NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	7446-19-7
Chemical Name	Zinc sulfate monohydrate
Substance ID	25A0071
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solid	Not classified	- -	-	-	The anhydrate: not combustible (ICSC (2004)) The not combustible: not combustible (ICSC (2001))
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	- -	-	-	The anhydrate: not combustible (ICSC (2004)) The not combustible: not combustible (ICSC (2001))
11	Self-heating substances and mixtures	Not classified	- -	-	-	The anhydrate: not combustible (ICSC (2004)) The not combustible: not combustible (ICSC (2001))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	From the information of being soluble in water (Merck (2006)), it is recognized that it does not react vigorously with water.
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Classification not possible	- -	-	-	No data available.
15	Organic peroxides	Not applicable	- -	-	-	It is an inorganic substance.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	For zinc sulfate heptahydrate (CAS: 7446-20-0), there is a report on LD50 = 1,000-2,000 mg/kg (EU-RAR (2004)), 1,757.17 mg/kg (males), and 1,229.27 mg/kg (females) (Japan Crop Protection Association (1994)) for rats. When these values were converted to zinc sulfate monohydrate, they were LD50 = 624.1- 1,248.2 mg/kg bw, 1096.6 mg/kg (males), and 767.2 mg/kg (females), and it was classified in Category 4. [Note] Please also refer to the classification results on zinc sulfate heptahydrate (CAS RN 7446-20-0) and zinc sulfate, the anhydrate of this substance (CAS RN 7733-02-0).
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, for zinc sulfate heptahydrate (CAS: 7446-20-0), LD50 > 2,000 mg/kg bw for rats is reported (EU-RAR (2004)). When this value was converted to zinc sulfate anhydrate, it was LD50 > 1,248 mg/kg bw. [Note] Please also refer to the classification results on zinc sulfate heptahydrate (CAS RN 7446-20-0) and zinc sulfate, the anhydrate of this substance (CAS RN 7733-02-0).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Vapour exposure is thought to be difficult because it is described in NITE CHRIP (2012) that the vapour pressure of zinc sulfate heptahydrate (CAS: 7446-20-0) is "practically 0 mmHg." It was thought to be similar for zinc sulfate monohydrate, therefore, it was classified as "Not applicable." [Note] Please also refer to the classification results on zinc sulfate heptahydrate (CAS RN 7446-20-0) and zinc sulfate, the anhydrate of this substance (CAS RN 7733-02-0).
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Not classified	- -	-	-	In a primary skin irritation test with rabbits (according to Directive 92/69/EEC B.4 and OECD guideline 404) on zinc sulfate heptahydrate (CAS: 7446-20-0), as a result of 4-hour semi-occlusive application of 0.5 g of this substance to the auricle, no irritation was observed (EU-RAR (2004)). Furthermore, in another primary skin irritation test with rabbits on zinc sulfate heptahydrate, after 0.5 g of this substance was applied to two sites of the dorsal skin (normal skin and abraded skin) for 4 hours, no skin reactions were observed in normal skin or abraded skin (Japan Crop Protection Association (1994)). Moreover, it is described in EU-RAR (2004) that zinc sulfate heptahydrate is not corrosive to the skin, and it is concluded that based on the test according to EU and OECD guidelines, zinc sulfate is considered not irritating/corrosive to the skin. Based on the above information, it was classified as "Not classified."
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	In an eye irritation/corrosion test with rabbits (according to Directive 92/69/EEC B.5 and OECD guideline 405) on zinc sulfate heptahydrate (CAS: 7446-20-0), corneal injury, conjunctival redness, chemosis, and eye discharge were observed. Yellow/white spots were found in the tissue of the lower eyelid, nictitating membrane, and/or sclera from 7 days after application, and none of these were reversible during the test period (EU-RAR (2004)). It is described in EU-RAR (2004) that these spots were signs of necrosis, and according to EU criteria, this substance is considered to cause severe ocular irritation and should be labelled as R41. Besides, zinc sulfate is classified in "R41" in EU DSD classification and "Eye dam. 1" in EU CLP classification. Based on the above information, it was classified in Category 1.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. [Note] Please also refer to the classification results on zinc sulfate heptahydrate (CAS RN 7446-20-0) and zinc sulfate, the anhydrate of this substance (CAS RN 7733-02-0).
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Most information on zinc sulfate has no description of the anhydrate or hydrate, and there are no data in which the monohydrate is mentioned. Besides, the information on the anhydrate is limited to a positive result in an in-vivo comet assay with mice (NITE (2008)). And as the in vivo information on zinc sulfate (no description of the anhydrate or hydrate), there are negative results in all of a chromosomal aberration test, a micronucleus test, and a dominant lethal test (NITE (2008), EU-RAR (2004), ATSDR (2009), EHC (2001), IUCLID (2000), HSDB (2006)). Furthermore, as the in vitro information on zinc sulfate (no description of the anhydrate or hydrate), it was negative in a bacterial reverse mutation test (NITE (2008), EU-RAR (2004), ATSDR (2009), EHC (2001), IUCLID (2000), HSDB (2006)) and a chromosomal aberration test with cultured mammalian cells (NITE (2008), EU-RAR (2004), IUCLID (2000), HSDB (2006)) and positive in an HGPRT gene mutation test with cultured mammalian cells (IUCLID, 2000). [Note] Please also refer to the classification results on zinc sulfate heptahydrate (CAS RN 7446-20-0) and zinc sulfate, the anhydrate of this substance (CAS RN 7733-02-0).
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" due to no classification results by other organizations or toxicity information.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. [Note] Please also refer to the classification results on zinc sulfate heptahydrate (CAS RN 7446-20-0) and zinc sulfate, the anhydrate of this substance (CAS RN 7733-02-0).
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. [Note] Please also refer to the classification results on zinc sulfate heptahydrate (CAS RN 7446-20-0) and zinc sulfate, the anhydrate of this substance (CAS RN 7733-02-0).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. [Note] Please also refer to the classification results on zinc sulfate heptahydrate (CAS RN 7446-20-0) and zinc sulfate, the anhydrate of this substance (CAS RN 7733-02-0).
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Classification not possible	- -	-	-	No data available.
11	Hazardous to the aquatic environment (Long-term)	Classification not possible	- -	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

To GHS Information