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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	7778-54-3
Chemical Name	Calcium hypochlorite
Substance ID	25B0009
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2009 FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solid	Not classified	- -	-	-	Not combustible (ICSC (2005)).
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	- -	-	-	Not combustible (ICSC (2005)).
11	Self-heating substances and mixtures	Not classified	- -	-	-	Not combustible (ICSC (2005)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	From information on water solubility: 21 g/100 mL (25 deg C) (ICSC (2005)), it is recognized that it does not react vigorously with water. The classification was changed according to the revised GHS classification guidance for the Japanese government.
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Category 2	Danger	H272	P370+P378 P210 P220 P221 P280 P501	Because it is classified in Division 5.1, PG II (UN1748) in UNRTDG, it was classified in Category 2.
15	Organic peroxides	Not applicable	- -	-	-	It is an inorganic compound.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	It was classified in Category 4 based on an LD50 value of 790 mg/kg for rats (males) (SIDS (2006)).
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" based on an LD50 value of > 2,000 mg/kg for rabbits (IUCLID (2000)).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	It is described in SIDS (2006) that this substance is corrosive to the skin. And it is described in IUCLID (2000) that it is severely corrosive to rabbit skin (causes burn), and there is a description of pH 11.5 in HSDB (Access on July 2013). Furthermore, this substance is classified in "C; R34" in EU DSD classification and "Skin Corr. 1B H314" in EU CLP classification. It was classified in Category 1 based on the above information.
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	It is described in SIDS (2006) that this substance is corrosive to the skin. And it is described in IUCLID (2000) that it is severely corrosive to rabbit skin (causes burn), and there is a risk of causing severe injury on the eye of experimental animals, and it is described in HSDB (Access on July 2013) that 30-second application to rabbit eyes caused a superficial loss of epithelium from the corneas and conjunctivas, and pH is 11.5. It was classified in Category 1 based on the above information. Besides, this substance is also corrosive to the skin.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	It was classified in Category 1 because it is listed in the Frosch contact allergen list (Frosch et al. Contact Dermatitis 5th Ed. (2011)).
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. As for in vivo, there are no tests on calcium hypochlorite, and among tests on sodium hypochlorite or water in which chlorine was dissolved, there are negative results in a chromosomal aberration test and a micronucleus test with mouse bone marrow cells (SIDS (2006)). And as for in vitro, as the only test on calcium hypochlorite, there is a negative result in a bacterial reverse mutation test (SIDS (2006)). Other than this, there is only one positive result in a bacterial reverse mutation test among tests on sodium hypochlorite or water in which chlorine was dissolved, but all the other bacterial reverse mutation tests were negative, and it is described that data are limited for the positive result (SIDS (2006)). And there are both positive and negative results in in-vitro chromosomal aberration tests, and it is described that data are limited for all of them (SIDS (2006)). The category was changed according to the revised GHS classification guidance for the Japanese government.
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because IARC classified it in Group 3 (IARC 52 (1991)). The category was changed according to the revised GHS classification guidance for the Japanese government.
7	Reproductive toxicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" due to lack of data. Besides, it is reported that there are no developmental effects in offspring in tests in which rats were orally dosed during the organogenesis period (IUCLID (2000)), or before mating through a gestation period (SIDS (2006)), and no reproductive toxicity was observed in a one-generation test with rats (SIDS (2006)), but either test substance is unknown (data in IUCLID (2000)), or hypochlorous acid was used in tests (data in SIDS (2006)). Therefore, it was classified as "Classification not possible."
8	Specific target organ toxicity - Single exposure	Category 2 (central nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	It was classified in Category 2 (central nervous system) based on a report that moderate depression of the central nervous system was observed at the doses (890-1,260 mg/kg) within the guidance value range for Category 2 in an oral acute toxicity test with rats (SIDS (2006)). Besides, it was classified in Category 2 (respiratory organs) in the previous classification based on pulmonary edema in humans by fume exposure described in HSDB (2002). However, it was removed this time because its details are unknown such as being impossible to judge whether it was the effect of exposure to the fume of this substance.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, in 3-month or 2-year tests with rats by drinking water administration of sodium hypochlorite (CAS 7681-52-9), only systemic effects such as reduced weight gain were observed at the doses above the guidance value range (EU-RAR (2007)). And lower values of body weights were found within the guidance value range for Category 2 in a 2-year drinking water administration test with mice (EU-RAR (2007)), but there were no anomalies in pathological examinations, and the target organ is unknown. Therefore, sodium hypochlorite was classified in Category 2 (systemic toxicity).
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 1	Warning	H400	P273 P391 P501	From 48-hour LC50 = 0.005-0.006 mg/L for crustacea (Ceriodaphnia dubia) (SIDS, 2006), it was classified in Category 1.
11	Hazardous to the aquatic environment (Long-term)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 1 because this substance is an inorganic compound, and appropriate data on rapid degradability were not obtained, and due to 133-day NOEC = 0.005 mg/L for fish (Lepomis macrochirus) (SIDS, 2006). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 because this substance is an inorganic compound, and appropriate data on rapid degradability were not obtained, and due to 48-hour LC50 = 0.005-0.006 mg/L or crustacea (Ceriodaphnia dubia) (SIDS, 2006). From the above results, it was classified in Category 1.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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