GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 2432-99-7
Chemical Name 11-Aminoundecanoic acid
Substance ID 25A0005
Classification year (FY) FY2013
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Solid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Solid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Solid (GHS definition)
6 Flammable liquids Not applicable
-
-
- - Solid (GHS definition)
7 Flammable solid Classification not possible
-
-
- - No data available.
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- - Solid (GHS definition)
10 Pyrophoric solids Classification not possible
-
-
- - No data available.
11 Self-heating substances and mixtures Classification not possible
-
-
- - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Solid (GHS definition)
14 Oxidizing solids Not applicable
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule.
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- - It was classified as "Not classified" based on the report that in an administration test with rats (females), death of 1/5 animals at 14,700 mg/kg and death of 5/5 animals at 21,500 mg/kg were observed (NTP TR216 (1982)) and two LD50 values for rats of 21,500-14,700 mg/kg (females) and > 15,000 mg/kg (males, females) (SIDS (2005)).
1 Acute toxicity (Dermal) Not classified
-
-
- - It was classified as "Not classified" based on a reported LD0 value of > 2,000 mg/kg for rats (males, females) (SIDS (2005)).
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Not classified
-
-
- - It was classified as "Not classified" because it is described that there was no irritation in a skin irritation test with rabbits (SIDS (2002)).
3 Serious eye damage/eye irritation Not classified
-
-
- - It was classified as "Not classified" because it is described that there was no irritation in an eye irritation test with rabbits (SIDS (2002)).
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Not classified
-
-
- - It is reported in SIDS (2002) that it was negative in a maximization test with guinea pigs (according to OECD TG 406). Because the test meets the OECD guideline regarding the number of animals in a test group (total 30) and a method of applying test substance, etc., it was classified as "Not classified."
5 Germ cell mutagenicity Classification not possible
-
-
- - It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it is reported that it was negative in a micronucleus test and a chromosomal aberration test with mouse bone marrow cells, and negative in an unscheduled DNA synthesis test with rat hepatocytes and a DNA-binding test with the liver, kidney, and urinary bladder of rats (SIDS (2005), NTP DB (Access on June 2013)). As for in vitro, it was negative in a bacterial reverse mutation test, a chromosomal aberration test and a mouse lymphoma test with cultured mammalian cells (SIDS (2005), NTP DB (Access on June 2013)).
6 Carcinogenicity Classification not possible
-
-
- - It was classified as "Classification not possible" because it is classified in Group 3 in IARC (1987).
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data. There are no data on fertility. As for developmental toxicity, in a developmental toxicity test with rats, slight skeletal variations, which were thought to be related to growth retardation were observed, but no malformations were found (SIDS (2005)).
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - Classification not possible due to lack of data.
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - It is described that in 4-week and 13-week oral dose tests (in the diet) with rats and a 13-week oral dose test (in the diet) with mice, effects on the kidney (tubular dilatation, mineralization, lesions of the renal papilla, transitional-cell hyperplasia) were observed all at the doses (converted guidance value: 550 mg/kg/day or above) above the guidance values for Category 2 (SIDS (2005), NTP TR216 (1982)). Therefore, it corresponds to "Not classified" in the oral route. However, because there is no information on repeated exposure in the other routes, the classification is not possible due to lack of data.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3
-
-
H402 P273
P501
From 72-hour ErC50 = 53 mg/L for algae (Pseudokirchneriella subcapitata) (SIDS, 2005), it was classified in Category 3.
11 Hazardous to the aquatic environment (Long-term) Not classified
-
-
- - If chronic toxicity data are used, then it is classified as "Not classified" due to rapid degradability (a 19-day degradation rate: 77% (SIDS, 2005)), and 72-hour NOEC (r) = 4.5 mg/L for algae (Pseudokirchneriella subcapitata) (SIDS, 2005).
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to 48-hour EC50 > 350 mg/L for crustacea (Daphnia magna) (SIDS, 2005), rapid degradability (a 19-day degradation rate: 77% (SIDS, 2005)), and a low bioaccumulation estimate (Log Pow = -0.16 (SRC, 2013)).
From the above results, it was classified as "Not classified."
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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