NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	121-03-9
Chemical Name	2-Methyl-5-nitrobenzenesulfonic acid
Substance ID	24A6094
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Classification not possible	- -	-	-	There is a chemical group associated with explosive properties (nitro group) present in the molecule, but the classification is not possible due to no data.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	- -	-	-	No data available.
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is a chemical group associated with explosive properties (nitro group) present in the molecule, but the classification is not possible due to no data.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of not below 500 deg C (IUCLID (2000)).
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Classification not possible	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the element other than hydrogen (N, S). However, the classification is not possible due to no data on oxidization.
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	In an acute toxicity test with rats, there were no dead animals in either males or females after administration of 500 mg/kg, one out of five animals died in both males and females after administration of 1,000 mg/kg, and all of five males and 4/5 females died after administration of 2,000 mg/kg (JECDB (Access on Aug. 2012)). Therefore, an LD50 value was estimated to be 1,000-2,000 mg/kg, and it was classified in Category 4.
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" based on an LD50 value of > 3,000 mg/kg for rats (IUCLID (2000)).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	It is reported that it was moderately irritating in a test in which 20 mg of this substance was applied to the rabbit skin for 24 hours (IUCLID (2000), RTECS (1997)), but it was classified in Category 1 from the knowledge that the pH of an aqueous solution (100 g/L) of this substance was less than 1 (IUCLID (2000)).
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	It was classified in Category 1 because it is reported that it was highly irritating in a test in which 20 mg of this substance was applied to the rabbit eye (IUCLID (2000), RTECS (1997)), and there is the knowledge that the pH of an aqueous solution (100 g/L) of this substance was less than 1 (IUCLID (2000)).
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, both positive (JECDB (Access on Aug. 2012)) and negative (IUCLID (2000)) results were obtained in Ames tests (OECD TG 471, 472, GLP), and there is a report on a negative result in a chromosomal aberration test with CHL cells (OECD TG 473, GLP) (JECDB (Access on Aug. 2012)).
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.
7	Reproductive toxicity	Classification not possible	- -	-	-	In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats (OECD TG 422; GLP), in the high dose group (700 mg/kg/day), parent animals showed toxic signs (such as wheezing, abdominal distention, emaciation, and decreased spontaneous movement), reduced weight gain, and decreased food consumption, and two females died or were killed in a moribund condition. At the dose, no effects of treatment of the test substance were observed in reproductive parameters such as estrous cycle, copulation index, fertility index, gestation length, gestation index, the number of corpus lutea, implantation index, delivery index, and as effects on pups, tendencies toward low body weights in males and females and toward low viability on day 4 were found, but there were no treatment-related effects on developmental parameters such as the number of live borns, the number of stillborn, live birth index, sex ratio, or no pups with external anomalies (JECDB (Access on Aug. 2012)). From the above results, no adverse effects were observed on sexual function and fertility, but as for effects on the development of offspring, there are no data on examination of fetuses before deliveries, therefore it was classified as "Classification not possible" due to lack of data.
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	No data available.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats (OECD TG 422; GLP), the groups at or above 350 mg/kg (converted guidance value: about 175 mg/kg/day) showed hyperplasia of mucosa at the limiting ridge and atrophy of mucosa in the cardiac region in the stomach, and the 700 mg/kg dose group (converted guidance value: about 350 mg/kg/day) showed erosion and superficial hemorrhage in the glandular stomach, wheezing, soft feces, abdominal distention, etc. And there were reduced weight gain, decreased food consumption, and changes in some blood or blood chemistry tests in males, one female died, and one female was killed in a moribund condition (JECDB (Access on Aug. 2012)). From the above, because the doses where effects were observed exceeded the upper limit of the guidance value range, and the stomach findings were judged as local effects of oral administration (because this substance is corrosive/irritating), they were not used for classification. Therefore, it is estimated to correspond to "Not classified" in oral administration. However, because of no information on the other routes, it was classified as "Classification not possible" for specific target organ toxicity (repeated exposure).
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Not classified	- -	-	-	It was classified as "Not classified" from 72-hour EC50 = 120 mg/L for algae (Pseudokirchneriella subcapitata), 48-hour EC50 = 130 mg/L for crustacea (Daphnia magna), and 96-hour LC50 > 100 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1997)).
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	If chronic toxicity data are used, then it is classified as "Not classified" due to being not rapidly degradable (not readily degradable, BOD 3% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2000)), and 21-day NOEC = 17 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1997)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" because it corresponds to "Not classified" for both crustacea and fish in acute toxicity, and it is not water-insoluble (water solubility = about 500 mg/L, NITE 2012). From the above results, it was classified as "Not classified."
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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