GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 7646-85-7
Chemical Name Zinc chloride
Substance ID 25B0004
Classification year (FY) FY2013
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Solid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Solid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Solid (GHS definition)
6 Flammable liquids Not applicable
-
-
- - Solid (GHS definition)
7 Flammable solid Not classified
-
-
- - Not combustible (ICSC (2002)).
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- - Solid (GHS definition)
10 Pyrophoric solids Not classified
-
-
- - Not combustible (ICSC (2002)).
11 Self-heating substances and mixtures Not classified
-
-
- - Not combustible (ICSC (2002)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- - From information on water solubility: 432 g/100 g (25 deg C) very good (ICSC (2002)), it is recognized that it does not react vigorously with water.
13 Oxidizing liquids Not applicable
-
-
- - Solid (GHS definition)
14 Oxidizing solids Classification not possible
-
-
- - The classification was not possible due to no data from the prescribed test.
15 Organic peroxides Not applicable
-
-
- - It is an inorganic substance.
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
It was classified in Category 4 from LD50 for rats of 1,100 mg/kg bw (EU-RAR (2004), DFGOT vol. 18 (2002)) and 350 mg/kg bw (EPA Pesticides (1992)).
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, the result in IUCLID, which was the rationale for classification in the previous classification, was LDLo and was not adopted.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
In primary skin irritation tests with rabbits, after open or occlusive application of 0.5 mL of this substance (1% suspension in deionized water) to the dorsal skin, severe irritation was observed in all animals (4/4) in both tests. In the open application test, parakeratosis, hyperkeratosis and inflammatory changes in the epidermis and superficial dermis and acanthosis of the follicular epithelia were observed, and in the occlusive application test, erythema and ulceration were also found (EU-RAR (2004)). It is described in EU-RAR (2004) that this substance is classified as corrosive to the skin according to the EC criteria, and it is concluded that although the test was not according to the guidelines, the results justify classification and labeling (R34). This substance is classified in "R34" in EU DSD classification and "Skin Corr. 1B H314" in EU CLP classification. It was classified in Category 1 based on the above information.
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
There are two cases of persons who were accidentally exposed to concentrated zinc chloride in their eyes (EU-RAR (2004)). It is described that they developed edema followed by permanent cornea scarring, and recovery required 6-28 weeks (EU-RAR (2004)), and this substance is a corrosive substance. It was classified in Category 1 based on the above.
4 Respiratory sensitization Classification not possible
-
-
- - Occupational asthma by soldering fluid is reported in humans (DFGOT vol. 18 (2002)), but the cause is unknown because they were also exposed to ammonium chloride. Therefore, it was classified as "Classification not possible" due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. A positive result is reported in an in vivo chromosomal aberration test with mouse bone marrow on zinc chloride, but a chromosomal aberration test, a micronucleus test, and a dominant lethal test with mice or rats using higher doses of zinc sulfate were negative, and the biological activities of zinc compounds are thought to be caused by zinc cation. Based on the weight of evidence, zinc chloride is not regarded as genotoxic in vivo (EU-RAR (2004)). Besides, as for in vitro, it is reported that it was negative in a bacterial reverse mutation test, negative in a chromosomal aberration test with human lymphocytes, and positive in a micronucleus test with human lymphocytes at an extremely high dose (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), EU-RAR (2004), EHC (2001)). Besides, in the previous classification, chromosomal aberration tests with rats and mice (in vivo somatic cell mutagenicity test) were regarded to be positive, but they were not judged to be positive this time because their reliability is questioned in EU-RAR (2004) and EHC (2001).
6 Carcinogenicity Classification not possible
-
-
- - It was classified as "Classification not possible" because the US EPA classified it in I (IRIS (2005)).
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, in a reproductive toxicity test with mice, reproductive toxicity (decreases in gestation rate, the number of offspring born, and live birth index) was observed, but maternal toxicity was severe because 2-5 out of 10 maternal animals died, and decreased weights of the liver and spleen were found (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). Therefore, it was not used for classification.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory organs)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
In humans, it is reported that inhalation exposure to the fume of zinc chloride caused transient respiratory tract irritation symptoms and severe respiratory disorder (chronic lesions) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). Furthermore, it is reported that soldiers were exposed by inhalation to zinc chloride during training, and some of them developed severe acute adult respiratory distress syndrome (ARDS) and died (PATTY (6th, 2012)), and it is described that fatal cases of respiratory disorder were observed including the people who developed interstitial pulmonary fibrosis by inhalation exposure and died of respiratory failure. Therefore, it was classified in Category 1 (respiratory organs). As for the liver and pancreas adopted as the target organs in the previous classification, it was impossible to identify the corresponding knowledge in EHC 221 (2001). And the other assessment documents (EU-RAR (2004), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), etc.) did not have such a description, therefore these were removed from the target organs.
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - Classification not possible due to lack of data. Mouse data in DFGOT vol. 18 (2002) adopted in the previous classification are not data of inhalation exposure to zinc chloride alone but data of inhalation exposure to the mixture of many compounds including hexachloroethane, potassium nitrate, and zinc oxide, therefore it is not appropriate to use it for classification. There are no reliable data on repeated exposure to zinc chloride alone in the other assessment documents (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), EU-RAR (2004)).
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1


Warning
H400 P273
P391
P501
From 72-hour EC50 = 0.065 mg Zn/L for diatoms (Nitzschia closteium) (a converted value equivalent to this substance: 0.135 mg/L) (EHC 221, 2001, Initial Risk Assessment (NITE, CERI, NEDO, 2008)), it was classified in Category 1.
11 Hazardous to the aquatic environment (Long-term) Category 1


Warning
H410 P273
P391
P501
It was classified in Category 1 due to unknown behavior of the metal compound in water, and 72-hour NOEC = 15.6 micro gZn/L (a converted value equivalent to this substance: 32.5 microg/L) for algae (Pseudokirchneriella subcapitata) (EU-RAR, 2010).
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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