GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 39430-27-8
Chemical Name Nickel carbonate tetrahydrate
Substance ID 25A0076
Classification year (FY) FY2013
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Solid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Solid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Solid (GHS definition)
6 Flammable liquids Not applicable
-
-
- - Solid (GHS definition)
7 Flammable solid Not classified
-
-
- - It is estimated to be not combustible. (Nickel carbonate anhydrate is not combustible (ICSC (2001)))
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- - Solid (GHS definition)
10 Pyrophoric solids Not classified
-
-
- - It is estimated to be not combustible. (Nickel carbonate anhydrate is not combustible (ICSC (2001)))
11 Self-heating substances and mixtures Not classified
-
-
- - It is estimated to be not combustible. (Nickel carbonate anhydrate is not combustible (ICSC (2001)))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- - From the information of being insoluble in water (NITE Chemical Risk Information Platform (NITE-CHRIP) (Access on August 2013)), it is recognized that it does not react vigorously with water.
13 Oxidizing liquids Not applicable
-
-
- - Solid (GHS definition)
14 Oxidizing solids Classification not possible
-
-
- - It is an inorganic compound which does not contain halogen but contains oxygen, however, the classification is not possible due to no data.
15 Organic peroxides Not applicable
-
-
- - It is an inorganic compound.
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- - It was classified as "Not classified" (Category 5 in UN GHS classification) based on a report on an LD50 value of > 2,000 mg/kg for rats and death of 1/6 animals at 2,000 mg/kg (JECDB (Access on October 2013)).
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- - Classification not possible due to lack of data.
3 Serious eye damage/eye irritation Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Respiratory sensitization Category 1


Danger
H334 P304+P340
P342+P311
P261
P284
P501
Nickel and its compounds are classified as occupational sensitizers to the airway Group 2 in the Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2013), "R42" in EU DSD classification, and "Resp. Sens. 1 H334" in EU CLP classification. There is the knowledge that this substance is insoluble in water and is hardly soluble in the pulmonary fluid (Oller et al., J. Environ Monit., 11, 823, 2009). However, based on the classification by the Japan Society For Occupational Health (JSOH) and the EU CLP classification, it was classified in Category 1.
4 Skin sensitization Category 1


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501
It was classified in Category 1 because nickel and its compounds are classified as skin sensitizers Group 1 in the Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2013), "R43" in EU DSD classification, and "Skin. Sens. 1 H317" in EU CLP classification.
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data. There are no in vivo data, and as for in vitro, it was negative in a bacterial reverse mutation test and a chromosomal aberration test with cultured mammalian cells (JECDB (Access on September 2013)). Besides, for the anhydrate, there is a positive result in an in vitro chromosomal aberration test with Chinese hamster ovary (CHO) cells (EU-RAR (2008)).
6 Carcinogenicity Category 1A


Danger
H350 P308+P313
P201
P202
P280
P405
P501
It was classified in Category 1A because nickel carbonate (CAS: 3333-67-3), the anhydrate of this substance, is classified in 1 by IARC (IARC 100C (2012)), "Carc. Cat. 1; R49" in EU DSD classification, and "Carc. 1A H350i" in EU CLP (ESIS (Access on Sept 2013)).
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG422) with rats in the oral route (gavage), no fertility effects were observed even at the dose (10 mg/kg/day) where effects were found in parent animals. And no effects were seen in offspring (JECDB (Access on October 2013)). However, because it is a screening test, and there are no sufficient reports on developmental toxicity, it was classified as "Classification not possible."
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - Death of one animal was observed at 2,000 mg/kg in rats after gavage administration. The animal showed no effects except for autolysis in the stomach and small intestine, which was thought to be postmortem changes (JECDB (Access on October 2013)), but the details are unknown. Therefore, it was classified as "Classification not possible."
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats by gavage administration, a death case (1/12 animals) was observed in females at the dose (4.7 mg/kg/day (converted guidance value)) within the guidance value range for Category 1, but the cause of death was unknown (JECDB (Access on October 2013)). Because the doses of the test did not cover the guidance value range, it was impossible to use the data for classification as those in the oral route.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1


Warning
H400 P273
P391
P501
From 72-hour EC50 = 0.48 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2005)), it was classified in Category 1.
11 Hazardous to the aquatic environment (Long-term) Category 1


Warning
H410 P273
P391
P501
If chronic toxicity data are used, then it is classified in Category 1 due to no appropriate data obtained on rapid degradability, and 21-day NOEC = 0.012 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2005)).
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to no appropriate data obtained on rapid degradability, and 96-hour LC50 > 4.5 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2005)).
By drawing a comparison between the above results, it was classified in Category 1.
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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