NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	2768-02-7
Chemical Name	Vinyltrimethoxysilane
Substance ID	25A0003
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It was classified in Category 2 based on a flash point of 22 deg C (closed cup) (SIDS (2010)) and a boiling point of 123 deg C (SIDS (2010)).
7	Flammable solid	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	It does not contain a chemical group associated with explosive properties but contains a chemical group associated with self-reactive properties (unsaturated bond), but the classification is not possible due to no data.
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available.
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Classification not possible	- -	-	-	No data available. Besides, there is data on water solubility: 1,4400 mg/L (25 deg C) (estimated value) (SRC (2013)), but it was not adopted because it is an estimated value.
13	Oxidizing liquids	Classification not possible	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the element other than carbon or hydrogen (Si). However, the classification is not possible due to no data.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on LD50 values of 7,120 mg/kg (males), 7,236 mg/kg (females), 7,954 mg/kg (males and females) (all SIDS (2010)), and 300-2,000 mg/kg (females) (SIDS (2010), JECDB (Access on July 2013)) for rats, it was classified as "Not classified" to which most data correpond.
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" based on LD50 values for rabbits of about 3,880 mg/kg (males) and about 3,259 mg/kg (females) (SIDS (2010)).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Category 4	Warning	H332	P304+P340 P261 P271 P312	It was classified in Category 4 based on a 4-hour LC50 value of 2,773 ppmV (male and female) for rats (SIDS (2010)). Besides, because LC50 was lower than 90% of the saturated vapour pressure concentration (20,263 ppmV), a reference value in the unit of ppmV was applied as vapour with little mist.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.
3	Serious eye damage/eye irritation	Not classified	- -	-	-	It was classified as "Not classified" because it is described in SIDS (2010) that it was assessed to be not irritating in three tests in which this undiluted substance was applied to rabbits (OECD TG 405, etc.).
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, it is described in SIDS (2010) that there was skin sensitization in a Buehler test with guinea pigs (OECD TG 406) while it is also described that there was no skin sensitization in three maximization tests with guinea pigs (OECD TG 406). Therefore, it was classified as "Classification not possible."
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a micronucleus test with mouse peripheral blood erythrocytes (SIDS (2010)). As for in vitro, it was negative in both a bacterial reverse mutation test (JECDB (Access on July 2013), SIDS (2010)) and a gene mutation test (hgprt gene locus) with cultured mammalian cells (SIDS (2010)), and positive in a chromosomal aberration test with cultured mammalian cells (JECDB (Access on July 2013), SIDS (2010)). From the above data, it is concluded in SIDS (2010) that this substance is not genotoxic.
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, in JECDB (Access on July 2013), data from a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test were obtained, and only in the 1,000 mg/kg bw/day group, abnormalities in estrus cycles (lower number of estrous cases in 14 days before mating, 1,000 mg/kg bw/day group: 2.5 plus or minus 0.7, control group: 3.2 plus or minus 0.4) were observed, but there were no effects on copulation index and days needed for copulation, and no effects on fertility and offspring were seen. Furthermore, because 1,000 mg/kg bw/day was the dose where death in parent animals (2/12 animals in males, 1/12 animals in females) and lower body weights were observed, it was thought that the abnormalities in estrus cycles were slight changes related to general toxicity, not reproductive toxicity. However, the test is a screening test, and there was sufficient information on developmental toxicity, therefore it was classified as "Classification not possible.".
8	Specific target organ toxicity - Single exposure	Category 2 (central nervous system), Category 3 (narcotic effects)	Warning	H371 H336	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	Because in inhalation exposure in rats (vapour), hypoactivity, ataxia, prostration, tremors, and reflex disorders were observed at doses (11.9-32.5 mg/L) within the guidance value range (SIDS (2010)), it was classified in Category 2 (central nervous system). Furthermore, in oral administration to rats (970-31,040 mg/kg), reversible sluggishness, piloerection, unsteady gait, etc. were found (SIDS (2010)), and in dermal exposure in rabbits (1,940-7,760 mg/kg), reversible inanimation, unsteady gait, prostration were seen (SIDS (2010)). From the above results, it was classified in Category 3 (narcotic effects).
9	Specific target organ toxicity - Repeated exposure	Category 2 (urinary bladder)	Warning	H373	P260 P314 P501	It is described that in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats dosed orally, hyperplasia of the transitional epithelium in the urinary bladder was observed at the dose (62.5 mg/kg/day (converted guidance value: 29 mg/kg/day)) within a guidance value range for Category 2 (SIDS (2010), JECDB (Access on July 2013)). Therefore, it was classified in Category 2 (urinary bladder). Besides, in a test in which rats were exposed by inhalation to the vapour of this substance for 14 weeks, there were no findings to assign a category within a guidance value range, but effects on the kidney (papillary necrosis, interstitial edema, and papillary hyperplasia of the transitional epithelium) and urinary bladder (cystitis) were observed at the dose (2.4 mg/L/6 hours/day) corresponding to "Not classified" (SIDS (2010)).
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Not classified	- -	-	-	From 72-hour ErC50 > 89 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2004)), 96-hour LC50 > 92 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2004)), and 48-hour EC50 = 168.7 mg/L for crustacea (Daphnia magna) (SIDS, 2010), it was classified as "Not classified."
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	If chronic toxicity data are used, then it is classified as "Not classified" due to being not rapidly degradable (a 28-day degradation rate = 51% (SIDS, 2010)), and 72-hour NOEC (r) = 10 mg/L for algae (Desmodesmus subspicatus) (SIDS, 2010). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" because it corresponds to "Not classified" for fish in acute toxicity, and it is not water-insoluble (water solubility = 144000 mg/L, SRC, 2013). From the above results, it was classified as "Not classified."
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

To GHS Information