Item | Information |
---|---|
CAS RN | 644-97-3 |
Chemical Name | Phenyldichlorophosphine |
Substance ID | 24A6118 |
Classification year (FY) | FY2012 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Not classified |
- |
- | - | A flash point of 113 deg C [closed-cup] (MSDS (Sigma-Aldrich) (2012)) is above 93 deg C. |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 159.4 deg C (319 deg F) (HSDB (2003)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - |
There is the information that it reacts vigorously with water and produces heat to emit toxic and corrosive hydrogen chloride or the vapour of hydrochloric acid (Hommel (1996)). However, because it does not emit flammable gases, it was classified as "Not classified." |
13 | Oxidizing liquids | Classification not possible |
- |
- | - | The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded to the element other than carbon or hydrogen (S). However, it was classified as "Classification not possible" due to no data. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | The classification is not possible due to no data in prescribed test methods. Besides, it is described that it corrodes metals, except 316 stainless steel, nickel, or Hastelloy (HSDB 2003), and "This substance is corrosive to most metals. Stainless steel (316), nickel, Hastelloy, glass, ceramic, and synthetic substances are resistant" (Hommel (1996)). |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
In an acute toxicity test with rats (OECD TG 420, GLP), there were no deaths after the administration of 500 mg/kg (0/10), an LD50 value was > 500 mg/kg, and one animal died (1/1) after the administration of 2,000 mg/kg in a preliminary dose-finding test previously conducted (USEPA/HPV (2004), corresponding to List 1). Therefore, it was classified in Category 4. Besides, this substance reacts vigorously with water and hydrolyzes. As for health hazards, also refer to hydrogen chloride (CAS: 7647-01-0) and phenylphosphine (CAS: 638-21-1), the degradation products. |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 |
P301+P330+P331
P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
It was classified in Category 1 because it is described that it is a high irritant to the skin, eye, and mucous membranes and is highly capable of causing deaths or permanent injury due to exposure of normal use in humans (HSDB (2003)), and it is also described that it is corrosive to the skin and tissue (HSDB (2003)). |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
It was classified in Category 1 because it is described that it is a high irritant to the skin, eye, and mucous membranes and is highly capable of causing deaths or permanent injury due to exposure of normal use in humans (HSDB (2003)), and it is also described that it is corrosive to the skin and tissue (HSDB (2003)). |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, there is a report on a positive result in an Ames test (USEPA/HPV (2004)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No data available. |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
It was classified in Category 3 (respiratory tract irritation) because it is described that breathing this substance can irritate the nose and throat and cause cough and shortness of breath, and high exposure can cause pneumonia and pulmonary edema (HSFS (2000)). Besides, it is reported that in an acute oral toxicity test with rats (OECD TG 420, GLP), no deaths or apparent toxic signs were observed after the administration of 500 mg/kg, and necropsy revealed mottled lung and froth in the trachea in two animals. And it is reported that in a preliminary test, one animal that died after the administration of 2,000 mg/kg showed black gastrointestinal contents, and gastrointestinal bleeding was suggested (USEPA/HPV (2004)). However, these were regarded as local effects because this substance is corrosive. |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | No data available. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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