT vol. 7 (1996)) and that this substance was a skin sensitizer (ACGIH (7th, 2001)).
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a chromosomal aberration test with rat bone marrow cells (DFGOT vol. 7 (1996), IUCLID (2000)). As for in vitro, all bacterial reverse mutation tests were negative except for one weakly positive result in the bacterial strain not commonly used (ACGIH (7th, 2001), DFGOT vol. 7 (1996), NTP DB (Access on June 2013), IUCLID (2000)), and it was negative in a gene mutation test (ACGIH (7th, 2001), DFGOT vol. 7 (1996), IUCLID (2000)) and a chromosomal aberration test (DFGOT vol. 7 (1996), IUCLID (2000)) with cultured mammalian cells.
6	Carcinogenicity	Classification not possible	- -	-	-	This substance was classified as "Classification not possible" because ACGIH classified it in A4 (ACGIH (1995)). The category was changed according to the revised GHS classification guidance for the Japanese government.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs), Category 3 (narcotic effects)	Danger Warning	H370 H336	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	In an inhalation exposure test with rats, tissue damage in the mucosa of the respiratory organs was observed at exposure concentrations of 600 ppm or above (PATTY (6th, 2012)), RD50 values (concentration producing a 50% reduction in respiration rate) were determined in short-term inhalation exposure in rats and mice (DFGOT vol. 7 (1996)), and it is irritating to the respiratory tract. Therefore, it was classified in Category 1 (respiratory organs). Furthermore, it was classified in Category 3 (narcotic effects) because it is described that disturbances of motor coordination and sluggishness were found in an oral administration test with rats, mice, rabbits, and guinea pigs (ACGIH (7th, 2001)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	It was classified in Category 1 (respiratory organs) because it is described that in a 2-year inhalation exposure test with rats and mice, inflammatory, degenerative, and hyperplastic lesions in the nasal mucosa were observed in the exposure group of 50 ppm, the upper limit of the guidance value range for Category 1 (ACGIH (7th, 2001), DFGOT vol. 7 (1996), PATTY (6th, 2012)).
10	Aspiration hazard	Not applicable	- -	-	-	Gas (GHS definition)

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 2	- -	H401	P273 P501	It was classified in Category 2 from 96-hour EC50 = 6.2 mg/L for algae (Pseudokirchneriella subcapitata) (SIAP, Conclusions Agreed in CoCAM 4, 2013).
11	Hazardous to the aquatic environment (Long-term)	Category 3	- -	H412	P273 P501	If chronic toxicity data are used, then it is classified in Category 3 due to rapid degradability (a degradation rate by BOD (NH3): 88% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1975)), and 50-day NOEC = 0.6 mg/L for fish (Oncorhynchus mykiss) (SIAP, Conclusions Agreed in CoCAM 4, 2013). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, there are data: 96-hour EC50 = 6.2 mg/L for algae (Pseudokirchneriella subcapitata) (SIAP, Conclusions Agreed in CoCAM 4, 2013). However, it is rapidly degradable (a degradation rate by BOD (NH3): 88% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1975)), and low bioaccumulation is estimated (log Kow = -0.38 (HSDB, 2013)). Therefore, it is classified as "Not classified." By drawing a comparison between the above results, it was classified in Category 3.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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