NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	111-40-0
Chemical Name	N-(2-Aminoethyl)-1,2-ethanediamine; Diethylenetriamine
Substance ID	25B0028
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Not classified	- -	-	-	A flash point is 97 deg C (closed cup) (ICSC (1996)) above 93 deg C.
7	Flammable solid	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 358 deg C (ICSC (1996)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	It was classified in Category 4 based on LD50 values of 1,080 mg/kg (ACGIH (7th, 2001), Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), PATTY (6th, 2012)), about 1,140 mg/kg, 1,539 mg/kg, about 1,800 mg/kg, and 1,950 mg/kg (SIDS (2002)) in oral administration tests with rats.
1	Acute toxicity (Dermal)	Category 4	Warning	H312	P302+P352 P362+P364 P280 P312 P321 P501	LD50 values in dermal administration tests with rabbits are about 672 mg/kg, 1,040 mg/kg (SIDS (2002)), and 1,090 mg/kg (ACGIH (7th, 2001), Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013)), one corresponds to Category 3, and two correspond to Category 4. According to the revised GHS classification guidance for the Japanese government, it was classified in Category 4 to which most data corresponded.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, the result in the Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), the rationale for the previous classification, was not adopted because it was LDLo.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	Strong corrosivity or corrosivity is described as health effects in humans (Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)) and the results of skin irritation tests with rabbits (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), SIDS (2002)). Furthermore, this substance is classified in "C; R34" in EU DSD classification and "Skin Corr. 1B H314" in EU CLP classification. It was classified in Category 1 based on the above information.
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Strong irritation, high corrosivity, or loss of vision is described as data on health effects in humans (Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), ACGIH (7th, 2001)) and the results of administering the undiluted substance in eye irritation tests with rabbits (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), SIDS (2002)). Furthermore, this substance is a skin irritant and is classified in "C; R34" EU DSD classification and "Skin Corr. 1B H314" in EU CLP classification. It was classified in Category 1 based on the above information.
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	As data on health effects in humans, it is described that asthma-like allergic reactions in the respiratory tract from occupational exposure are reported (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), SIDS (2002), ACGIH (7th, 2001)), therefore it was considered to cause respiratory sensitization, and it was classified in Category 1.
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	It was considered to be sensitizing to the skin because of a positive result in a maximization test with guinea pigs (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), SIDS (2002)), reports that positive results were observed in patch tests in workers handling this substance, etc. (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), SIDS (2002), ACGIH (7th, 2001)). Furthermore, this substance is classified in "R43" in EU DSD classification and "Skin Sens. 1 H317" in EU CLP classification. It was classified in Category 1 based on the above information.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a micronucleus test with mouse bone marrow cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), SIDS (2002)). Furthermore, as for in vitro, it was negative in a bacterial reverse mutation test and a gene mutation test and a chromosomal aberration test with cultured mammalian cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), SIDS (2002)).
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not classified by other organizations, and there is toxicity information but no reliable information.
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	It is described in the Initial Risk Assessment Report (NITE, CERI, NEDO, 2005) and Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013) that in a reproduction/developmental toxicity screening test with rats (OECD TG 421), reproductive and developmental effects (extension of a gestation period, increased embryonic/fetal death, etc.) were observed at the dose where no other toxicity signs were seen in parent animals. Therefore, it was classified in Category 1B according to the GHS classification guidance for the Japanese government.
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data.
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 3	- -	H402	P273 P501	From 48-hour EC50 = 16 mg/L for crustacea (Daphnia magna) (SIDS, 2002), it was classified in Category 3.
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	If chronic toxicity data are used, then it is classified as "Not classified" due to being not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1982)), and 21-day NOEC = 5.6 mg/L for crustacea (Daphnia magna) (SIDS, 2002). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to being not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1982)), and 96-hour LC50 = 248 mg/L for fish (Leuciscus idus) (SIDS, 2002). From the above results, it was classified as "Not classified."
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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