GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 112-35-6
Chemical Name Triethylene glycol monomethyl ether
Substance ID 25A0041
Classification year (FY) FY2013
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Not classified
-
-
- - From a flash point of 114.4 deg C (closed cup) (ICSC (2008)) above 93 deg C, it was classified as "Not classified."
7 Flammable solid Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 210 deg C (ICSC (2008)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
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-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule.
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- - It was classified as "Not classified" based on reports on LD50 values for rats of 11,300 mg/kg (SIDS (2005)), 11,800 mg/kg (SIDS (2005), ECETOC TR64 (1995), ECETOC TR95 (2005), PATTY (6th, 2012)), and 12,600 mg/kg (SIDS (2005)).
1 Acute toxicity (Dermal) Not classified
-
-
- - It was classified as "Not classified" based on an LD50 value for rabbits of 7,400 mg/kg (SIDS (2005), ECETOC TR64 (1995), ECETOC TR95 (2005), PATTY (6th, 2012)).
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Not classified
-
-
- - It was classified as "Not classified" based on a report that there were no dead animals in an inhalation test with rats exposed to 200 mg/L (1 hour) (converted 4-hour equivalent value: 50 mg/L) (SIDS (2005)). Besides, the test concentration is higher than the saturated vapour pressure concentration (0.08 mg/L), a reference value in the unit of mg/L was applied as mist.
2 Skin corrosion/irritation Not classified
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-
- - It is described that there was slight irritation in a 24-hour skin irritation test with rabbits (SIDS (2005)). As for effects on humans, it is described that there was slight irritation after 72-hour application to 20 men and women (SIDS (2005)). Therefore, it was classified as "Not classified" (Category 3 in UN GHS classification).
3 Serious eye damage/eye irritation Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, it was assessed to be slightly irritating in a Draize test with rabbits (SIDS (2005)).
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
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-
- - It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a micronucleus test with mouse bone marrow cells (SIDS (2005), ECETOC TR64 (1995), ECETOC TR95 (2005)). As for in vitro, it was negative in a bacterial reverse mutation test and a gene mutation test with cultured mammalian cells (SIDS (2005), ECETOC TR64 (1995), ECETOC TR95 (2005), IUCLID (2000)).
6 Carcinogenicity Classification not possible
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-
- - Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
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-
- - Classification not possible due to lack of data. Besides, as for developmental toxicity, there is a report on developmental toxicity tests with rats and rabbits in the oral route, and developmental effects including skeletal variations and reduced weight gain were observed in rats at 1,250 mg/kg bw/day and rabbits at 1,500 mg/kg bw/day (SIDS (2005), PATTY (6th, 2012), ECETOC TR95 (2005)). These effects were not used for the rationale for the classification because they were slight. Besides, it is described in PATTY (6th. 2012) that the NOAEL for maternal toxicity was very near the NOAEL for developmental toxicity, and this substance was not selectively toxic to the conceptus. Because there are no reports on fertility, it was classified as "Classification not possible."
8 Specific target organ toxicity - Single exposure Not classified
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-
- - In gavage administration to rats, death was observed at the highest dose (16 mL/kg), no clear symptoms are described for the other concentrations (4-8 mL/kg) above the guidance value range (SIDS (2005)). Furthermore, it is reported that in inhalation exposure (mist) in rats, no death or toxic signs were found at the dose (converted 4-hour equivalent value: 50 mg/L) above the guidance value range (SIDS (2005)), and it is described that there were no toxicity effects after exposure to the saturated vapour concentration (detailed concentration: unknown) (ECETOC TR95 (2005), PATTY (6th, 2012)). In a dermal administration test with rabbits, death was observed at the highest dose (10 g/kg), but no toxicity effects were seen at the concentrations (2.5-5 g/kg) above the guidance value range (SIDS (2005)). From the above results, it was judged as "Not classified."
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - It is reported that in a 13-week oral dose (drinking water) test with rats, and dermal exposure tests with rats exposed for 13 weeks and rabbits exposed for 21 days, all of which used higher doses (400 mg/kg/day or above) above the guidance value range for Category 2, effects on the liver and testis after oral exposure and no effects (rabbits) or effects on the testis (rats) after dermal exposure were observed (SIDS (2005), ECETOC TR95 (2005), HSDB (Access on October 2013)). From the above, it corresponds to "Not classified" in the oral and dermal routes, but toxicity effects are unknown in the inhalation route. Therefore, it was classified as "Classification not possible" due to lack of data.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified
-
-
- - From 72-hour EC50 > 500 mg/L for algae (Desmodesmus subspicatus) (SIDS, 2005), 48-hour EC50 > 10000 mg/L for crustacea (Daphnia magna) (SIDS, 2005), and 72-hour EC50 > 10000 mg/L for fish (Pimephales promelas) (SIDS, 2005), it was classified as "Not classified."
11 Hazardous to the aquatic environment (Long-term) Not classified
-
-
- - Reliable chronic toxicity data were not obtained. Because it is not water-insoluble (water solubility: miscible, HSDB, 2013), and it was classified as "Not classified" in acute toxicity, it was classified as "Not classified."
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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