Item | Information |
---|---|
CAS RN | 688-84-6 |
Chemical Name | 2-Ethylhexyl methacrylate |
Substance ID | 24B6515 |
Classification year (FY) | FY2012 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2007 FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 4 |
Warning |
H227 |
P370+P378
P403+P235 P210 P280 P501 |
It corresponds to Category 4 from a flash point of 92 deg C [closed-cup] (MSDS (Sigma-Aldrich) (Access on Apr. 2012)) > 60 deg C and <= 93 deg C. |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | There is a chemical group associated with self-reactive properties (olefins) present in the molecule, but the classification is not possible due to no data. Besides, commercially available products have a purity of > 98% and contain hydroquinone monoalkyl (methyl or ethyl) ether as a stabilizer. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 380 deg C (GESTIS (Access on Apr. 2012)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | It was classified as "Not classified" because it is reported that there was no death after administering 2,000 mg/kg to rats (OECD TG401, GLP-compliant), and an LD50 value was 2,000 mg/kg or above (JECDB (Access on Apr. 2012)). |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | It was classified as "Not classified" based on the information of an LD50 value of > 17620 mg/kg for guinea pigs (SIDS (2004)). |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | There is the information of LC0 of > 14 ppm/6 hours for rats (converted 4-hour equivalent value: > 17 ppm) (SIDS (2004)), but because the category cannot be determined with the data alone, the classification is not possible. Besides, because the test concentration was lower than 90% of the saturated vapour pressure concentration (100 ppm), the reference value of gas was applied as a vapour with little mist. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 |
P302+P352
P332+P313 P362+P364 P264 P280 P321 |
It was classified in Category 2 because it was moderately irritating (PII = 3.12) or moderately irritating (PII = 4.04) in skin irritation tests with rabbits, although applied for 24 hours (SIDS (2004)). Besides, it was classified in R36/37/38 (irritating to the eye, respiratory system, and skin) in EU classification. |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | In two tests in which 0.1 mL of undiluted this substance was applied to the eyes of six rabbits, in one test, no exposure effects were observed in any animals, the primary irritation index was 0 (maximum 100), and it was judged non-irritating (SIDS (2004)). In the other test, it is described that slight conjunctival irritation found in 4/6 animals cleared by the end of the 72-hour observation period, and only one positive reaction was identified, but the test is considered to be negative overall (SIDS (2004)). Based on the above test results, it was classified as "Not classified." |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. |
4 | Skin sensitization | Category 1 |
Warning |
H317 |
P302+P352
P333+P313 P362+P364 P261 P272 P280 P321 P501 |
In maximization tests with guinea pigs, it was sensitizing with a positive rate of 30% (3/10) (SIDS (2004)), and it was negative (0/5) at a low concentration for induction but positive (4/10) at a high concentration (Initial Risk Assessment Report Ver.1.0, 23 (NITE, CERI, NEDO, 2008)). Therefore, it was classified in Category 1. Besides, it is reported that a positive rate was 0% (0/20) in another maximization test with guinea pigs (SIDS (2004)). |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, there is a report on negative results in a reverse mutation test, and a chromosomal aberration test with cultured Chinese hamster cells (JECDB (Access on Apr. 2012)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 |
P308+P313
P201 P202 P280 P405 P501 |
In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test by oral administration to rats (OECD TG422, GLP-compliant), decreases in the numbers of corpus luteum and implantation sites were observed as reproductive developmental toxicity in females at 1,000 mg/kg, and as for the development of offspring, decreased numbers of live pups on day 0 of lactation were found at or above 300 mg/kg. Furthermore, at the same doses, increased absolute and relative kidney weights were seen as general toxicity in parent animals (JECDB (Access on Apr. 2012)). Therefore, it was classified in Category 2. |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | As a result of single oral administration of 2,000 mg/kg to rats, there were no dead animals, and neither males nor females showed any general signs except for decreased body weights or any changes at necropsy (JECDB (Access on Apr. 2012)). Therefore, it is considered to correspond to "Not classified" in the oral route. However, because effects in the other routes (dermal, inhalation) are unknown due to no data, it was classified as "Classification not possible." |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test by oral administration to rats (OECD TG422, GLP-compliant), only increased relative liver weights and increased absolute and relative kidney weights in males and increased relative kidney weights in females were observed at 300 mg/kg/day (converted guidance value: about 150 mg/kg/day) exceeding the upper limit of the guidance value range, and no other effects were reported, including pathological changes (JECDB (Access on Apr. 2012)). Therefore, it corresponds to "Not classified" in the oral route. However, effects in the other routes are unknown due to no or insufficient data. Therefore, it was classified as "Classification not possible" for specific target organ toxicity (repeated exposure). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 |
- |
H401 |
P273
P501 |
It was classified in Category 2 from 96-hour LC50 = 2.78 mg/L for fish (Oryzias latipes) (Environmental Risk Assessment for Chemical Substances Vol. 3 (Ministry of the Environment, 2004)). |
11 | Hazardous to the aquatic environment (Long-term) | Category 2 |
- |
H411 |
P273
P391 P501 |
If chronic toxicity data are used, then it is classified in Category 3 due to being rapidly degradable (readily biodegradable (a 4-week degradation rate by BOD: 88%) (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1997)), and 21-day NOEC = 0.105 mg/L for crustacea (Daphnia magna) (SIDS, 2004). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to 96-hour LC50 = 2.78 mg/L for fish (Oryzias latipes) (Environmental Risk Assessment for Chemical Substances Vol. 3 (Ministry of the Environment, 2004)), and a high bioaccumulation estimate (log Kow = 4.54 (PHYSPROP Database, 2009)), although it is rapidly degradable (a 4-week degradation rate by BOD: 88% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1997)). By drawing a comparison between the above results, it was classified in Category 2. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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