GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 94-36-0
Chemical Name Dibenzoyl peroxide
Substance ID 25B0022
Classification year (FY) FY2013
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Classification not possible
-
-
- - There is a chemical group associated with explosive properties present in the molecule. However, it is classified in Division 5.2 (UN3102) and the higher precedence Class 1 in UNRTDG.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Solid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Solid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Solid (GHS definition)
6 Flammable liquids Not applicable
-
-
- - Solid (GHS definition)
7 Flammable solid Classification not possible
-
-
- - No data available.
8 Self-reactive substances and mixtures Not classified
-
-
- - It is classified as organic peroxides.
9 Pyrophoric liquids Not applicable
-
-
- - Solid (GHS definition)
10 Pyrophoric solids Classification not possible
-
-
- - No data available.
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to solid (melting point <= 140 deg C) substances are not available (melting point 103-106 deg C (HSDB (Access on July 2013))).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Solid (GHS definition)
14 Oxidizing solids Classification not possible
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the element other than carbon or hydrogen (O). However, the classification is not possible due to no data.
15 Organic peroxides Type B



Danger
H241 P411+P235
P210
P220
P234
P280
P410
P420
P501
It was classified in Type B because it is classified in Division 5.2 (UN3102) in UNRTDG.
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- - It was classified as "Not classified" based on LD50 of > 5,000 mg/kg for rats (SIDS (2004)).
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Not classified
-
-
- - It was classified as "Not classified" based on LC0 of > 24.3 mg/L (converted value: 19.0 mg/L) for rats (SIDS (2004)).
2 Skin corrosion/irritation Not classified
-
-
- - Data are showing that it is slightly or not irritating to the skin, and it is concluded that it was slightly irritating to the skin (SIDS (2004)). Therefore, this substance was considered to be minimally or slightly irritating to the skin, and it was classified as "Not classified" in the Classification JIS (Category 3 in UN GHS classification). "Not classified" in the Classification JIS (Category 3 in UN GHS classification) was specified according to the revised GHS classification guidance for the Japanese government.
3 Serious eye damage/eye irritation Category 2


Warning
H319 P305+P351+P338
P337+P313
P264
P280
Irritation was observed at 24, 48, 72 hours after application to the eyes of rabbits (SIDS (2004)), and the grade of irritation depended on the test or test method. Furthermore, this substance is classified in "Xi; R36" in EU DSD classification and "Eye Irrit. 2 H319" in EU CLP classification. It was classified in Category 2 based on the above information. Besides, the classification was changed to Category 2 because the information on sub-categorization could not be obtained (the information that irritation in a Draize test with rabbits or human findings is mild and disappear within seven days).
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Category 1


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501
Skin sensitization was confirmed in the result of a maximization test in humans and epidemiological studies in occupational exposure (SIDS (2004)). It is classified in occupational skin sensitizers Group 2 in the Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2012), and it is listed as a skin sensitizer by the Special Committee of the Japanese Society of Occupational and Environmental Allergy (2004). Furthermore, this substance is classified in "R43" in EU DSD classification and "Skin Sens. 1 H317" in EU CLP classification. It was classified in Category 1 based on the above information.
5 Germ cell mutagenicity Classification not possible
-
-
- - It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a dominant lethal test with mice (SIDS (2004), IARC 71 (1999), JECFA (2006)) and a micronucleus test with mouse erythrocytes (SIDS (2004)). Furthermore, as for in vitro, it was negative in a bacterial reverse mutation test (SIDS (2004), JECFA (2006), NTP DB (Access on June 2013)) and a chromosomal aberration test with cultured mammalian cells (SIDS (2004), JECFA (2006), IARC 71 (1999)).
6 Carcinogenicity Classification not possible
-
-
- - It was classified as "Classification not possible" because it is classified in Group 3 in IARC (1999) and A4 in ACGIH (7th, 2001). The category was changed according to the revised GHS classification guidance for the Japanese government, and information was added.
7 Reproductive toxicity Classification not possible
-
-
- - It is described that in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats by oral administration (OECD TG 422), paternal animals showed decreased weights of the genetic organs and slight testis degeneration, but there were no fertility effects (mating, gestation), and minimum developmental effects (increased incidence of runts, decreased weight gain) were observed in offspring (SIDS (2004)). However, because it was impossible to classify it as "Not classified" from the results of the screening test, it was classified as "Classification not possible" due to lack of data.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation)


Warning
H335 P304+P340
P403+P233
P261
P271
P312
P405
P501
It was classified in Category 3 (respiratory tract irritation) because it is described that there was irritation of the nose and throat in humans (ACGIH (7th, 2001)).
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - It corresponds to "Not classified" in the oral route rats because effects on the reproductive organs of male and female were observed at the dose (1,000 mg/kg/day) above the guidance value range for Category 2 in a gavage administration test (OECD TG 422) (SIDS (2004)). However, because of no data on the other routes, it was classified as "Classification not possible" due to lack of data.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1


Warning
H400 P273
P391
P501
From 48-hour EC50 = 0.07 mg/L for crustacea (Daphnia magna) (SIDS, 2004), it was classified in Category 1.
11 Hazardous to the aquatic environment (Long-term) Not classified
-
-
- - Reliable chronic toxicity data were not obtained. It was classified in Category 1 in acute toxicity. However, it is rapidly degradable (a 28-day degradation rate by BOD = 84% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1981)), and low bioconcentration is estimated (LogPow = 3.46 (HSDB, 2013)). Therefore, it was classified as "Not classified."
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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