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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	61788-46-3
Chemical Name	Cocoalkylamine
Substance ID	25A0082
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Not classified	- -	-	-	From a flash point of 100-199 deg C (closed cup) (GESTIS (Access on December 2013)) above 93 deg C, it was classified as "Not classified."
7	Flammable solid	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 255 deg C (GESTIS (Access on December 2013)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	There is a report on four LD50 values for rats of 1,300 mg/kg (males and females), > 2,000 mg/kg (males), 2,820 mg/kg (females), and 2,040 mg/kg (EU-RAR (2008)). It was classified as "Not classified" (Category 5 in UN GHS classification) to which the most values corresponded.
1	Acute toxicity (Dermal)	Category 4	Warning	H312	P302+P352 P362+P364 P280 P312 P321 P501	There is a report on LD50 values of > 2,000 mg/kg for rats and > 1,600 mg/kg for rabbits (EU-RAR (2008)). It was classified in Category 4 to which the minimum LD50 value corresponded.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, it is reported that there was no death case in a 1-hour inhalation test with rats at 0.099 mg/L (converted 4-hour equivalent value: 0.0325-0.0495 mg/L (3.93-4.13*10-4 ppm)) (EU-RAR (2008)), but the category cannot be determined. Because the test concentration is lower than 90% of the saturated vapour pressure concentration (0.78-0.82 mg/L), a reference value in the unit of ppm was applied as vapour with little mist.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	There is a report on several skin irritation tests (according to OECD TG 404) with rabbits in EU-RAR (2008), and it is described that in a test in which this substance (purity: 100%) was applied semi-occlusively for 4 hours, the average scores after 72 hours were 3.0 for erythema and 3.0 for edema, erythema and edema disappeared within seven days, but scarring persisted after 21 days, and the substance was judged to be corrosive in EU-RAR (2008). Therefore, it was classified in Category 1.
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Although the information on eye irritation of this substance was not obtained, because this substance is corrosive to the skin, it was classified in Category 1.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. It is described in EU-RAR (2008) that positive response was observed in 2 out of 10 animals in a maximization test with guinea pigs. However, it was classified as "Classification not possible" because the decision cannot be made on the test results alone.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There are no in vivo data, and as for in vitro, it was negative in a bacterial reverse mutation test (EU-RAR (2008), HPVIS (Access on December 2013)).
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 3 (narcotic effects, respiratory tract irritation)	Warning	H336 H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	It is described that after gavage administration (500-2,000 mg/kg) to rats, apathia, irregular postures, uncoordinated movements, reduced reflexes, cyanosis, salivation, piloerection, etc. were observed at all doses, and the symptoms persisted seven days after the dose (EU-RAR (2008)). And an irritation of the muzzle was found after inhalation exposure in rats (vapour, 0.0325-0.0495 mg/L (converted 4-hour equivalent value)) (EU-RAR (2008)). Furthermore, after dermal exposure in rats, hunched posture, abnormal gait, lethargy, and decreased respiration rate were observed at 2,000 mg/kg (EU-RAR (2008)). From the above results, it was classified in Category 3 (narcotic effects, respiratory tract irritation).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data.
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 1	Warning	H400	P273 P391 P501	From 48-hour EC50 = 0.045 mg/L for crustacea (Daphnia magna) (EU-RAR, 2008), it was classified in Category 1.
11	Hazardous to the aquatic environment (Long-term)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (a degradation rate by BOD: 56% (EU-RAR, 2008)), and 21-day NOEC = 0.013 mg/L for crustacea (Daphnia magna) (EU-RAR, 2008). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to being not rapidly degradable (a degradation rate by BOD: 56% (EU-RAR, 2008)), and 96-hour LC50 = 0.16 mg/L for fish (Oncorhynchus mykiss) (EU-RAR, 2008). From the above results, it was classified in Category 1.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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