NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	116-14-3
Chemical Name	Tetrafluoroethylene
Substance ID	25B0029
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	Gas (GHS definition)
2	Flammable gases (including chemically unstable gases)	Category 1, Category B	Danger	H220 H231	P210 P377 P381 P403 P202	From explosion limit (10.0-50.0% (NFPA (13th,2002))), it was classified in Category 1. Besides, it is classified in Division 2.1 (UN1081) in UNRTDG. It was classified in Category B from the judgment result in UNRTDG Test Manual (2011).
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not classified	- -	-	-	It is a flammable gas classified in Division 2.1 (UN1081) in UNRTDG.
5	Gases under pressure	Liquefied gas	Warning	H280	P410+P403	From a critical temperature (33.3 deg C (HSDB (Access on July 2013))) between -50 deg C and +65 deg C, it was classified as liquefied gas.
6	Flammable liquids	Not applicable	- -	-	-	Gas (GHS definition)
7	Flammable solid	Not applicable	- -	-	-	Gas (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	Gas (GHS definition)
9	Pyrophoric liquids	Not applicable	- -	-	-	Gas (GHS definition)
10	Pyrophoric solids	Not applicable	- -	-	-	Gas (GHS definition)
11	Self-heating substances and mixtures	Not applicable	- -	-	-	Gas (GHS definition)
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	Gas (GHS definition)
13	Oxidizing liquids	Not applicable	- -	-	-	Gas (GHS definition)
14	Oxidizing solids	Not applicable	- -	-	-	Gas (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Gas (GHS definition)
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to gas substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not applicable	- -	-	-	Gas (GHS definition)
1	Acute toxicity (Dermal)	Not applicable	- -	-	-	Gas (GHS definition)
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	It was classified as "Not classified" based on LC50 (4 hours) of 25,000 ppm (ACGIH (7th, 2001)), 31,000 ppm (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)), 40,000 ppm (ECETOC JACC (2003)), and 45,000 ppm (ACGIH (7th, 2001)) in inhalation exposure tests (gas) with rats.
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Gas (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Not applicable	- -	-	-	Gas (GHS definition)
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	It was classified in Category 2B from the description of exposure in humans in HSDB (Access on July 2013) that contact with eyes causes slight irritation.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a micronucleus test with mouse peripheral blood erythrocytes (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007), ACGIH (7th, 2001), IARC 71 (1999), NTP DB (Access on July 2013)). Furthermore, as for in vitro, it was negative in a bacterial reverse mutation test and a gene mutation test and a chromosomal aberration test with cultured mammalian cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007), ACGIH (7th, 2001), IARC 71 (1999), IUCLID (2000)).
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	It was classified in Category 2 because it is classified in 2B in IARC 71 (1999), R in NTP (2011), and 2B in the Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2012).
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 2 (kidney, liver)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	As for experimental animals, it is described that increases in blood urea nitrogen, urine volume, urinary excretion of glucose, and alkaline phosphatase and gamma-glutamyl transpeptidase activities were observed after inhalation exposure to 4,000 and 6,000 ppm in rats (ACGIH (7th, 2001), Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)), therefore the kidney and liver were judged to be the target organs. Besides, these effects in experimental animals were found within the guidance value range corresponding to Category 2. From the above, it was classified in Category 2 (kidney, liver).
9	Specific target organ toxicity - Repeated exposure	Category 2 (kidney, liver)	Warning	H373	P260 P314 P501	As for experimental animals, it is described that in a 2-year inhalation exposure test with rats, males showed renal tubular degeneration and cystic degeneration in the liver after exposure to 156 ppm (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007), ACGIH (7th, 2001)), therefore the kidney and liver were considered to be the target organs. Besides, these effects in experimental animals were observed within the guidance value range corresponding to Category 2. From the above, it was classified in Category 2 (kidney, liver).
10	Aspiration hazard	Not applicable	- -	-	-	Gas (GHS definition)

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Classification not possible	- -	-	-	No data available.
11	Hazardous to the aquatic environment (Long-term)	Classification not possible	- -	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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