Item | Information |
---|---|
CAS RN | 13463-41-7 |
Chemical Name | Zinc salt of 2-pyridinethiol 1-oxide; Zinc pyrithione |
Substance ID | 24A6137 |
Classification year (FY) | FY2012 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Classification not possible |
- |
- | - | There is a chemical group associated with explosive properties (N-oxides) present in the molecule, but the classification is not possible due to no data. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | There is a chemical group associated with explosive properties (N-oxides) present in the molecule, but the classification is not possible due to no data. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | There is a metal (Zn) present in the molecule, but from data: water solubility of 123000 mg/L (25 deg C) (SRC PhysProp (Access on Oct. 2012)), it is estimated that it does not react vigorously with water. |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the elements other than carbon or hydrogen (N, Zn). However, the classification is not possible due to no data. |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 |
P301+P310
P264 P270 P321 P330 P405 P501 |
Both two LD50 values for rats of 177 mg/kg (PATTY (6th, 2012)) and 267 mg/kg (EPA RED (2004)) correspond to Category 3. |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | There are reports on an LD50 value for rats of > 2,000 mg/kg (EPA RED (2004)) and an LD50 value for rabbits of 2,270-8,000 mg/kg (PATTY (6th, 2012)), both of which correspond to "Not classified" in the Classification JIS (corresponding to Category 5 in UN GHS classification or "Not classified"). |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 2 |
Danger |
H330 |
P304+P340
P403+P233 P260 P271 P284 P310 P320 P405 P501 |
It was classified in Category 2 based on a 4-hour exposure LC50 value of 0.14 mg/L for rats (RTECS (2007): the original article, National Technical Information Service: OTS0527753-1). Besides, because the LC50 value was higher than the saturated vapour pressure concentration (3.2E-08 mg/L), it was regarded as an inhalation test on a mist. |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 |
P302+P352
P332+P313 P362+P364 P264 P280 P321 |
It was classified in Category 2 because it is reported that it was a moderate irritant in a skin irritation test with rabbits (PATTY (6th, 2012)). Besides, slight erythema and edema were reported in another test with rabbits (EPA RED (2004)). |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 |
P305+P351+P338
P337+P313 P264 P280 |
It was classified in Category 2A because severe conjunctival irritation and corneal opacity occurred in a test in which 10 mg of this substance was applied to the rabbit eye (PATTY (6th, 2012)). |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. |
4 | Skin sensitization | Category 1 |
Warning |
H317 |
P302+P352
P333+P313 P362+P364 P261 P272 P280 P321 P501 |
It was classified in Category 1 because it is listed as a contact allergen in Contact Dermatitis (5th, 2011). Besides, it is reported that there was no sensitization in a Buehler test with guinea pigs (EPA RED (2004)), but in humans, there are some case reports of persons who had a positive patch test to this substance after using a shampoo containing the substance, a person who developed allergic contact dermatitis after using such a shampoo, and others (PATTY (6th, 2012), HSDB (2011)). |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | It was classified as "Not classified" based on a negative result in a micronucleus test with bone marrow cells after intraperitoneal administration to mice (in vivo somatic cell mutagenicity test) (PATTY (6th, 2012)). Besides, as for in vitro tests, it is reported that it was negative in both an Ames test (NTP DB (1982)) and an HGPRT test with CHO cells (PATTY (6th, 2012)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Data are lacking. Besides, it is described that there were no histopathological findings, and no evidence of carcinogenicity was seen in a test by 2-year diet administration to rats at 10-50 ppm (PATTY (6th, 2012)), but the details are unknown. And USEPA classified sodium pyrithione in Group D (EPA RED (2004)). |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 |
P308+P313
P201 P202 P280 P405 P501 |
In a developmental toxicity test by oral administration to rats (doses: 0.75, 3, 15 mg/kg/day), increased salivation, reduced weight gain, and decreased food consumption were observed as apparent maternal toxicity, while a dose-dependent increase in postimplantation losses in response to an increase in early resorptions, a significant decrease in the number of live pups/litter, and a significant increase in the number of litter having offspring with malformations/variations in external, visceral, and skeletal systems (mainly digit abnormalities and dilatation of renal pelvis) were found (EPA RED (2004)). Furthermore, in a developmental toxicity test by oral administration to rabbits (doses: 0.5, 1.5, 3 mg/kg/day), no effects were seen on the incidence of external, visceral, and skeletal anomalies, but a dose-dependent increase in early resorptions, a dose-dependent increase in postimplantation losses corresponding to it, and a decrease in the number of live pups were observed similarly to rats (EPA RED (2004)). Therefore, it was classified in Category 2. Besides, no adverse effects were reported on sexual function and fertility in tests by oral or dermal administration to rats from before mating (Safety Test (Ministry of Economy, Trade and Industry, 2009), PATTY (6th, 2012)). |
8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system) |
Danger |
H370 |
P308+P311
P260 P264 P270 P321 P405 P501 |
There is a report on an LD50 value of 177 mg/kg and signs of hypoactivity, piloerection, muscular weakness, and diarrhea in an acute oral toxicity test with rats (PATTY (6th, 2012)). On the other hand, it is described that clear nervous disorders were observed after acute or subacute oral administration of this substance (EPA RED (2004)), and it is reported that cholinergic effects were found 30-60 minutes after intravenous administration (5 mg/kg) to pigs (EPA RED (2004)). In addition to these, the above signs after oral administration to rats were judged to be findings related to the nervous system. Therefore, it was classified in Category 1 (nervous system). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system, respiratory system) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
In a test by diet administration to rats at 250 ppm (12.5 mg/kg/day) for 9-14 days (converted guidance value: about 1.6 mg/kg/day), hindlimb muscle weakness, incoordination, and decreases in the amplitude of the evoked potential for sensory nerves and mixed sensory and motor nerves were observed (EPA RED (2004)). Furthermore, in a 14-day gavage administration test with rats, there were deaths at or above 30 mg/kg/day, and reduced weight gain and ataxic gait due to hindlimb paralysis were found at or above 3 mg/kg/day (converted guidance value: 0.465 mg/kg/day). Because the results show nervous symptoms at doses corresponding to the guidance value range for Category 1, it was classified in Category 1 (nervous system). And in a 90-day inhalation exposure test with rats (aerosols, 6 hours/day), deaths occurred at exposure concentrations of 0.0025 mg/L or above, and signs of rales, labored breathing, and gasping were seen. And lung weights increased, and related histopathological findings were mild subacute inflammation in the interstitial tissue in the lung and medial hypertrophy of the pulmonary arteries at a concentration of 0.01 mg/L corresponding to the guidance values for Category 1 (EPA RED (2004), HSDB (2011)). Therefore, it was classified in Category 1 (respiratory system). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 |
Warning |
H400 |
P273
P391 P501 |
It was classified in Category 1 from EC50 = 2.6 ppb for algae (Bacillariophyceae) (U.S. EPA: RED, 2004). |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 |
Warning |
H410 |
P273
P391 P501 |
It was classified in Category 1 due to being not rapidly degradable (not readily degradable, a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2003)), and NOEC = 1.22 ppb for fish (Pimephales promelas) (U.S. EPA: RED, 2004). |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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