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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	608-93-5
Chemical Name	1,2,3,4,5-Pentachlorobenzene
Substance ID	24A6115
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	- -	-	-	No data available.
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	- -	-	-	The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen.
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	It was classified in Category 4 based on LD50 values of 1,125 mg/kg (males) and 1,080 mg/kg (females) for rats (EHC 128 (1991)).
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" in the Classification JIS (Category 5 in UN GHS classification or "Not classified") based on an LD50 value of > 2,500 mg/kg for rats (EHC 128 (1991)).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	No data available.
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available.
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	No data available.
5	Germ cell mutagenicity	Not classified	- -	-	-	It was classified as "Not classified" from a negative result in a micronucleus test with peripheral blood after 90-day diet administration to mice (in vivo somatic cell mutagenicity test) (NTP DB (Access on Sep. 2012)). Besides, as for in vitro tests, it is reported that it was negative in an Ames test (NTP DB (1980)) and negative in a chromosomal aberration test with CHO cells (NTP DB (Access on Sep. 2012)).
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was classified in D in EPA (1986) (IRIS (2003)).
7	Reproductive toxicity	Category 2, Additional category: Effects on or via lactation	Warning	H361 H362	P308+P313 P201 P202 P280 P405 P501	In a developmental toxicity test by oral administration to pregnant rats during the organogenesis period, maternal animals did not show toxic signs, a trend toward a decrease in the number of live fetuses per litter and increased sternal defects were observed in the high dose group (200 mg/kg), and an increase in extra or fused ribs was reported in the treated groups (50-200 mg/kg) (PATTY (6th, 2012)). However, in another test with mice using the same treatment period and similar doses, increased liver weights were seen in maternal animals, but no adverse effects on the development of offspring were found (PATTY (6th, 2012)). From the above, because findings in rats did not constitute clear evidence to classify it in Category 1B, it was classified in Category 2. On the other hand, it was classified in the Additional category: Effects on or via lactation because tremors at or above 0.025% and increased preweaning mortality and reduced weight gain at 0.1% group were observed in the (preweaning) pups from maternal animals administered in the diet throughout a lactation period (Environmental Risk Assessment for Chemical Substances vol. 4 (Ministry of the Environment, 2005)).
8	Specific target organ toxicity - Single exposure	Category 2 (central nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	In acute toxicity tests with rats and mice (LD50 value: rats 1,080-1,125 mg/kg, mice 1,175-1,370 mg/kg), signs of decreased activity and tremors were observed at sublethal dose levels (corresponding to the guidance values for Category 2) in both animal species (EHC 128 (1991)), On the other hand, it is described that oral toxicity symptoms in rats and mice included tremors and central nervous system depression in reports on acute and subacute toxicity of pentachlorobenzene (HSDB (2010)), therefore it was classified in Category 2 (central nervous system).
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver, kidney, thyroid)	Warning	H373	P260 P314 P501	In a 13-week diet administration test with rats (doses: 0, 33, 100, 330, 1,000, or 2,000 ppm), hyaline droplet nephropathy specific to male rats including hyaline droplet accumulation in the tubular epithelium was observed in the kidney in treated males, and exacerbated spontaneous nephropathy characterized by renal tubular cell regeneration and intratubular protein casts was found in addition to pigmentation and mineralization in males at or above 330 ppm (16.5 mg/kg/day), corresponding to the guidance values for Category 2, and females at or above 1,000 ppm (50 mg/kg/day) (NTP TOX 6 (1991)). Therefore, it was classified in Category 2 (kidney). And increased sorbitol dehydrogenase concentrations indicative of slight liver damage as well as centrilobular hepatocellular hypertrophy and yellow-brown granules were seen in males at or above 330 ppm and females at or above 1,000 ppm, and in a 13-week diet administration test with mice using the same protocol, centrilobular hepatocellular hypertrophy with slight necrosis was observed. Therefore, it was classified in Category 2 (liver). Furthermore, it was classified in Category 2 (thyroid) because thyroid follicular cell hypertrophy and a significant decrease in thyroxin concentrations were found at 1,000 and 2,000 ppm (100 mg/kg/day) in the above test with rats. Besides, there are no case reports on occupational exposure or epidemiological surveys in humans (EHC 128 (1991)).
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 48-hour EC50 = 0.01 mg/L for for crustacea (Ceriodaphnia dubia) (CICAD 60, 2004).
11	Hazardous to the aquatic environment (Long-term)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (not readily degradable, a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1982)), and 28-day NOEC = 0.018 mg/L for fish (Cyprinodon variegatus) (CICAD 60, 2004). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being not rapidly degradable (not readily degradable, a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1982)), and 96-hour EC50 = 1.98 mg/L for algae (Skeletonema costatum) (EHC 128, 1991). By drawing a comparison between the above results, it was classified in Category 1.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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