Item | Information |
---|---|
CAS RN | 554-84-7 |
Chemical Name | m-Nitrophenol |
Substance ID | 24A6108 |
Classification year (FY) | FY2012 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not classified |
- |
- | - | There is a chemical group associated with explosive properties (N-O) present in the molecule, but because it is classified in Division 6.1, PG III in UNRTDG (UN1663), it is estimated that it does not correspond to the hazards of the highest precedence, explosives. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
7 | Flammable solids | Classification not possible |
- |
- | - | It is a combustible solid (Hommel (1996)), but the classification is not possible due to no prescribed test data. |
8 | Self-reactive substances and mixtures | Type G |
- |
- | - | There is a chemical group associated with explosive properties (N-O) present in the molecule, but because it is classified in Division 6.1, PG III in UNRTDG (UN1663), it was classified in Type G. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 400 deg C (Hommel (1996)). |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the element other than carbon or hydrogen (N). However, the classification is not possible due to no data on oxidization. |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
It was classified in Category 4 based on LD50 values of 930 mg/kg and 382 mg/kg for rats (HSDB (2003)). Besides, as for health hazards, also refer to the information on o-nitrophenol (CAS 88-75-5) and p-nitrophenol (CAS 100-02-7), the isomers. |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | It is described that this substance is a skin irritant (HSDB (2003)), and it is reported in List 3 information that there was moderate irritation after a 24-hour application of 20 mg to rabbits (RTECS (2006)), but the details are unknown. Therefore, it was classified as "Classification not possible." |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 |
P305+P351+P338
P337+P313 P264 P280 |
It is described that the solid or dust of this substance is irritating to the eyes (HSDB (2003)), and this substance is a severe eye irritant (HSDB (2003)), and although it is List 3 data, it is reported that there was severe irritation in a test in which 5 mg was applied to rabbits (RTECS (2006)). Therefore, it was classified in Category 2. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, contradicting results of being negative, positive, or weakly positive are reported in Ames tests (CICAD 20 (2000), NTP DB (Access on Sep. 2012)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No data available. |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | No data available. Besides, as data on the isomers, it is reported that in oral administration tests with cats, an increase in methemoglobin formation was observed for o-nitrophenol but not for p-nitrophenol (CICAD (J) 20 (2004)). |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | No data available. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 3 |
- |
H402 |
P273
P501 |
It was classified in Category 3 from for 96-hour LC50 = 17.5 mg/L fish (Cyprinus carpio) (CICAD 20, 2000). |
11 | Hazardous to the aquatic environment (Long-term) | Category 2 |
- |
H411 |
P273
P391 P501 |
If chronic toxicity data are used, then it is classified in Category 2 from 72-hour NOEC = 1.0 mg/L for algae (Chlorella pyrenoidosa) (AQUIRE, 2013), although it is not rapidly degradable (a degradation rate by BOD by a standard test method: 11, 80% (NO2) (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1980)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 due to being not rapidly degradable (a degradation rate by BOD by a standard test method: 11, 80% (NO2) (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1980)), and 96-hour LC50 = 17.5 mg/L for fish (Cyprinus carpio) (CICAD 20, 2000). By drawing a comparison between the above results, it was classified in Category 2. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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