Item | Information |
---|---|
CAS RN | 76-01-7 |
Chemical Name | Pentachloroethane |
Substance ID | 25B0010 |
Classification year (FY) | FY2013 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2008 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance by the Japanese Government (July, 2013) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Not classified |
- |
- | - | Not combustible (ICSC (2002)). |
7 | Flammable solid | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | Not combustible (ICSC (2002)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, it is reported that there was no death at 1,000 mg/kg in a single dose test with rats, and in a 14-day repeated dose test, three out of five animals died within 24 hours in both males and females after the first administration of 1,000 mg/kg (NTP TR232 (1983)). |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. As for in vivo, there are negative results in all of a chromosomal aberration test, a micronucleus test, and a sister chromatid exchange test with mouse bone marrow cells (NTP TR232 (1983)). On the other hand, as for in vitro, it is reported that it was negative in a bacterial reverse mutation test (IARC 71 (1999), NTP TR232 (1983)), negative (IARC 71 (1999), NTP TR232 (1983)) and positive (IARC 71 (1999)) in chromosomal aberration tests with cultured mammalian cells, and positive in a mouse lymphoma test (IARC 71 (1999), NTP TR232 (1983)). The category was changed according to the revised GHS classification guidance for the Japanese government. |
6 | Carcinogenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because IARC classified it in Group 3 (IARC 71 (1999)). Besides, it is reported that in 2-year oral administration carcinogenicity tests with rats and mice, no increased incidence of tumors was observed in rats, but the incidence of hepatocellular carcinoma was significantly increased in mice (NTP TR232 (1983)). The category was changed according to the revised GHS classification guidance for the Japanese government. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 3 (Narcotic effects) |
Warning |
H336 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
Exposure to pentachloroethane vapour causes mild narcosis in humans (NTP TR232 (1983)), and possible symptoms such as drowsiness, giddiness, and unconsciousness are described (PATTY (6th, 2012)). Therefore, it was classified in Category 3 (narcotic effects). |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | In repeated oral administration test with rats and mice for 13 weeks (rats: 5-250 mg/kg/day, mice: 5-500 mg/kg/day) or 2 years (rats: 75-150 mg/kg/day, mice: 250-500 mg/kg/day) (2-year repeated oral administration test as non-neoplastic changes (NTP TR232 (1983))), a significant and dose-dependent increase in chronic diffuse inflammation of the kidney was observed in male rats within the guidance value range for Category 2, but there is no description of other severe findings. In another test, lesions in the kidney were reported only in male rats which showed increased alpha 2u-globulin hyaline droplets by the administration of pentachloroethane (IARC 71 (1999)). From the above results, it was thought that these were phenomena specific to male rats and did not apply to humans, therefore no serious repeated dose toxicity was found. However, it was difficult to classify it as "Not classified" because tests are a carcinogenicity test or its preliminary dose-finding test, and are not appropriate or sufficient for assessment of repeated-dose toxicity. Therefore, it was classified as "Classification not possible." |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 |
- |
H401 |
P273
P501 |
From 48-hour EC50 = 4.7 mg/L for crustacea (Daphnia magna) (ECETOC TR91, 2003), it was classified in Category 2. |
11 | Hazardous to the aquatic environment (Long-term) | Category 2 |
- |
H411 |
P273
P391 P501 |
Reliable chronic toxicity data were not obtained. It was classified in Category 2 because it is not rapidly degradable (BIOWIN), and it was classified in Category 2 in acute toxicity. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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