GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 52829-07-9
Chemical Name Bis(2,2,6,6-tetramethyl-4-piperidyl) sebacate
Substance ID 24A6145
Classification year (FY) FY2012
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Solid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Solid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Solid (GHS definition)
6 Flammable liquids Not applicable
-
-
- - Solid (GHS definition)
7 Flammable solids Classification not possible
-
-
- - No data available.
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- - Solid (GHS definition)
10 Pyrophoric solids Classification not possible
-
-
- - No data available.
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Solid (GHS definition)
14 Oxidizing solids Not applicable
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- - It was classified as "Not classified" in the Classification JIS (corresponding to Category 5 in UN GHS classification) based on an LD50 value of 3,700 mg/kg bw for rats (SIAP (2008)).
1 Acute toxicity (Dermal) Not classified
-
-
- - It was classified as "Not classified" in the Classification JIS (corresponding to Category 5 in UN GHS classification or "Not classified") based on an LD50 value of > 3,170 mg/kg bw for rats (SIAP (2008)).
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Category 2


Danger
H330 P304+P340
P403+P233
P260
P271
P284
P310
P320
P405
P501
It was classified in Category 2 based on a 4-hour exposure LC50 value of 0.5 mg/L for rats (SIAP (2008)). Besides, it was regarded as a test on dust because the LC50 value was higher than the saturated vapour pressure concentration (7.03E-09 mg/L).
2 Skin corrosion/irritation Not classified
-
-
- - It was classified as "Not classified" because there was minimal irritation in a test by a 24-hour application to the rabbit skin (SIAP (2008)).
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
It was classified in Category 1 because there was serious eye damage in a test by an application to the rabbit eye (SIAP (2008)).
4 Respiratory sensitization Classification not possible
-
-
- - No data available.
4 Skin sensitization Not classified
-
-
- - It was classified as "Not classified" because it was concluded that it was not considered to possess skin sensitization properties based on the available information from two guinea pig tests (a maximization test and a photosensitization test) (SIAP (2008)).
5 Germ cell mutagenicity Classification not possible
-
-
- - The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, it is reported that it was negative in both an Ames test and a chromosomal aberration test with human lymphocytes (OECD TG 473) (SIAP (2008)).
6 Carcinogenicity Classification not possible
-
-
- - No data available.
7 Reproductive toxicity Classification not possible
-
-
- - In a one-generation reproductive toxicity test by oral administration to rats (OECD TG 415), parent animals showed general toxicity such as decreased weight gain and food consumption in the high dose group (300 mg/kg/day), but there was no reproductive toxicity. And as for developmental toxicity, only slightly decreased pup weights during lactation were observed, and there were no other adverse effects (SIAP (2008)). However, due to no data on the investigation of fetuses at the end of gestation, data are insufficient on effects on the development of offspring. Therefore, it was classified as "Classification not possible."
8 Specific target organ toxicity - Single exposure Category 1 (systemic toxicity)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
It is reported that signs of dyspnea, trismus, tremor, and sedation were observed in a dose-dependent intensity in all treated animals in an acute toxicity test with rats by 4-hour inhalation exposure (LC50 value: 0.5 mg/L) (SIAP (2008)). The above signs and deaths occurred within the guidance values for Category 1, but because it was hard to specify the target organ, it was classified in Category 1 (systemic toxicity).
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - Findings reported in repeated dose toxicity tests with rats and dogs were limited to reduced weight gain and distentions of the small intestine in some animals on necropsy in a 28-day repeated oral administration toxicity test with rats (0, 50, 200, 600 mg/kg bw/day), reduced weight gain in a 90-day diet administration toxicity test with rats (males: 0, 26, 80 or 261 mg/kg bw/day, females: 0, 29, 90 or 277 mg/kg bw/day), and reduced weight gain and liver hypertrophy in a 28-day repeated oral administration toxicity test with dogs (males: 0, 27, 69 or 150 mg/kg bw/day, females: 0, 27, 78 or 155 mg/kg bw/day). Because no serious toxicity effects were observed, it was estimated to correspond to "Not classified" in the oral route. However, because effects are unknown in the other routes due to no data, it was classified as "Classification not possible" for this hazard class.
10 Aspiration hazard Classification not possible
-
-
- - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2
-
-
H401 P273
P501
It was classified in Category 2 from 72-hour ErC50 = 1.1 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)).
11 Hazardous to the aquatic environment (Long-term) Category 1


Warning
H410 P273
P391
P501
If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (a 28-day degradation rate by OECD Test Guideline 301B: 10-24% (SIAP (Conclusions Agreed in SIAM 26, 2008))), and 72-hour NOEC = 0.050 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)).
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being not rapidly degradable (a 28-day degradation rate by OECD Test Guideline 301B: 10-24% (SIAP (Conclusions Agreed in SIAM 26, 2008))), and 96-hour LC50 = 4.3 mg/L for fish (Lepomis macrochirus, Oncorhynchus mykiss) (SIAP (Conclusions Agreed in SIAM 26, 2008)).
By drawing a comparison between the above results, it was classified in Category 1.
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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