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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	75-38-7
Chemical Name	Vinylidene dibromide
Substance ID	25B0019
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	Gas (GHS definition)
2	Flammable gases (including chemically unstable gases)	Category 1	Danger	H220	P210 P377 P381 P403	From explosion limit (5.5-21.3% (ICSC (1997))), it was classified in Category 1. Besides, it is classified in Division 2.1 (UN1959) in UNRTDG. There is a group that indicates chemical instability, but information on test results was not obtained.
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not classified	- -	-	-	It is a flammable gas classified in Division 2.1 in UNRTDG.
5	Gases under pressure	High pressure liquefied gas	Warning	H280	P410+P403	From a critical temperature (29.75 deg C (HSDB (Access on July 2013))) between -50 deg C and +65 deg C, it was classfied as liquefied gas (high pressure liquefied gas)
6	Flammable liquids	Not applicable	- -	-	-	Gas (GHS definition)
7	Flammable solid	Not applicable	- -	-	-	Gas (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	Gas (GHS definition)
9	Pyrophoric liquids	Not applicable	- -	-	-	Gas (GHS definition)
10	Pyrophoric solids	Not applicable	- -	-	-	Gas (GHS definition)
11	Self-heating substances and mixtures	Not applicable	- -	-	-	Gas (GHS definition)
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	Gas (GHS definition)
13	Oxidizing liquids	Not applicable	- -	-	-	Gas (GHS definition)
14	Oxidizing solids	Not applicable	- -	-	-	Gas (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Gas (GHS definition)
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to gas substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not applicable	- -	-	-	Gas (GHS definition)
1	Acute toxicity (Dermal)	Not applicable	- -	-	-	Gas (GHS definition)
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	It was classified as "Not classified" because a non-lethal dose (converted 4-hour equivalent value: 100,000 ppm) for rats after inhalation exceeded 5,000 ppm (SIDS (2001)).
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Gas (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Not applicable	- -	-	-	Gas (GHS definition)
2	Skin corrosion/irritation	Not classified	- -	-	-	A skin irritation test was not conducted because it is a gas, but other toxicity test results indicate that it does not irritate the skin (SIDS (2001)). Therefore, it was classified as "Not classified."
3	Serious eye damage/eye irritation	Not classified	- -	-	-	Data in an eye irritation test were not obtained, but results of acute, repeated, and long-term inhalation exposure tests indicate that it does not irritate the eye (SIDS (2001)). Therefore, it was classified as "Not classified."
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, a negative result in a micronucleus test with mice is described (IUCLID (2000)). On the other hand, as for in vitro, there are reports on an equivocal result (IARC 71 (1999)), a negative result (ACGIH (7th, 2001), IUCLID (2000)), and a positive result (NTP DB (Access on June 2013), ACGIH (7th, 2001), IUCLID (2000)) in bacterial reverse mutation tests, but it was negative in an in-vitro chromosomal aberration test and an hprt gene mutation test with cultured mammalian cells. Based on the obtained knowledge, this substance does not present a genotoxic hazard to humans (SIDS (2001)), or it is considered that this substance does not significantly interfere with the genome (ECETOC (2005)).
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it is classified in Group 3 by IARC (IARC 71 (1999)) and A4 by ACGIH (ACGIH (7th, 2001)). The category was changed according to the revised GHS classification guidance for the Japanese government.
7	Reproductive toxicity	Classification not possible	- -	-	-	It is described in SIDS (2001), ECETOC (2005) that in a 13-week inhalation exposure test with male rats, microscopic examination of the testis and epididymis revealed impaired spermatogenesis in mid and high dose groups (7,000, 40,000 ppm, 6 hours/day) (Appleman et al., 1985). On the other hand, it was not reproducible in another test (Reuzel et al. 1986) (in a 13-week inhalation exposure test with three doses including maximum 7,000 ppm, 6 hours/day, there were no changes macroscopically or histopathologically in the testis and epididymis in weanlings or young adults, sperm concentrations, the number of sperm cells with deformed heads/tails, and the number of isolated heads/tails did not increase, and a no-observed-effect concentration (NOEC) was 7,000 ppm for the fertility effects), and contradicting results on male fertility are reported. Other than the above, no exposure effects of the test substance were observed in either a test by inhalation exposure before mating and during the first trimester of gestation or a test by inhalation exposure during the period of fetal organogenesis (SIDS (2001), ECETOC (2005)). From the above results, because it is unknown whether there are effects on male fertility, it was classified as "Classification not possible."
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	It is described that in tests with rats and mice by single inhalation exposure to a gas, central nervous effects or behavioral changes (unsteady gait) via the central nervous system were observed at high concentrations of 200,000 ppm (1 hour) to 800,000 ppm (-19 hours) (ACGIH (7th, 2001), SIDS (2001), ECETOC (2005)). Therefore, it was classified in Category 3 (narcotic effects). Besides, there are no reports on health effects in humans.
9	Specific target organ toxicity - Repeated exposure	Not classified	- -	-	-	In 2-week or 13-week inhalation exposure tests with rats and mice, no effects or only slight effects on the respiratory organs and central nervous system were observed even at the high concentrations above the guidance values for Category 2 (SIDS (2001), ACGIH (7th, 2001)). Although there is no toxicity information on the other routes, this substance was classified as "Not classified" based on the test results in the inhalation route only because it is a gas according to GHS definition, and exposure is normally in the inhalation route.
10	Aspiration hazard	Not applicable	- -	-	-	Gas (GHS definition)

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Classification not possible	- -	-	-	No data available.
11	Hazardous to the aquatic environment (Long-term)	Classification not possible	- -	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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