GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 110-82-7
Chemical Name Cyclohexane
Substance ID 25B0027
Classification year (FY) FY2013
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Category 2


Danger
H225 P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
From a flash point of -18 deg C (closed cup) and a boiling point of 81 deg C (ICSC (2011)), it was classified in Category 2. Besides, it is classified in Class 3, PG II (UN1145) in UNRTDG.
7 Flammable solid Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 260 deg C (ICSC (2011)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Organic compounds containing no oxygen, fluorine or chlorine.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule.
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- - It was classified as "Not classified" from 5 LD50 values for rats of > 5,000 mg/kg, 6,240 mg/kg, 12,870 mg/kg, 29,800 mg/kg, and 30,420 mg/kg (EU-RAR (2004)).
1 Acute toxicity (Dermal) Not classified
-
-
- - It was classified as "Not classified" based on the description that no death was observed at 2,000 mg/kg in rabbits (EU-RAR (2004)).
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not classified
-
-
- - It was classified as "Not classified" based on 4-hour exposure LC50 of > 9,500 ppmV (32.88 mg/L) for rats (EU-RAR (2004)). Besides, because the concentration of test substance was lower than 90% [113,169 ppmV (132.4 mg/L) ] of the saturated vapour pressure concentration (125,743 ppm), a reference value in the unit of ppmV was applied as a vapour without a mist.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Category 2


Warning
H315 P302+P352
P332+P313
P362+P364
P264
P280
P321
It is described that it was irritating to the skin in rabbits and humans (DFGOT vol. 13 (1999), EU-RAR (2004), ACGIH (7th, 2002), ICSC (J) (1994)). It is described that repeated administration to rabbits produced cracked skin and bleeding, but these disappeared one week after the administration (DFGOT vol. 13 (1999)), and the 1-hour application of the undiluted substance to humans produced erythema and wheal formation (EU-RAR (2004)), which are also thought to be reversible disorder. It was classified in Category 2 from the above data.
3 Serious eye damage/eye irritation Category 2


Warning
H319 P305+P351+P338
P337+P313
P264
P280
It is described that corneal opacity, iritis, and conjunctival redness/chemosis were observed in rabbits, and all of these were reversible (EU-RAR (2004)), and that it was irritating to the eye in animals and humans (PATTY (6th, 2012), EU-RAR (2004), ICSC (J) (1994), HSDB (Access on July 2013)). Therefore, it was classified in Category 2.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a chromosomal aberration test with rat bone marrow cells (EU-RAR (2004), DFGOT vol. 13 (1999), IRIS (2003), PATTY (6th, 2012), IUCLID (2000)). Furthermore, as for in vitro, it was negative in a bacterial reverse mutation test (EU-RAR (2004), DFGOT vol. 13 (1999), IRIS (2003), PATTY (6th, 2012), IUCLID (2000), ACGIH (7th, 2002)) and a mouse lymphoma test with cultured mammalian cells (EU-RAR (2004), DFGOT vol. 13 (1999), IRIS (2003), PATTY (6th, 2012), IUCLID (2000)).
6 Carcinogenicity Classification not possible
-
-
- - It was classified as "Classification not possible" because EPA classified it in I (IRIS (2003)). The category was changed according to the revised GHS classification guidance for the Japanese government.
7 Reproductive toxicity Not classified
-
-
- - In a two-generation test with rats by inhalation exposure, even at the dose which produced severe general toxicity effects (reduced weight gain, decreased food consumption) in parent animals, no fertility effects were seen in parent animals, and only minimum effects (decreased pup weights) were observed in offspring (EU-RAR (2004), ACGIH (7th, 2002)). And in a developmental toxicity test in which pregnant rats were exposed by inhalation, no effects occurred in fetuses even at the doses where maternal toxicity (reduced weight gain, decreased food consumption, diminished response to a sound stimulus) was found (EU-RAR (2004), ACGIH (7th, 2002)). From the above, it was classified as "Not classified" according to the GHS classification guidance for the Japanese government.
8 Specific target organ toxicity - Single exposure Category 2 (cardiovascular system), Category 3 (respiratory tract irritation, narcotic effects)



Warning
H371
H335
H336
P308+P311
P260
P264
P270
P405
P501
P304+P340
P403+P233
P261
P271
P312
Signs of central nervous system depression from inhalation exposure are reported in many kinds of animal species (ACGIH (7th, 2002)), and it is thought to cause narcotic effects, but exposure concentrations are unclear. It was classified in Category 2 (vascular system) because it is described that after oral administration to rabbits, the vascular injury was observed at the dose within the guidance value range for Category 2 (ACGIH (7th, 2002)). Furthermore, It was classified in Category 3 (respiratory tract irritation, narcotic effects) based on the description that it was irritating to the respiratory tract in humans (ACGIH (7th, 2002)).
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - There are no descriptions that the toxicity of this substance occurred in humans (ACGIH (7th, 2002), EU-RAR (2004), PATTY (6th, 2012)), and in experimental animals, no toxicity was observed at the doses within the guidance value range for Category 2 in 10-14-week inhalation toxicity tests (mice, rats, rabbits) (minimum concentration that produced toxicity: 786 ppm (converted guidance value concentration: 2.08 mg/L/6 hours)) (ACGIH (7th, 2002), EU-RAR (2004), PATTY (6th, 2012)). Therefore, it falls under "Not classified" in the inhalation route, but there is no toxicity information on the other routes, Therefore, the classification is not possible due to lack of data.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, it may be fatal when swallowed this substance (liquid), and it enters the airway by aspiration (ICSC (J) (1994)). The category was changed according to the revised GHS classification guidance for the Japanese government.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1


Warning
H400 P273
P391
P501
From 48-hour EC50 = 0.9 mg/L for crustacea (Daphnia magna) (EU-RAR, 2004), it was classified in Category 1.
11 Hazardous to the aquatic environment (Long-term) Category 3
-
-
H412 P273
P501
If chronic toxicity data are used, then it is classified in Category 3 due to rapid degradability (a 28-day degradation rate by OECD Test Guideline 301F: 77% (EU-RAR, 2004)), and 72-hour NOEC = 0.94 mg/L for algae (Pseudokircheneriella subcapitata) (EU-RAR, 2004).
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, there are data: 48-hour EC50 = 0.9 mg/L for crustacea (Daphnia magna) (EU-RAR, 2004). However, it is rapidly degradable (a 28-day degradation rate by OECD Test Guideline 301F: 77% (EU-RAR, 2004)), and low bioconcentration is estimated (BCF = 31-129 (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1984)). Therefore, it is classified as "Not classified."
By drawing a comparison between the above results, it was classified in Category 3.
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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