Item | Information |
---|---|
CAS RN | 532-03-6 |
Chemical Name | 1-Carbamoyloxy-2-hydroxy-3-(2'-methoxyphenyloxy)propane |
Substance ID | 24A6107 |
Classification year (FY) | FY2012 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
14 | Oxidizing solids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
It was classified in Category 4 based on an LD50 value of 1,320 mg/kg for rats (RTECS (2007): the original article, Journal of Pharmacology and Experimental Therapeutics: 129, 75, 1960) after confirming the description in the original article. |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | No data available. |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | No data available. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. Besides, it is described as the information on humans that allergic reactions such as urticaria, pruritus, rash, skin eruptions, and conjunctivitis with nasal congestion may occur in patients receiving this substance (HSDB (2008)). |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | No data available. |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | There is a single case report in which arthrogryposis was found in a child from a pregnant woman treated with this substance (and other drugs) during embryogenesis (Birth Defects (2000), corresponding to List 2), and it is reported that one child with inguinal hernia was observed from 22 women treated with this substance by the 4th month of pregnancy (Teratogenic (2007), corresponding to List 2), but data are lacking to classify. |
8 | Specific target organ toxicity - Single exposure | Category 3 (Narcotic effects) |
Warning |
H336 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
This substance has been used as a medicine of a skeletal muscle relaxant (central nervous system depressant), and it is described that administration may cause decreases in attention, concentration, reflex motor ability, etc., and drowsiness (the package insert for Methocarbamol Granules). It is reported as the information on humans that one adult who ingested 22-30 g of this substance developed extreme drowsiness, but recovered by symptomatic treatment, and another adult survived after ingesting 30-50 g, and the principal symptom was drowsiness (HSDB (2008)). And it is described that administration to normal animals reduces spontaneous activity and decreases skeletal muscle tone, and large doses cause central nervous system depression and transient flaccid paralysis (HSDB (2008)). Therefore, it was classified in Category 3 (narcotic effects). |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Data are lacking. Besides, this substance has been used as a medicine of a skeletal muscle relaxant (central nervous system depressant), and it is described that administration may cause decreases in attention, concentration, reflex motor ability, etc., and drowsiness (the package insert for Methocarbamol Granules). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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