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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	110-64-5
Chemical Name	2-Butene-1,4-diol
Substance ID	24A6088
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Not classified	- -	-	-	A flash point of 127 deg C [closed-cup] (IUCLID (2000)) is above 93 deg C.
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Type G	- -	-	-	There is a chemical group associated with self-reactive properties (unsaturated bond) in the molecule. However, there is the information: "Instability: 0" (NFPA (14th, 2010)), and "the possibility of hazardous reactions: no special reactivity is reported" (MSDS (Tokyo Chemical Industry Co., Ltd.) (Access on Aug. 2012)). Therefore, it was judged not to be self-reactive, and it was classified in Type G.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 335 deg C (Ullmanns (E) (6th, 2003)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	It was classified in Category 4 based on an LD50 value of 856 mg/kg for rats (USEPA/HPV (2002), corresponding to List 1).
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	There is a report on an LD50 value of > 200 mg/kg for rabbits (USEPA/HPV (2002)), but the category cannot be determined. Therefore, the classification is not possible.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Because there were no deaths after 8-hour exposure to 7 ppm of the saturated vapour in rats (USEPA/HPV (2002)), LC0 was > 7 ppm/8 hours (0.025 mg/L/8 hours), and converted 4-hour equivalent value would be LC0 > 0.035 mg/L/4 hours, but the category cannot be determined. Therefore, the classification is not possible.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	It is reported that it was not irritating in a test with rabbits (IUCLID (2000)), but it is described that it is a primary irritant in humans (HSDB (2002)). Because the contents are contradicting, and the details are unknown, it was classified as "Classification not possible."
3	Serious eye damage/eye irritation	Not classified	- -	-	-	It was classified as "Not classified" because it was not irritating in a test with rabbits (IUCLID (2000)).
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	No data available.
5	Germ cell mutagenicity	Not classified	- -	-	-	It was classified as "Not classified" based on a negative result in a micronucleus test with bone marrow cells after oral administration to mice (in vivo somatic cell mutagenicity test) (USEPA/HPV (2002)). Besides, as for in vitro tests, there are reports on a negative result (USEPA/HPV (2002)) or positive result (NTP DB (2000)) in Ames tests.
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available. Besides, for maleic anhydride, which was estimated to be the primary metabolite of this substance, it is reported that there were no effects in a two-generation reproductive toxicity test and a developmental toxicity test by oral administration to rats (USEPA/HPV (2002)).
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Data are lacking. Besides, it is reported that there was suspicion of kidney toxicity at necropsy in an acute oral toxicity test with rats (LD50: 856 mg/kg) (USEPA/HPV (2002)), but there are no further descriptions, and the details are unknown. And it is reported that no effects were observed in a test by 8-hour inhalation exposure to 7 ppm (vapour) in rats or a test by dermal administration of 200 mg/kg to rabbits (USEPA/HPV (2002)), but both the doses were within the guidance value range, and effects at higher doses are unknown.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Data are lacking. Besides, there are data from a test by 13-day diet administration to two female rats/group and a test by 3-week oral administration to two rabbits/group, and it is described that there was no sufficient information to conclude repeated dose toxicity of this substance (USEPA/HPV (2002)).
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 3	- -	H402	P273 P501	It was classified in Category 3 from 48-hour EC50 = 65.2 mg/L for crustacea (Daphnia magna) (IUCLID, 2000).
11	Hazardous to the aquatic environment (Long-term)	Category 3	- -	H412	P273 P501	Reliable chronic toxicity data were not obtained. It was classified in Category 3 in acute toxicity because it is not rapidly degradable (readily biodegradable: BOD: 65, 55, 52% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2008)), and it was classified in Category 3 in acute toxicity.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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