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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	121-92-6
Chemical Name	m-Nitrobenzoic acid
Substance ID	24A6095
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Classification not possible	- -	-	-	There is a chemical group associated with explosive properties (nitro group) present in the molecule, but the classification is not possible due to no data.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	- -	-	-	There is the information that it is combustible (HSDB (2008)), but the classification is not possible due to no data.
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is a chemical group associated with explosive properties (nitro group) present in the molecule, but the classification is not possible due to no data.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 490 deg C (GESTIS (Access on Aug. 2012)).
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Classification not possible	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the element other than carbon or hydrogen (N). However, the classification is not possible due to no data.
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	No data available. Besides, as for health hazards, also refer to the information on p-nitrobenzoic acid (CAS 62-23-7), the isomer of this substance.
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	No data available.
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available.
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	No data available.
5	Germ cell mutagenicity	Not classified	- -	-	-	It was classified as "Not classified" from a negative result in a micronucleus test with peripheral blood after 90-day diet administration to mice (in vivo somatic cell mutagenicity test) (NTP DB (Access on Aug. 2012)). Besides, as for in vitro tests, there were a positive result in an Ames test (NTP DB (1983)), a negative result in a chromosomal aberration test with CHO cells (NTP DB (Access on Aug. 2012)), and a positive result in a chromosomal aberration test with cells derived from Chinese hamster lung (CHL/IU cells) (OECD TG473, GLP) (JECDB (Access on Aug. 2012)).
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In a continuous breeding test by diet administration to mice, body weights of parent animals at the middle dose (0.75% in the diet) or the high dose (1.5% in the diet) were lower than those in the control group, while decreased litter size, a decreased number of deliveries at the middle and high doses and increased pup mortality before weaning at the high dose were observed (NTP Report RACB88105 (1990)). And in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test in which rats were orally administered for males for 42 days from 14 days before mating through mating, and for females through gestation and parturition until lactation day 4 (OECD TG422), at the high dose (500 mg/kg/day), there were pathological changes in the stomach and femur in parent animals, and especially in females, deaths and toxic signs occurred. On the other hand, there were decreases or tendencies toward decreases in developmental parameters such as delivery index, the number of corpus lutea, the number of implantations, the number of pups born, and the number of live pups on day 4 at the high dose (Safety Test (Ministry of Economy, Trade and Industry, 2007), corresponding to List 2). It was classified in Category 2 because adverse effects on the development of offspring were observed at the doses that caused general toxicity in parent animals in both the above two tests.
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	No data available.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test in which rats were administered by gavage for about 41-45 days from 14 days before mating till lactation day 4 (OECD TG422), at the high dose of 500 mg/kg/day (converted guidance value: about 240 mg/kg/day), three females died, and two of them showed drastic worsening such as decreased locomotor activity, irregular respiration, and prone position. On the other hand, squamous hyperplasia in the forestomach was observed at or above 100 mg/kg (converted guidance value: about 48 mg/kg/day), and the high dose group at 500 mg/kg/day showed changes in blood tests, erosion in the forestomach, focal inflammatory cellular infiltration in the forestomach, proliferation in the trabecular bone in the femur, degeneration of germinal epithelium in the testis, and a decrease in sperm and cell debris in the epididymal duct (Safety Test (Ministry of Economy, Trade and Industry, 2007)). The above effects were findings at the high dose above the guidance value range, except for lesions in the stomach, which were also seen at the middle dose corresponding to Category 2. It was not possible to deny the possibility of local effects due to oral administration, but the corrosivity/irritation of this substance is unknown, therefore it was classified as "Classification not possible."
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Classification not possible	- -	-	-	No data available.
11	Hazardous to the aquatic environment (Long-term)	Classification not possible	- -	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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