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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	102-09-0
Chemical Name	Diphenyl carbonate
Substance ID	25A0004
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solid	Classification not possible	- -	-	-	No data available.
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	As LD50 value for rats, there are 1,500 mg/kg [OECD TG 401, GLP-compliant] (SIDS (2006)) and > 2,500 mg/kg (SIDS (2006)). It was classified in Category 4 based on the GLP-compliant data.
1	Acute toxicity (Dermal)	Not classified	- -	-	-	There are LD50 values for rats of > 500 mg/kg (SIDS (2006)) and > 2,000 mg/kg [OECD TG 402, GLP-compliant] (SIDS (2006)), and an LD50 value for rabbits of > 2,000 mg/kg [OECD TG 402, GLP-compliant] (SIDS (2006)). It was classified as "Not classified" based on the GLP-compliant data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Not classified	- -	-	-	It was classified as "Not classified" because there was no irritationin in the result of skin irritation test with rabbits according to OECD TG 404 (SIDS (2006)).
3	Serious eye damage/eye irritation	Not classified	- -	-	-	It was classified as "Not classified" because there was no irritation in the results from two tests including an eye irritation test with rabbits according to OECD TG 405 (SIDS (2006)).
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	It is reported that it was negative in a Buehler test with guinea pigs, but the number of animals was less than that written in the guideline (SIDS (2006)). Because other information could not be obtained, it was classified as "Classification not possible" due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative on the whole in two micronucleus tests with mouse bone marrow cells (negative and equivocal results), and negative in an unscheduled DNA synthesis test with rat hepatocytes (SIDS (2006)). As for in vitro, it was negative in a bacterial reverse mutation test and a gene mutation test with cultured mammalian cells, and positive in a chromosomal aberration test with cultured mammalian cells (SIDS (2006)).
6	Carcinogenicity	Classification not possible	- -	-	-	There are no classification results for carcinogenicity by international organizations. Two 18-month carcinogenicity tests with male and female mice conducted in 1967 are described in SIDS (2006). Male and female (C57BL/6 X C3H/Anf) F1 mice and (C57BL/6 X AKR) F1 mice were used, and only one dose of 100 mg/kg bw/day (260 ppm) was given by gavage for the first 3 weeks followed by feeding in the tests. Because they were not according to the current guideline, the purity of test substance and the test methods were inadequate, and the contents of reports were limited, it is written in SIDS (2006) that they are not reliable data. Therefore, it was classified as "Classification not possible" due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, reproductive toxicity was not observed in a one-generation test with rats. In a developmental toxicity test with rats, reduced body weights and an increase in unspecific skeletal malformations (mainly dysplastic forelimb bones) was observed in fetuses at the dose (750 mg/kg bw/day) where severe toxicity was found in maternal animals including death (5/26 animals), tremor, piloerection and a decrease in body weights. An increase in delayed ossification (mainly toes and cervical vertebral bodies) was observed in fetuses at the dose (200 mg/kg bw/day) where there was slight toxicity in maternal animals showing a transient decrease in food consumption and weight gain depression (SIDS (2006)). The effects found in the developmental toxicity test are thought to be secondary effects related to maternal toxicity, but they cannot be denied perfectly. Therefore, it was classified as "Classification not possible."
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	It was classified in Category 2 (nervous system) because clonic convulsions were observed within the guidance value range for Category 2 (1,500 mg/kg) in oral administration to mice (SIDS (2006)).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In oral administration to rats, effects on the adrenal gland, ovary, and liver were observed at the doses (200-219 mg/kg/day) above the guidance values for Category 2 (SIDS (2006)). Therefore, it corresponds to "Not classified" in the oral route. However, because there is no information on repeated exposure in the other routes, the classification is not possible due to lack of data.
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 1	Warning	H400	P273 P391 P501	From 72-hour ErC50 = 0.9 mg/L for algae (Desmodesmus subspicatus) (SIDS, 2006), it was classified in Category 1.
11	Hazardous to the aquatic environment (Long-term)	Category 2	-	H411	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 2 due to being not rapidly degradable (degradation of 37% in a degradation test using aerobic activated sludge after 28 days, SIDS, 2006), and 72-hour NOEC = 0.22 mg/L for algae (Desmodesmus subspicatus) (SIDS, 2006). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being not rapidly degradable (degradation of 37% in a degradation test using aerobic activated sludge after 28 day, SIDS, 2006), and 96-hour LC50 = 3.9 mg/L for fish (Danio rerio) (SIDS, 2006). From the above results, it was classified in Category 2.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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