NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	688-84-6
Chemical Name	2-Ethylhexyl methacrylate
Substance ID	24B6515
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2007 FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P403+P235 P210 P280 P501	It corresponds to Category 4 from a flash point of 92 deg C [closed-cup] (MSDS (Sigma-Aldrich) (Access on Apr. 2012)) > 60 deg C and <= 93 deg C.
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is a chemical group associated with self-reactive properties (olefins) present in the molecule, but the classification is not possible due to no data. Besides, commercially available products have a purity of > 98% and contain hydroquinone monoalkyl (methyl or ethyl) ether as a stabilizer.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 380 deg C (GESTIS (Access on Apr. 2012)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	It was classified as "Not classified" because it is reported that there was no death after administering 2,000 mg/kg to rats (OECD TG401, GLP-compliant), and an LD50 value was 2,000 mg/kg or above (JECDB (Access on Apr. 2012)).
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" based on the information of an LD50 value of > 17620 mg/kg for guinea pigs (SIDS (2004)).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	There is the information of LC0 of > 14 ppm/6 hours for rats (converted 4-hour equivalent value: > 17 ppm) (SIDS (2004)), but because the category cannot be determined with the data alone, the classification is not possible. Besides, because the test concentration was lower than 90% of the saturated vapour pressure concentration (100 ppm), the reference value of gas was applied as a vapour with little mist.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	It was classified in Category 2 because it was moderately irritating (PII = 3.12) or moderately irritating (PII = 4.04) in skin irritation tests with rabbits, although applied for 24 hours (SIDS (2004)). Besides, it was classified in R36/37/38 (irritating to the eye, respiratory system, and skin) in EU classification.
3	Serious eye damage/eye irritation	Not classified	- -	-	-	In two tests in which 0.1 mL of undiluted this substance was applied to the eyes of six rabbits, in one test, no exposure effects were observed in any animals, the primary irritation index was 0 (maximum 100), and it was judged non-irritating (SIDS (2004)). In the other test, it is described that slight conjunctival irritation found in 4/6 animals cleared by the end of the 72-hour observation period, and only one positive reaction was identified, but the test is considered to be negative overall (SIDS (2004)). Based on the above test results, it was classified as "Not classified."
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	In maximization tests with guinea pigs, it was sensitizing with a positive rate of 30% (3/10) (SIDS (2004)), and it was negative (0/5) at a low concentration for induction but positive (4/10) at a high concentration (Initial Risk Assessment Report Ver.1.0, 23 (NITE, CERI, NEDO, 2008)). Therefore, it was classified in Category 1. Besides, it is reported that a positive rate was 0% (0/20) in another maximization test with guinea pigs (SIDS (2004)).
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, there is a report on negative results in a reverse mutation test, and a chromosomal aberration test with cultured Chinese hamster cells (JECDB (Access on Apr. 2012)).
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test by oral administration to rats (OECD TG422, GLP-compliant), decreases in the numbers of corpus luteum and implantation sites were observed as reproductive developmental toxicity in females at 1,000 mg/kg, and as for the development of offspring, decreased numbers of live pups on day 0 of lactation were found at or above 300 mg/kg. Furthermore, at the same doses, increased absolute and relative kidney weights were seen as general toxicity in parent animals (JECDB (Access on Apr. 2012)). Therefore, it was classified in Category 2.
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	As a result of single oral administration of 2,000 mg/kg to rats, there were no dead animals, and neither males nor females showed any general signs except for decreased body weights or any changes at necropsy (JECDB (Access on Apr. 2012)). Therefore, it is considered to correspond to "Not classified" in the oral route. However, because effects in the other routes (dermal, inhalation) are unknown due to no data, it was classified as "Classification not possible."
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test by oral administration to rats (OECD TG422, GLP-compliant), only increased relative liver weights and increased absolute and relative kidney weights in males and increased relative kidney weights in females were observed at 300 mg/kg/day (converted guidance value: about 150 mg/kg/day) exceeding the upper limit of the guidance value range, and no other effects were reported, including pathological changes (JECDB (Access on Apr. 2012)). Therefore, it corresponds to "Not classified" in the oral route. However, effects in the other routes are unknown due to no or insufficient data. Therefore, it was classified as "Classification not possible" for specific target organ toxicity (repeated exposure).
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 2	- -	H401	P273 P501	It was classified in Category 2 from 96-hour LC50 = 2.78 mg/L for fish (Oryzias latipes) (Environmental Risk Assessment for Chemical Substances Vol. 3 (Ministry of the Environment, 2004)).
11	Hazardous to the aquatic environment (Long-term)	Category 2	-	H411	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 3 due to being rapidly degradable (readily biodegradable (a 4-week degradation rate by BOD: 88%) (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1997)), and 21-day NOEC = 0.105 mg/L for crustacea (Daphnia magna) (SIDS, 2004). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to 96-hour LC50 = 2.78 mg/L for fish (Oryzias latipes) (Environmental Risk Assessment for Chemical Substances Vol. 3 (Ministry of the Environment, 2004)), and a high bioaccumulation estimate (log Kow = 4.54 (PHYSPROP Database, 2009)), although it is rapidly degradable (a 4-week degradation rate by BOD: 88% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1997)). By drawing a comparison between the above results, it was classified in Category 2.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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