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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	102-71-6
Chemical Name	Triethanolamine
Substance ID	25B0023
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Not classified	- -	-	-	A flash point is 179 deg C (closed cup) (HSDB (Access on July 2013)) above 93 deg C.
7	Flammable solid	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 324 deg C (HSDB (Access on July 2013)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	It was classified as "Not classified" from LD50 values for rats of 8,680 mg/kg, 9,110 mg/kg (ACGIH (7th, 2001), PATTY (6th, 2012)), 8,000 mg/kg (PATTY (6th, 2012)), 8,000-9,000 mg/kg, and 4,200-11,300 mg/kg (NTP TR 518 (2004), SIDS (2001)).
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" based on a dermal LD50 value of > 2,000 mg/kg for rabbits (SIDS (2001)) and a description that no death was observed in a test by 24-hour dermal application of 2 g/kg to rabbit skin (NTP TR 518 (2004)).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	It was classified in Category 2 because it is described in ACGIH (7th, 2001), SIDS (2001), IARC 77 (2000), and NTP TR 518 (2004) that skin irritation was observed after high-concentration exposure or repeated exposure in humans.
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	It was classified in Category 2A because it is described in ACGIH (7th, 2001), PATTY (6th, 2012), and NTP TR 518 (2004) that in an eye irritation test with rabbits, irritation was observed, and it was fully reversible after 14 days.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	It was classified in Category 1 because it is described in ACGIH (7th, 2001), IARC 77 (2000), and NTP TR 518 (2004) that allergic contact dermatitis is reported in humans.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, there is a negative result in a micronucleus test with mouse peripheral blood (IARC 77 (2000), NTP TR 518 (2004), NTP DB (Access on June 2013)). Furthermore, as for in vitro, it was negative in a bacterial reverse mutation test and a chromosomal aberration test with cultured mammalian cells (SIDS (2001), IARC 77 (2000), ACGIH (7th, 2001), NTP DB (Access on June 2013)).
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it is classified in Group 3 in IARC 77 (2000). The category was changed according to the revised GHS classification guidance for the Japanese government.
7	Reproductive toxicity	Classification not possible	- -	-	-	It is described in IARC 77 (2000) that in tests with rats and mice by 13-week dermal administration at or above 2,000 mg/kg, no effects were observed in sperm examination and the estrous cycle of females, and it is described in NTP TR 518 (2004) that no effects were found in fetuses/offspring in a test in which 1,125 mg/kg was orally administered to mice during gestation. And it is described in IARC 77 (2000) that no effects on fertility and development of offspring were seen in tests by dermal administration to rats at 500 mg/kg and mice at 2,000 mg/kg before mating until the end of a lactation period. From the above, it corresponds to "Not classified" in the dermal route, but because there are no breeding test data in the oral route, it was classified as "Classification not possible" due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	It was classified in Category 3 (respiratory tract irritation) because it is described in NTP TR 518 (2004) that vapours are irritating to the nose in humans.
9	Specific target organ toxicity - Repeated exposure	Not classified	- -	-	-	It is described in IARC (2000), ACGIH (7th, 2001), PATTY (6th, 2012) that in tests by dermal exposure (mice: 13 weeks or 2 years), oral exposure (rats, mice, guinea pigs: 12-13 weeks or 2 years), or inhalation exposure (rats, mice: 16 days), severe toxicity effects were not observed even after exposure at the doses (dermal (200-2,000 mg/kg/day), oral (200-3,000 mg/kg/day), inhalation (0.36 mg/L/6 hours) above the guidance value range for Category 2). Therefore, it was classified as "Not classified."
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Not classified	- -	-	-	it was classified as "Not classified" from 96-hour EC50 = 169 mg/L for algae (Desmodesmus subspicatus), 24-hour EC50 = 1386 mg/L for crustacea (Daphnia magna), and 96-hour LC50 = 11800 mg/L for fish (Pimephales promelas) (all SIDS, 2001).
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	If chronic toxicity data are used, then it is classified as "Not classified" due to 21-day NOEC = 16 mg/L for crustacea (Daphnia magna) (SIDS, 2001) although it is not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1978)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" because it corresponds to "Not classified" in acute toxicity for all of algae, crustacea, and fish, and it is not water-insoluble (miscible in water, HSDB, 2013). From the above results, it was classified as "Not classified."
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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