Item | Information |
---|---|
CAS RN | 3648-20-2 |
Chemical Name | Dialkyl(C=11) 1,2-benzenedicarboxylate |
Substance ID | 25A0024 |
Classification year (FY) | FY2013 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance by the Japanese Government (July, 2013) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
7 | Flammable solid | Classification not possible |
- |
- | - | No data available. |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 293 deg C (IUCLID). |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
14 | Oxidizing solids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | It is a solid with a melting point of 55 deg C or lower, but the classification is not possible due to no data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | It was classified as "Not classified" based on a report on an LD50 value of > 15,800 mg/kg for rats (PATTY (6th, 2012)). |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | It was classified as "Not classified" based on a report on an LD50 value of > 7,940 mg/kg for rabbits (PATTY (6th, 2012)). |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there is information in ECHA (Access on October 2013) that after 24-hour application to the skin of rabbits, slight erythema was observed. This information was not used for classification because it is from the information source outside the List. |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, as reference information, there is information in ECHA (Access on October 2013) that after application to rabbits, slight irritation in the conjunctiva was observed but disappeared within 48 hours. This information was not used for classification because it is from the information source outside the List. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, it is described in ECHA (Access on October 2013) that in a human repeated insult patch test (HRIP) in 104 persons in which the undiluted liquid of this substance was used, no evidence of sensitization was obtained. This information was not used for classification because it is from the information source outside the List. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There are no in vivo data. As for in vitro, it was negative in a bacterial reverse mutation test and a chromosomal aberration test with cultured mammalian cells (PATTY (6th, 2012), NTP DB (Access on August 2013), IUCLID (2000)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, it is described that in a 3-week diet administration test with rats, effects in blood biochemistry tests were observed at the dose (64.6 mg/kg/day (converted guidance value)) within the guidance value range for Category 2 (IUCLID (2000)), or effects on liver and kidney weights were found at the doses above the guidance value range for Category 2 (HSDB (2009)). However, effects on the proliferation of hepatic peroxisome were mainly investigated in this test, and target organs for histopathological examinations were limited, therefore it was judged to be inappropriate to use for classification. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Not classified |
- |
- | - | From 48-hour EC50 > 0.02 mg/L for crustacea (Daphnia magna) (AQUIRE, 2013), and LC50 > 0.22 mg/L for fish (Cyprinodon variegatus) (AQUIRE, 2013), it was classified as "Not classified." |
11 | Hazardous to the aquatic environment (Long-term) | Category 4 |
- |
H413 |
P273
P501 |
If chronic toxicity data are used, there are data: 21-day NOEC (lethal) > 0.059 mg/L for crustacea (Daphnia magna) (AQUIRE, 2013). Appropriate data on rapid degradability were not obtained, and it has a bioaccumulation potential (log Pow = 4.95 (IUCLID, 2000)). Therefore, it was classified in Category 4. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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