GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 554-84-7
Chemical Name m-Nitrophenol
Substance ID 24A6108
Classification year (FY) FY2012
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not classified
-
-
- - There is a chemical group associated with explosive properties (N-O) present in the molecule, but because it is classified in Division 6.1, PG III in UNRTDG (UN1663), it is estimated that it does not correspond to the hazards of the highest precedence, explosives.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Solid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Solid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Solid (GHS definition)
6 Flammable liquids Not applicable
-
-
- - Solid (GHS definition)
7 Flammable solids Classification not possible
-
-
- - It is a combustible solid (Hommel (1996)), but the classification is not possible due to no prescribed test data.
8 Self-reactive substances and mixtures Type G
-
-
- - There is a chemical group associated with explosive properties (N-O) present in the molecule, but because it is classified in Division 6.1, PG III in UNRTDG (UN1663), it was classified in Type G.
9 Pyrophoric liquids Not applicable
-
-
- - Solid (GHS definition)
10 Pyrophoric solids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 400 deg C (Hommel (1996)).
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Solid (GHS definition)
14 Oxidizing solids Classification not possible
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the element other than carbon or hydrogen (N). However, the classification is not possible due to no data on oxidization.
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
It was classified in Category 4 based on LD50 values of 930 mg/kg and 382 mg/kg for rats (HSDB (2003)).

Besides, as for health hazards, also refer to the information on o-nitrophenol (CAS 88-75-5) and p-nitrophenol (CAS 100-02-7), the isomers.
1 Acute toxicity (Dermal) Classification not possible
-
-
- - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - No data available.
2 Skin corrosion/irritation Classification not possible
-
-
- - It is described that this substance is a skin irritant (HSDB (2003)), and it is reported in List 3 information that there was moderate irritation after a 24-hour application of 20 mg to rabbits (RTECS (2006)), but the details are unknown. Therefore, it was classified as "Classification not possible."
3 Serious eye damage/eye irritation Category 2


Warning
H319 P305+P351+P338
P337+P313
P264
P280
It is described that the solid or dust of this substance is irritating to the eyes (HSDB (2003)), and this substance is a severe eye irritant (HSDB (2003)), and although it is List 3 data, it is reported that there was severe irritation in a test in which 5 mg was applied to rabbits (RTECS (2006)). Therefore, it was classified in Category 2.
4 Respiratory sensitization Classification not possible
-
-
- - No data available.
4 Skin sensitization Classification not possible
-
-
- - No data available.
5 Germ cell mutagenicity Classification not possible
-
-
- - The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, contradicting results of being negative, positive, or weakly positive are reported in Ames tests (CICAD 20 (2000), NTP DB (Access on Sep. 2012)).
6 Carcinogenicity Classification not possible
-
-
- - No data available.
7 Reproductive toxicity Classification not possible
-
-
- - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - No data available. Besides, as data on the isomers, it is reported that in oral administration tests with cats, an increase in methemoglobin formation was observed for o-nitrophenol but not for p-nitrophenol (CICAD (J) 20 (2004)).
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - No data available.
10 Aspiration hazard Classification not possible
-
-
- - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3
-
-
H402 P273
P501
It was classified in Category 3 from for 96-hour LC50 = 17.5 mg/L fish (Cyprinus carpio) (CICAD 20, 2000).
11 Hazardous to the aquatic environment (Long-term) Category 2


-
H411 P273
P391
P501
If chronic toxicity data are used, then it is classified in Category 2 from 72-hour NOEC = 1.0 mg/L for algae (Chlorella pyrenoidosa) (AQUIRE, 2013), although it is not rapidly degradable (a degradation rate by BOD by a standard test method: 11, 80% (NO2) (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1980)).
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 due to being not rapidly degradable (a degradation rate by BOD by a standard test method: 11, 80% (NO2) (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1980)), and 96-hour LC50 = 17.5 mg/L for fish (Cyprinus carpio) (CICAD 20, 2000).
By drawing a comparison between the above results, it was classified in Category 2.
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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