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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	10026-24-1
Chemical Name	Cobalt(II) sulfate heptahydrate
Substance ID	25A0074
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solid	Not classified	- -	-	-	Not combustible (ICSC (2001)).
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	- -	-	-	Not combustible (ICSC (2001)).
11	Self-heating substances and mixtures	Not classified	- -	-	-	Not combustible (ICSC (2001)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	From the information of being soluble in water (Merck (14th, 2006)), it is recognized that it does not react vigorously with water.
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound which does not contain halogen but contains oxygen, however, the classification is not possible due to no data.
15	Organic peroxides	Not applicable	- -	-	-	It is an inorganic compound.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	It was classified in Category 4 based on 761 mg/kg, which was obtained by molecular weight conversion of an LD50 value of 420 mg/kg for cobalt sulfate anhydrate for rats (NTP TR 471 (1998)).
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	Data lack if it is limited to information on this substance. However, for cobalt and its compounds, it is described in DFGOT vol.23 (2006) that sensitization of the respiratory organs in humans was concluded from investigations on workers in hard metal production/processing and diamond polishing. Therefore, it was classified in Category 1.
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	It is described in DFGOT vol.23 (2006) that in two maximization tests in humans, positive reactions were observed in 10 out of 25 subjects and 42 out of 987 subjects, respectively. Furthermore, three tests with guinea pigs were reported, and it is described that it was positive (positive rate of 100%), although the positive control is unknown in all. Therefore, it was classified in Category 1.
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	As for in vivo, cobalt chloride was positive in a micronucleus test and a chromosomal aberration test with mouse bone marrow cells (CICAD 69 (2006)). And cobalt was positive in a test in which oxidatively damaged DNA was investigated on the liver, kidney, and lung of rats (CICAD 69 (2006)). As for in vitro, this substance was positive in a bacterial reverse mutation test (CICAD 69 (2006), NTP DB (Access on August 2013)), and although it is not this substance, cobalt compounds and cobalt metal were reported to be positive in a chromosomal aberration test and a micronucleus test (CICAD 69 (2006)). From the above, although there are no in vivo data on this substance, cobalt chloride, the related substance of this substance, was positive in vivo, and cobalt compounds including this substance were positive as a whole also for in vitro. Therefore, it was classified in Category 2.
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	This substance was classified in Category 2 because it is classified in Group 2B by IARC (IARC 86 (2006)).
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	As for fertility, in a 13-week inhalation exposure test with mice, delay in the estrus cycle was observed (CICAD 69 (2006)). As for developmental toxicity, in a developmental toxicity test with rats in the oral route (gavage), skeletal malformations and malformations in the urogenital organs were found at the dose where maternal toxicity (decreased food consumption, increased relative weights of the liver, adrenal gland, and spleen, increases in urea nitrogen and creatinine levels, decreases in albumin and blood sugar) was seen (IARC (2006), Szakmary, E. et al. (2001)). Therefore, it was classified in Category 2.
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data.
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs), Category 2 (male genetic organs)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	As a result of 13-week inhalation exposure to the aerosol of this substance in rats and mice at concentrations of 0.0003-0.03 mg/L, squamous metaplasia in the larynx in rats and mice from 0.0003 mg/L within the guidance value range for Category 1, inflammation in the lung in rats at or above 0.003 mg/L, and degeneration of the olfactory epithelium, etc. in the nasal cavity in rats and mice at or above 0.01 mg/L were observed. Furthermore, atrophy of the testis and decreased weights of the testis and epididymis were found in mice within the guidance value range for Category 2 (0.03 mg/L) (NTP TOX 5 (1991), CICAD 69 (2006)). From the above, it was classified in Category 1 (respiratory organs), Category 2 (male genitalia).
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Classification not possible	- -	-	-	No data available.
11	Hazardous to the aquatic environment (Long-term)	Classification not possible	- -	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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