GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 24800-44-0
Chemical Name Tripropylene glycol
Substance ID 25A0042
Classification year (FY) FY2013
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Not classified
-
-
- - From a flash point of 141 deg C (closed cup) (ICSC (1999)) above 93 deg C, it was classified as "Not classified."
7 Flammable solid Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 260 deg C (GESTIS (Access on October 2013)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule.
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- - It was classified as "Not classified" based on reports on LD50 values for rats of > 2,000 mg/kg (JECDB (Access on August 2013), SIDS (2004)) and 3,000 mg/kg (SIDS (2004)).
1 Acute toxicity (Dermal) Not classified
-
-
- - It was classified as "Not classified" based on a report on an LD50 value of > 16,300 mg/kg for rabbits (IUCLID (2000)).
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- - It is reported in IUCLID (2000) that there was no irritation in a skin irritation test with rabbits, but the details such as application time are unknown. Therefore, it was classified as "Classification not possible."
3 Serious eye damage/eye irritation Classification not possible
-
-
- - It is reported in IUCLID (2000) that there was no irritation in an eye irritation test with rabbits, but the details such as application time are unknown. Therefore, it was classified as "Classification not possible."
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data. Three are no in vivo data, and as for in vitro, it was negative in a bacterial reverse mutation test and a chromosomal aberration test with cultured mammalian cells (SIDS (2004), JECDB (Access on October 2013), IUCLID (2000), NTP DB (Access on August 2013)).
6 Carcinogenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data. In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats in the oral route, no effects on fertility were observed (JECDB (Access on October 2013), SIDS (2004)). Because it is a result of a screening test, and sufficient data on developmental toxicity were not obtained, it was classified as "Classification not possible."
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, it is reported in a gavage administration test with rats, no toxicity effects were observed at the upper-limit concentration of the Guidance (2,000 mg/kg) (JECDB (Access on October 2013)). Therefore, it is thought to correspond to "Not classified" in the oral route. However, because of no toxicity information on the other routes, it was classified as "Classification not possible" due to lack of data.
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - It is described that in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats, no toxicity effects were seen at up to the doses within the guidance value range for Category 2, and salivation and higher liver and kidney weights were observed at the highest dose of 1,000 mg/kg/day (converted guidance value: 455-544 mg/kg/day) (JECDB (Access on October 2013), SIDS (2004)). Therefore, it is thought to correspond to "Not classified" in the oral route. However, because of no toxicity information on the other routes, it was classified as "Classification not possible" due to lack of data.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified
-
-
- - From 72-hour EbC50 > 1000 mg/L for algae (Pseudokirchneriella subcapitata) (SIDS, 2004), 24-hour EC50 > 1000 mg/L for crustacea (Daphnia magna) (SIDS, 2004), and 96-hour LC50 > 1000 mg/L for fish (Oryzias latipes) (SIDS, 2004), it was classified as "Not classified."
11 Hazardous to the aquatic environment (Long-term) Not classified
-
-
- - If chronic toxicity data are used, then it is classified as "Not classified" due to being not rapidly degradable (not readily degradable, a degradation rate by BOD: 2% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1995)), 72-hour NOEC (b) > 1000 mg/L for algae (Pseudokirchneriella subcapitata) (SIDS, 2004), and 21-day NOEC (reproduction) > 1000 mg/L for crustacea (Daphnia magna) (SIDS, 2004).
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" because it corresponds to "Not classified" in acute toxicity, and it is not water-insoluble (water-soluble, HSDB, 2013).
From the above results, it was classified as "Not classified."
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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