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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	108-60-1
Chemical Name	Dichloroisopropyl ether
Substance ID	24B6504
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P403+P235 P210 P280 P501	It corresponds to Category 4 from a flash point of 77 deg C [closed-cup] (GESTIS (Access on Jan. 2012)) > 60 deg C and <= 93 deg C.
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It was classified as "Not classified" because it is classified in Division 6.1 in UNRTDG (UN2490), not in Division 4.2.
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	There is the information that stainless steel and steel are durable as containers, and that it corrodes aluminum (Hommel (1996)). However, due to no test data on the corrosion rate, the classification is not possible.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	There are three LD50 values for rats [240 mg/kg (IARC 41 (1986)), 1,300 mg/kg (Environmental Risk Assessment for Chemical Substances vol. 6 (Ministry of the Environment, 2008)), 316-1,000 mg/kg (NTP TR 239 (1982))], one corresponds to Category 3, and two correspond to Category 4. It was classified in Category 4, to which more corresponded.
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" in the Classification JIS (corresponding to Category 5 in UN GHS classification) based on an LD50 value of 3,309 mg/kg for rabbits (IARC 41 (1986)).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	It was classified in Category 2 based on an LC50 value of 350 ppm by 8-hour exposure of rats (converted 4-hour equivalent value: 495 ppm) (HSDB (2003)). Besides, because LC50 was lower than 90% of the saturated vapour pressure concentration (1118 ppm), a reference value of gasses was applied.
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	It was classified as "Not classified" based on an LC50 value of 12.8 mg/L by 4-hour exposure of rats (HSDB (2003)). Besides, because LC50 was higher than the saturated vapour pressure concentration (7.96 mg/L), the reference value of a mist was applied.
2	Skin corrosion/irritation	Not classified	- -	-	-	There was little irritation after a non-occlusive application to the rabbit skin, and there was no response even after 20 applications on the auricle. However, moderate scaliness was produced after 20 applications to the abdomen by the poultice technique, and it is described that this substance is minimally irritating to the skin from the above data (PATTY (5th, 2001)). Therefore, it was classified as "Not classified."
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	It is described that this substance is minimally irritating to the rabbit eye (PATTY (5th, 2001)), but because data details are unknown, it was classified as "Classification not possible."
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	No data available.
5	Germ cell mutagenicity	Not classified	- -	-	-	It was classified as "Not classified" based on a negative result in a chromosomal aberration test with bone marrow after intraperitoneal administration to mice (in vivo somatic cell mutagenicity test) (NTP DB (Access on Jan. 2012)). Besides, both a sister chromatid exchange test with bone marrow after intraperitoneal administration to mice and a DNA synthesis test with mouse hepatocytes (in vivo somatic cell genotoxicity test) were reported to be negative (NTP DB (Access on Jan. 2012)). On the other hand, as for in vitro tests, it is reported that it was positive in all of an Ames test, a mouse lymphoma test, and a chromosomal aberration test with CHO cells (NTP DB (Access on Jan. 2012), IARC 41 (1986)).
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because IARC classified it in Group 3 for carcinogenicity (IARC 71 (1999)). Besides, in carcinogenicity tests by 2-year oral administration to rats and mice, in rats, the incidence of any tumors was not higher than in the control group, and carcinogenicity was not observed. However, in mice, it is reported that there were increased incidences of alveolar/bronchiolar adenoma in males and females and hepatocellular carcinoma in males, there was the occurrence of squamous cell papilloma or carcinoma in the stomach or forestomach, a rare tumor, in females, and carcinogenicity was found (NTP TR 239 (1982)).
7	Reproductive toxicity	Not classified	- -	-	-	It is reported that in a three-generation breeding test by feeding to rats, there were no reproductive or developmental effects (Environmental Risk Assessment for Chemical Substances vol. 6 (Ministry of the Environment, 2008)). And it is reported that in a developmental toxicity test with pregnant rats or rabbits orally dosed during the organogenesis period, reduced weight gain or a decrease in food consumption occurred in maternal animals in the high dose group, but no other effects were observed in maternal animals or fetuses in either animal species (Environmental Risk Assessment for Chemical Substances vol. 6 (Ministry of the Environment, 2008)). Because no adverse effects on sexual function and fertility or adverse effects on the development of fetuses were found in the three-generation breeding test and the developmental toxicity test, it was classified as "Not classified."
8	Specific target organ toxicity - Single exposure	Category 1 (liver), Category 3 (respiratory tract irritation)	Danger Warning	H370 H335	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	The lowest dose at which deaths were observed in rats after 8-hour inhalation exposure was 175 ppm (converted 4-hour equivalent value: 1.732 mg/L), and the hepatic and renal injury was also described (IARC 41 (1986)). In another test with rats, 6-hour inhalation exposure (converted 4-hour equivalent value: 6.0 mg/L) to 700 ppm caused deaths, and necropsy revealed slight lung irritation and moderate to severe hepatic damage, and after 6 to 8-hour exposure to 350 ppm (converted 4-hour equivalent value: 3.0-3.46 mg/L), lung congestion and liver necrosis were reported (PATTY (5th, 2001)). Because severe effects on the liver were commonly observed in the above two inhalation exposure tests, and the test concentrations corresponded to the guidance values for Category 1, it was classified in Category 1 (liver). And because slight lung irritation (lung congestion at the lethal dose) was reported, and irritation of the nose and lung was described as effects after inhalation exposure (IARC 41 (1986)), it was classified in Category 3 (respiratory tract irritation).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	It is reported that pneumonitis occurred at or above 50 mg/kg/day in a 13-week repeated oral administration test with mice (NTP TR 239 (1982)), however, there were no reports on lung changes in other mouse tests by 3-month or 2-year oral administration (Environmental Risk Assessment for Chemical Substances vol. 6 (Ministry of the Environment, 2008)). Therefore, the lung findings were considered inadequate for the rationale for classification, and it was classified as "Classification not possible." And in 3-month or 2-year oral administration tests with rats or mice, changes in hematological parameters, blood effects such as hemosiderin deposit and extramedullary hematopoiesis in the spleen, and hepatic effects such as elevated hepatic enzymes and hepatocellular necrosis were reported (Environmental Risk Assessment for Chemical Substances vol. 6 (Ministry of the Environment, 2008)), but these were not adopted because they were findings at the doses all exceeding the guidance value range.
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Classification not possible	- -	-	-	No data available.
11	Hazardous to the aquatic environment (Long-term)	Classification not possible	- -	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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