Item | Information |
---|---|
CAS RN | 92-87-5 |
Chemical Name | Benzidine |
Substance ID | 25A0033 |
Classification year (FY) | FY2013 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance by the Japanese Government (July, 2013) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | |
Model SDS by MHLW (External link) | |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
7 | Flammable solid | Classification not possible |
- |
- | - | No data available. |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
14 | Oxidizing solids | Not applicable |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine. |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
It was classified in Category 4 based on a report on an LD50 value of 309 mg/kg for rats (Environmental Risk Assessment for Chemical Substances vol. 6, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2008), ATSDR (2001)). |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Category 2 |
Warning |
H341 |
P308+P313
P201 P202 P280 P405 P501 |
As for in vivo, it was all positive in micronucleus tests with somatic cells of mice and rats, a chromosomal aberration test with mouse somatic cells, a DNA adduct formation test with mouse somatic cells, a DNA damage test and an unscheduled DNA synthesis test with rat somatic cells (ATSDR (2001), IRIS (2012), IARC 100F (2012)). As for In vitro, it was positive in a bacterial reverse mutation test, and a gene mutation test and a chromosomal aberration test with cultured mammalian cells (ATSDR (2001), IRIS (2012), IARC 100F (2012), ACGIH (7th, 2001)). Therefore, it was classified in Category 2. |
6 | Carcinogenicity | Category 1A |
Danger |
H350 |
P308+P313
P201 P202 P280 P405 P501 |
Because this substance is classified in 1 by IARC (IARC (2012)), A1 by ACGIH (ACGIH (1985)), A by EPA (EPA (1986)), K by NTP (NTP (1980)), it was classified in Category 1A. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. No report on reproductive and developmental toxicity was obtained. |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, after oral administration to mice, a delayed hypersensitivity response and alterations in lymphocyte blastogenesis, natural killer cell activity, and relative spleen weights are reported although doses are unknown (ATSDR (2001)). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (liver, brain), Category 2 (bone marrow, spleen, ovary, urinary bladder) |
Danger Warning |
H372
H373 |
P260
P264 P270 P314 P501 |
It is described that in a test with mice given 33-month administration of the dihydrochloride of this substance by drinking water, liver cell alterations, bile duct hyperplasia, brain vacuolization at the doses (a converted value equivalent to this substance: 2.7-8.2 mg/kg/day) within the guidance value range for Category 1, and megakaryocytosis of the bone marrow, hemosiderosis of the spleen, atrophy of the ovary, bladder epithelial hyperplasia at the doses (a converted value equivalent to this substance: 11.7-27.2 mg/kg/day) within the guidance value range for Category 2 were observed (IRIS (1995), Environmental Risk Assessment for Chemical Substances vol. 6, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2008), ATSDR (2001)). Therefore, the liver, brain, bone marrow, spleen, ovary, and urinary bladder were thought to be target organs. From the above, it was classified in Category 1 (liver, brain), Category 2 (bone marrow, spleen, ovary, urinary bladder). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 |
- |
H401 |
P273
P501 |
From 96-hour LC50 = 2.5 mg/L for fish (Notropis lutrensis) (CEPA, 1993), it was classified in Category 2. |
11 | Hazardous to the aquatic environment (Long-term) | Category 2 |
- |
H411 |
P273
P391 P501 |
Reliable chronic toxicity data were not obtained. Because it is not rapidly degradable (BIOWIN), and it was classified in Category 2 in acute toxicity, it was classified in Category 2. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
|