Item | Information |
---|---|
CAS RN | 106-24-1 |
Chemical Name | Geraniol |
Substance ID | 24A6084 |
Classification year (FY) | FY2012 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule (it contains an unsaturated C-C bond, which is not 1,2-dienes). |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 4 |
Warning |
H227 |
P370+P378
P403+P235 P210 P280 P501 |
A test method is unknown for a flash point of 76 deg C [unknown] (Lange (2005)), but it is estimated to be > 60 deg C and <= 93 deg C in the prescribed test method. Therefore, it was classified in Category 4. |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Type G |
- |
- | - | There is a chemical group associated with self-reactive properties (olefins) in the molecule, but there is the information of "Instability: 0" in NFPA (14th, 2010). Therefore, it is estimated to be stable, and it was classified in Type G. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 250 deg C (GESTIS (Access on Aug. 2012)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | It was classified as "Not classified" in the Classification JIS (Category 5 in UN GHS classification) based on an LD50 value of 3,600 mg/kg bw for rats (JECFA 1095 (2004)). |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | It was classified as "Not classified" based on an LD50 value of > 5,000 mg/kg/bw for rabbits (IUCLID (2000)). |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. Besides, it is described in List 3 information that TCLo (Lowest Toxic Concentration) by 4-hour exposure was 0.5 mg/L for rats (RTECS (2011)). |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 |
P302+P352
P332+P313 P362+P364 P264 P280 P321 |
A test in which 0.5 mL of undiluted this substance was applied to rabbits (3 or 4 animals) for 4 hours (OECD TG 404, GLP) was conducted three times, slight to moderate erythema and slight to moderate edema were observed during an observation period (1-7 days), and the primary irritation index (PII) was 3.67, 3.33, 2.92, respectively (ECETOC TR 66 (1995)). Therefore, it was classified in Category 2. Besides, it is reported that this substance was severely irritating at a 32% concentration in a human patch test (HSDB (2007)). |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | No data available. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. |
4 | Skin sensitization | Category 1 |
Warning |
H317 |
P302+P352
P333+P313 P362+P364 P261 P272 P280 P321 P501 |
This substance was classified in Category 1 because it was listed as a contact allergen in Contact Dermatitis (5th, 2011). Besides, as human cases, it is reported that a 32-year-old woman who had worked for a company of baking ingredients, handling grated lemon peel and lemon oil for several years developed allergic contact dermatitis of the fingers of both her hands, and this substance was proven to be the only source of the allergic reaction as a result of investigation (HSDB (2007)), and it is reported that a bartender with dermatitis of hands developed allergic contact hypersensitivity of the skin against lemon, lime, and orange and was patch tested positive to this substance (HPVIS (2009)). On the other hand, as for animal tests, negative results are reported in a maximization test and a Buehler test with guinea pigs (IUCLID (2000)). |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, it was negative in an Ames test, but an equivocal result was obtained in a chromosomal aberration test with cultured Chinese hamster cells because polyploidization was observed (USEPA/HPV (2001)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No data available. |
8 | Specific target organ toxicity - Single exposure | Category 3 (Narcotic effects) |
Warning |
H336 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
It was classified in Category 3 (narcotic effects) because depression and coma were observed as toxic signs in an acute oral toxicity test with rats (LD50 value: 3600 mg/kg bw) (USEPA/HPV (2001)). |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | It is reported that no treatment-related effects were observed in any test item in a 16-week oral administration test with rats, and the NOEL was 10000 ppm (500 mg/kg bw/day) above the guidance value range (JECFA 1095 (2004)). Therefore, it is considered to correspond to "Not classified" in the oral route. However, because the test substance was a mixture with the isomer of an unknown ratio of this substance, and effects in the other routes (dermal, inhalation) are unknown due to no data, it was classified as "Classification not possible." |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 |
- |
H401 |
P273
P501 |
It was classified in Category 2 from 96-hour LC50 = 2.6 mg/L for fish (salmo trutta) (AQUIRE, 2013). |
11 | Hazardous to the aquatic environment (Long-term) | Not classified |
- |
- | - | Reliable chronic toxicity data were not obtained. It was classified in Category 2 in acute toxicity Category 2. However, it is rapidly degradable (readily biodegradable, BOD 36, 70% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1980)), and low bioaccumulation is estimated (LogKow = 3.47 (NITE, 2012)). Therefore, it was classified as "Not classified." |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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